Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Abnormal male germ cell morphology

MedGen UID:: 868309
•Concept ID:: C4022703
•: Anatomical Abnormality

HPO:	HP:0012863

Definition

A structural anomaly of a male reproductive cell. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal male germ cell morphology

Fetal anomaly
- Congenital Systemic Disorder
  - Abnormality of the genitourinary system
    - Abnormality of the genital system
      - Abnormal reproductive system morphology
        Abnormal germ cell morphology
        Abnormal male germ cell morphology
        Abnormal sperm morphology
        Abnormal sperm axoneme morphology
        Absent sperm axoneme central pair complex
        Abnormal sperm head morphology
        Acephalic spermatozoa
        Acrosomal hypoplasia
        Decreased acrosin in sperm head
        Enlarged sperm head vacuole
        Globozoospermia
        Macrozoospermia
        Microcephalic sperm head
        Pyriform sperm head
        Small acrosomal area
        Tapered sperm head
        Abnormal sperm mid-piece morphology
        Asymmetrical insertion of the midpiece into the head
        Thick spermatozoon midpiece insertion
        Thin spermatozoon midpiece
        Abnormal sperm neck morphology
        Bent sperm neck
        Abnormal sperm tail morphology
        Abnormal sperm principal piece morphology
        Absent sperm flagella
        Altered location of the longitudinal column in the fibrous sheath
        Bent sperm flagella
        Coiled sperm flagella
        Irregularly shaped sperm tail
        Multiflagellar spermatozoa
        Short sperm flagella
        Excess residual spermatozoal cytoplasm

Conditions with this feature

Spermatogenic failure 12

MedGen UID:: 815757
•Concept ID:: C3809427
•: Disease or Syndrome

Any azoospermia in which the cause of the disease is a mutation in the NANOS1 gene.

See: Condition Record

Spermatogenic failure 12

Professional guidelines

PubMed

Preimplantation diagnosis and other modern methods for prenatal diagnosis.

Simpson JL, Rechitsky S
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):124-130. Epub 2016 Apr 21 doi: 10.1016/j.jsbmb.2016.03.022. PMID: 27108943

Opinion: Comment on Evaluation and Treatment of Cryptorchidism: AUA/AAP and Nordic Consensus Guidelines.

Hadziselimovic F
Urol Int 2016;96(3):249-54. Epub 2016 Jan 30 doi: 10.1159/000443741. PMID: 26824668

Clinical genetic testing for male factor infertility: current applications and future directions.

Hotaling J, Carrell DT
Andrology 2014 May;2(3):339-50. Epub 2014 Apr 7 doi: 10.1111/j.2047-2927.2014.00200.x. PMID: 24711280

See all (134)

Recent clinical studies

Etiology

Thyroid dysfunction and semen quality.

La Vignera S, Vita R
Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418775241. doi: 10.1177/2058738418775241. PMID: 29737216 Free PMC Article

Reproductive genetics and the aging male.

Yatsenko AN, Turek PJ
J Assist Reprod Genet 2018 Jun;35(6):933-941. Epub 2018 Mar 9 doi: 10.1007/s10815-018-1148-y. PMID: 29524155 Free PMC Article

Epigenetic and risk factors of testicular germ cell tumors: a brief review.

Landero-Huerta DA, Vigueras-Villasenor RM, Yokoyama-Rebollar E, Arechaga-Ocampo E, Rojas-Castaneda JC, Jimenez-Trejo F, Chavez-Saldana M
Front Biosci (Landmark Ed) 2017 Mar 1;22(7):1073-1098. doi: 10.2741/4534. PMID: 28199193

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

Germ cell tumors.

Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272

See all (1769)

Diagnosis

The anatomy, movement, and functions of human sperm tail: an evolving mystery.

Kumar N, Singh AK
Biol Reprod 2021 Mar 11;104(3):508-520. doi: 10.1093/biolre/ioaa213. PMID: 33238303

Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells.

Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z
Nat Commun 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. PMID: 33173058 Free PMC Article

Advanced sperm testing.

Softness KA, Trussler JT, Carrasquillo RJ
Curr Opin Urol 2020 May;30(3):290-295. doi: 10.1097/MOU.0000000000000761. PMID: 32235275

Thyroid dysfunction and semen quality.

La Vignera S, Vita R
Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418775241. doi: 10.1177/2058738418775241. PMID: 29737216 Free PMC Article

Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017.

Gatimel N, Moreau J, Parinaud J, Léandri RD
Andrology 2017 Sep;5(5):845-862. Epub 2017 Jul 10 doi: 10.1111/andr.12389. PMID: 28692759

See all (1132)

Therapy

Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men.

Jannatifar R, Parivar K, Roodbari NH, Nasr-Esfahani MH
Reprod Biol Endocrinol 2019 Feb 16;17(1):24. doi: 10.1186/s12958-019-0468-9. PMID: 30771790 Free PMC Article

Pain Medications and Male Reproduction.

Drobnis EZ, Nangia AK
Adv Exp Med Biol 2017;1034:39-57. doi: 10.1007/978-3-319-69535-8_6. PMID: 29256126

The ICSI procedure from past to future: a systematic review of the more controversial aspects.

Rubino P, Viganò P, Luddi A, Piomboni P
Hum Reprod Update 2016 Mar-Apr;22(2):194-227. Epub 2015 Nov 18 doi: 10.1093/humupd/dmv050. PMID: 26586241

Androgen insensitivity syndrome.

Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA
Best Pract Res Clin Endocrinol Metab 2015 Aug;29(4):569-80. Epub 2015 Apr 26 doi: 10.1016/j.beem.2015.04.005. PMID: 26303084

Cryptorchidism --disease or symptom?

Toppari J, Rodprasert W, Virtanen HE
Ann Endocrinol (Paris) 2014 May;75(2):72-6. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.010. PMID: 24786701

See all (651)

Prognosis

Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects.

Dutta S, Sengupta P, Das S, Slama P, Roychoudhury S
Int J Mol Sci 2022 Sep 12;23(18) doi: 10.3390/ijms231810574. PMID: 36142487 Free PMC Article

Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.

Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q, O'Bryan MK, Cao Y, Tan YQ, Zhang F
Am J Hum Genet 2021 Feb 4;108(2):309-323. Epub 2021 Jan 19 doi: 10.1016/j.ajhg.2021.01.002. PMID: 33472045 Free PMC Article

Practical Molecular Testing in a Clinical Genitourinary Service.

Magers MJ, Cheng L
Arch Pathol Lab Med 2020 Mar;144(3):277-289. Epub 2019 Aug 2 doi: 10.5858/arpa.2019-0134-RA. PMID: 31373513

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

Maldescendus testis.

Toppari J, Kaleva M
Horm Res 1999 Dec;51(6):261-9. doi: 10.1159/000023412. PMID: 10640886

See all (708)

Clinical prediction guides

Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects.

Dutta S, Sengupta P, Das S, Slama P, Roychoudhury S
Int J Mol Sci 2022 Sep 12;23(18) doi: 10.3390/ijms231810574. PMID: 36142487 Free PMC Article

41,XX(Y) * male mice: An animal model for Klinefelter syndrome.

Wistuba J, Beumer C, Brehm R, Gromoll J
Am J Med Genet C Semin Med Genet 2020 Jun;184(2):267-278. Epub 2020 May 20 doi: 10.1002/ajmg.c.31796. PMID: 32432406

Germ cell loss in Klinefelter syndrome: When and why?

Willems M, Gies I, Van Saen D
Am J Med Genet C Semin Med Genet 2020 Jun;184(2):356-370. Epub 2020 May 15 doi: 10.1002/ajmg.c.31787. PMID: 32412180

Androgen insensitivity syndrome.

Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046

Germ cell tumors.

Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272

See all (1359)

Recent systematic reviews

Sperm DNA Fragmentation: Consequences for Reproduction.

Simon L, Emery B, Carrell DT
Adv Exp Med Biol 2019;1166:87-105. doi: 10.1007/978-3-030-21664-1_6. PMID: 31301048

Review: Diagnosis and impact of sperm DNA alterations in assisted reproduction.

Simon L, Emery BR, Carrell DT
Best Pract Res Clin Obstet Gynaecol 2017 Oct;44:38-56. Epub 2017 Aug 2 doi: 10.1016/j.bpobgyn.2017.07.003. PMID: 28935366

Effects of aging on the male reproductive system.

Gunes S, Hekim GN, Arslan MA, Asci R
J Assist Reprod Genet 2016 Apr;33(4):441-54. Epub 2016 Feb 11 doi: 10.1007/s10815-016-0663-y. PMID: 26867640 Free PMC Article

The ICSI procedure from past to future: a systematic review of the more controversial aspects.

Rubino P, Viganò P, Luddi A, Piomboni P
Hum Reprod Update 2016 Mar-Apr;22(2):194-227. Epub 2015 Nov 18 doi: 10.1093/humupd/dmv050. PMID: 26586241

Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis.

Campbell JM, Lane M, Owens JA, Bakos HW
Reprod Biomed Online 2015 Nov;31(5):593-604. Epub 2015 Aug 10 doi: 10.1016/j.rbmo.2015.07.012. PMID: 26380863

See all (26)

MedGen

National Center for Biotechnology Information

Send to:

Abnormal male germ cell morphology

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Recent activity