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Abnormal sperm morphology

MedGen UID:
588677
Concept ID:
C0403824
Disease or Syndrome; Finding
Synonym: Teratozoospermia
SNOMED CT: Teratozoospermia (236817003)
 
HPO: HP:0012864

Definition

A structural anomaly of sperm. [from HPO]

Conditions with this feature

Autosomal recessive nonsyndromic hearing loss 32
MedGen UID:
373370
Concept ID:
C1837608
Disease or Syndrome
DFNB32 is characterized by prelingual progressive moderate to profound sensorineural deafness. Some affected men are infertile, and semen analysis has shown high percentages of immotile sperm with abnormal morphology (Imtiaz et al., 2018).
Spermatogenic failure 10
MedGen UID:
766707
Concept ID:
C3553793
Disease or Syndrome
Spermatogenic failure-10 (SPGF10) is associated with a defective annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail. The firm attachment of the annulus to the flagellar membrane suggests that it may supply mechanical support and prevent displacement of the caudal mitochondrial helix (summary by Kuo et al., 2012). For a discussion of phenotypic and genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).
Spermatogenic failure 11
MedGen UID:
767367
Concept ID:
C3554453
Disease or Syndrome
Any azoospermia in which the cause of the disease is a mutation in the KLHL10 gene.
Spermatogenic failure 36
MedGen UID:
1678385
Concept ID:
C5193086
Disease or Syndrome
Spermatogenic failure-36 (SPGF36) is characterized by reduced fertility due to teratozoospermia, with spermatozoa showing anomalies of the head, acrosome, and nucleus (Guran et al., 2019). For a general description and a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).

Professional guidelines

PubMed

Check JH, Bollendorf A
Clin Exp Obstet Gynecol 2017;44(2):183-184. PMID: 29746017
Marchiani S, Vignozzi L, Filippi S, Gurrieri B, Comeglio P, Morelli A, Danza G, Bartolucci G, Maggi M, Baldi E
Mol Cell Endocrinol 2015 Feb 5;401:12-24. Epub 2014 Nov 11 doi: 10.1016/j.mce.2014.11.005. PMID: 25451982
Isidori A, Latini M, Romanelli F
Contraception 2005 Oct;72(4):314-8. doi: 10.1016/j.contraception.2005.05.007. PMID: 16181978

Recent clinical studies

Etiology

Sankhwar SN, Kumar P, Bagchi M, Rungta M, Bagchi D
J Am Nutr Assoc 2023 Jan;42(1):27-35. Epub 2021 Oct 25 doi: 10.1080/07315724.2021.1978348. PMID: 34694954
Sertorio MN, Estadella D, Ribeiro DA, Pisani LP
Crit Rev Food Sci Nutr 2023;63(14):2074-2081. Epub 2021 Aug 26 doi: 10.1080/10408398.2021.1970509. PMID: 34445915
Pérez-Soto E, Fernández-Martínez E, Oros-Pantoja R, Medel-Flores O, Miranda-Covarrubias JC, Sánchez-Monroy V
Medicina (Kaunas) 2021 Aug 24;57(9) doi: 10.3390/medicina57090862. PMID: 34577786Free PMC Article
Chabchoub I, Nouioui MA, Araoud M, Mabrouk M, Amira D, Ben Aribia MH, Mahmoud K, Zhioua F, Merdassi G, Hedhili A
Andrologia 2021 Oct;53(9):e14181. Epub 2021 Jul 4 doi: 10.1111/and.14181. PMID: 34219269
Ocek L, Tarhan H, Uludağ FI, Sarıteke A, Köse C, Colak A, Zorlu F, Zorlu Y
Acta Neurol Scand 2018 Apr;137(4):409-416. Epub 2018 Jan 7 doi: 10.1111/ane.12892. PMID: 29315457

Diagnosis

Liu M, Li J, Jiang C, Zhou Y, Sun Y, Yang Y, Shen Y
J Assist Reprod Genet 2022 Mar;39(3):757-764. Epub 2022 Feb 15 doi: 10.1007/s10815-022-02431-1. PMID: 35166991Free PMC Article
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ
Am J Hum Genet 2022 Jan 6;109(1):157-171. Epub 2021 Dec 20 doi: 10.1016/j.ajhg.2021.11.022. PMID: 34932939Free PMC Article
Pleuger C, Lehti MS, Dunleavy JE, Fietz D, O'Bryan MK
Hum Reprod Update 2020 Jun 18;26(4):474-500. doi: 10.1093/humupd/dmaa004. PMID: 32318721
Liu Y, Ding Z
Reproduction 2017 Oct;154(4):R123-R131. Epub 2017 Jul 26 doi: 10.1530/REP-17-0161. PMID: 28747541
Menkveld R, Holleboom CA, Rhemrev JP
Asian J Androl 2011 Jan;13(1):59-68. Epub 2010 Nov 15 doi: 10.1038/aja.2010.67. PMID: 21076438Free PMC Article

Therapy

Sankhwar SN, Kumar P, Bagchi M, Rungta M, Bagchi D
J Am Nutr Assoc 2023 Jan;42(1):27-35. Epub 2021 Oct 25 doi: 10.1080/07315724.2021.1978348. PMID: 34694954
Adamczak R, Ukleja-Sokołowska N, Pasińska M, Zielińska J, Leśny M, Dubiel M
Int J Immunopathol Pharmacol 2022 Jan-Dec;36:20587384211066718. doi: 10.1177/20587384211066718. PMID: 34984934Free PMC Article
Navaneethabalakrishnan S, Goodlett BL, Lopez AH, Rutkowski JM, Mitchell BM
Clin Sci (Lond) 2020 Dec 23;134(24):3237-3257. doi: 10.1042/CS20201023. PMID: 33346358Free PMC Article
Smarr MM, Kannan K, Chen Z, Kim S, Buck Louis GM
Andrology 2017 Nov;5(6):1082-1088. Epub 2017 Aug 29 doi: 10.1111/andr.12413. PMID: 28853221Free PMC Article
Isidori A, Latini M, Romanelli F
Contraception 2005 Oct;72(4):314-8. doi: 10.1016/j.contraception.2005.05.007. PMID: 16181978

Prognosis

Liu M, Li J, Jiang C, Zhou Y, Sun Y, Yang Y, Shen Y
J Assist Reprod Genet 2022 Mar;39(3):757-764. Epub 2022 Feb 15 doi: 10.1007/s10815-022-02431-1. PMID: 35166991Free PMC Article
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ
Am J Hum Genet 2022 Jan 6;109(1):157-171. Epub 2021 Dec 20 doi: 10.1016/j.ajhg.2021.11.022. PMID: 34932939Free PMC Article
Zhou QZ, Guo XB, Zhang WS, Zhou JH, Yang C, Bian J, Chen MK, Guo WB, Wang P, Qi T, Wang CY, Yang JK, Liu CD
Andrology 2019 Mar;7(2):220-227. Epub 2018 Dec 21 doi: 10.1111/andr.12573. PMID: 30575326Free PMC Article
Shabtaie SA, Gerkowicz SA, Kohn TP, Ramasamy R
Curr Urol Rep 2016 Sep;17(9):67. doi: 10.1007/s11934-016-0623-1. PMID: 27469478
Eisenberg ML, Li S, Behr B, Cullen MR, Galusha D, Lamb DJ, Lipshultz LI
Hum Reprod 2014 Jul;29(7):1567-74. Epub 2014 May 15 doi: 10.1093/humrep/deu106. PMID: 24838701Free PMC Article

Clinical prediction guides

Sankhwar SN, Kumar P, Bagchi M, Rungta M, Bagchi D
J Am Nutr Assoc 2023 Jan;42(1):27-35. Epub 2021 Oct 25 doi: 10.1080/07315724.2021.1978348. PMID: 34694954
Schlegel PN
Front Endocrinol (Lausanne) 2022;13:889959. Epub 2022 May 18 doi: 10.3389/fendo.2022.889959. PMID: 35663331Free PMC Article
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ
Am J Hum Genet 2022 Jan 6;109(1):157-171. Epub 2021 Dec 20 doi: 10.1016/j.ajhg.2021.11.022. PMID: 34932939Free PMC Article
Ocek L, Tarhan H, Uludağ FI, Sarıteke A, Köse C, Colak A, Zorlu F, Zorlu Y
Acta Neurol Scand 2018 Apr;137(4):409-416. Epub 2018 Jan 7 doi: 10.1111/ane.12892. PMID: 29315457
Shabtaie SA, Gerkowicz SA, Kohn TP, Ramasamy R
Curr Urol Rep 2016 Sep;17(9):67. doi: 10.1007/s11934-016-0623-1. PMID: 27469478

Recent systematic reviews

Henriques MC, Loureiro S, Fardilha M, Herdeiro MT
Reprod Toxicol 2019 Apr;85:93-103. Epub 2019 Mar 1 doi: 10.1016/j.reprotox.2019.02.012. PMID: 30831212
Kohn TP, Kohn JR, Ramasamy R
J Urol 2018 Mar;199(3):812-822. Epub 2017 Nov 9 doi: 10.1016/j.juro.2017.11.045. PMID: 29129781

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