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Abnormal cellular immune system morphology

MedGen UID:
869190
•Concept ID:
C4023612
•
Pathologic Function
Synonym: Abnormality of cellular immune system
 
HPO: HP:0010987

Definition

An abnormality of the morphology or counts of the cells that make up the immune system. [from HPO]

Professional guidelines

PubMed

Differential diagnosis of IgG4-positive plasma cells in the lung.
Mukhopadhyay S
Semin Diagn Pathol 2024 Mar;41(2):72-78. Epub 2023 Nov 15 doi: 10.1053/j.semdp.2023.11.006. PMID: 37993385
Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Hemolytic Anemia: Evaluation and Differential Diagnosis.
Phillips J, Henderson AC
Am Fam Physician 2018 Sep 15;98(6):354-361. PMID: 30215915

Recent clinical studies

Etiology

Adenoid lymphocyte heterogeneity in pediatric adenoid hypertrophy and obstructive sleep apnea.
Zhu Y, Wang S, Yang Y, Shen B, Wang A, Zhang X, Zhang X, Li N, Gao Z, Liu Y, Zhu J, Wei Z, Guan J, Su K, Liu F, Gu M, Yin S
Front Immunol 2023;14:1186258. Epub 2023 May 22 doi: 10.3389/fimmu.2023.1186258. PMID: 37283767Free PMC Article
SARS-COV-2 infection and lung tumor microenvironment.
Malkani N, Rashid MU
Mol Biol Rep 2021 Feb;48(2):1925-1934. Epub 2021 Jan 23 doi: 10.1007/s11033-021-06149-8. PMID: 33486674Free PMC Article
Histopathology of laryngomalacia.
Gan RWC, Moustafa A, Turner K, Knight L
Acta Otolaryngol 2021 Jan;141(1):85-88. Epub 2020 Oct 14 doi: 10.1080/00016489.2020.1821246. PMID: 33393421
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
Impact of prenatal immune system disturbances on brain development.
Madhusudan A, Vogel P, Knuesel I
J Neuroimmune Pharmacol 2013 Mar;8(1):79-86. Epub 2012 May 13 doi: 10.1007/s11481-012-9374-z. PMID: 22580757

Diagnosis

Congenital Vascular and Lymphatic Diseases.
Jung R, Trivedi CM
Circ Res 2024 Jun 21;135(1):159-173. Epub 2024 Jun 20 doi: 10.1161/CIRCRESAHA.124.323181. PMID: 38900856Free PMC Article
Approach to primary immunodeficiency.
Devonshire AL, Makhija M
Allergy Asthma Proc 2019 Nov 1;40(6):465-469. doi: 10.2500/aap.2019.40.4273. PMID: 31690396Free PMC Article
POEMS Syndrome: Diagnosis and Investigative Work-up.
Dispenzieri A, Kourelis T, Buadi F
Hematol Oncol Clin North Am 2018 Feb;32(1):119-139. doi: 10.1016/j.hoc.2017.09.010. PMID: 29157614
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
The thymus gland.
Askin DF, Young S
Neonatal Netw 2001 Dec;20(8):7-13. doi: 10.1891/0730-0832.20.8.7. PMID: 12144107

Therapy

Research progress on the role of macrophages in acne and regulation by natural plant products.
Zhao D, Wang Y, Wu S, Ji X, Gong K, Zheng H, Zhu M
Front Immunol 2024;15:1383263. Epub 2024 Apr 26 doi: 10.3389/fimmu.2024.1383263. PMID: 38736879Free PMC Article
Immunomodulatory Effects of Tryptophan Metabolism in the Glioma Tumor Microenvironment.
Xu Y, Zhang H, Sun Q, Geng R, Yuan F, Liu B, Chen Q
Front Immunol 2021;12:730289. Epub 2021 Oct 1 doi: 10.3389/fimmu.2021.730289. PMID: 34659216Free PMC Article
NK cell-based cancer immunotherapy: from basic biology to clinical development.
Liu S, Galat V, Galat Y, Lee YKA, Wainwright D, Wu J
J Hematol Oncol 2021 Jan 6;14(1):7. doi: 10.1186/s13045-020-01014-w. PMID: 33407739Free PMC Article
Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.
Wang J, Xu Y, Chen Z, Liang J, Lin Z, Liang H, Xu Y, Wu Q, Guo X, Nie J, Lu B, Huang B, Xian H, Wang X, Wu Q, Zeng J, Chai C, Zhang M, Lin Y, Zhang L, Zhao S, Tong Y, Zeng L, Gu X, Chen ZG, Yi S, Zhang T, Delfouneso D, Zhang Y, Nutt SL, Lew AM, Lu L, Bai F, Xia H, Wen Z, Zhang Y
Cell 2020 Dec 23;183(7):1867-1883.e26. Epub 2020 Nov 27 doi: 10.1016/j.cell.2020.10.048. PMID: 33248023
POEMS Syndrome: Diagnosis and Investigative Work-up.
Dispenzieri A, Kourelis T, Buadi F
Hematol Oncol Clin North Am 2018 Feb;32(1):119-139. doi: 10.1016/j.hoc.2017.09.010. PMID: 29157614

Prognosis

A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.
Wagner J, Rapsomaniki MA, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, Rees M, Ramaswamy A, Muenst S, Soysal SD, Jacobs A, Windhager J, Silina K, van den Broek M, Dedes KJ, Rodríguez Martínez M, Weber WP, Bodenmiller B
Cell 2019 May 16;177(5):1330-1345.e18. Epub 2019 Apr 11 doi: 10.1016/j.cell.2019.03.005. PMID: 30982598Free PMC Article
The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy.
Heymans S, Eriksson U, Lehtonen J, Cooper LT Jr
J Am Coll Cardiol 2016 Nov 29;68(21):2348-2364. doi: 10.1016/j.jacc.2016.09.937. PMID: 27884253
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Peripheral T cell lymphoma in Asia.
Park S, Ko YH
Int J Hematol 2014 Mar;99(3):227-39. Epub 2014 Jan 31 doi: 10.1007/s12185-014-1520-3. PMID: 24481942
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Clinical prediction guides

DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity.
Boussard C, Delage L, Gajardo T, Kauskot A, Batignes M, Goudin N, Stolzenberg MC, Brunaud C, Panikulam P, Riller Q, Moya-Nilges M, Solarz J, Repérant C, Durel B, Bordet JC, Pellé O, Lebreton C, Magérus A, Pirabakaran V, Vargas P, Dupichaud S, Jeanpierre M, Vinit A, Zarhrate M, Masson C, Aladjidi N, Arkwright PD, Bader-Meunier B, Baron Joly S, Benadiba J, Bernard E, Berrebi D, Bodemer C, Castelle M, Charbit-Henrion F, Chbihi M, Debray A, Drabent P, Fraitag S, Hié M, Landman-Parker J, Lhermitte L, Moshous D, Rohrlich P, Ruemmele F, Welfringer-Morin A, Tusseau M, Belot A, Cerf-Bensussan N, Roelens M, Picard C, Neven B, Fischer A, Callebaut I, Ménager M, Sepulveda FE, Adam F, Rieux-Laucat F
Blood 2023 Jun 1;141(22):2713-2726. doi: 10.1182/blood.2022018486. PMID: 36952639
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
Autoantibodies in autism spectrum disorders (ASD).
Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J
Ann N Y Acad Sci 2007 Jun;1107:79-91. doi: 10.1196/annals.1381.009. PMID: 17804535
B cell abnormality and autoimmune disorders.
Tsubata T
Autoimmunity 2005 Aug;38(5):331-7. doi: 10.1080/08916930500123959. PMID: 16240466
Hematological complications of alcoholism.
Ballard HS
Alcohol Clin Exp Res 1989 Oct;13(5):706-20. doi: 10.1111/j.1530-0277.1989.tb00408.x. PMID: 2688472

Recent systematic reviews

Single cell analysis in systemic sclerosis - A systematic review.
Fukasawa T, Yoshizaki-Ogawa A, Enomoto A, Yamashita T, Miyagawa K, Sato S, Yoshizaki A
Immunol Med 2024 Sep;47(3):118-129. Epub 2024 May 31 doi: 10.1080/25785826.2024.2360690. PMID: 38818750
Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells-Peritoneal Stroma Interactions.
Terri M, Trionfetti F, Montaldo C, Cordani M, Tripodi M, Lopez-Cabrera M, Strippoli R
Front Immunol 2021;12:607204. Epub 2021 Mar 29 doi: 10.3389/fimmu.2021.607204. PMID: 33854496Free PMC Article
Cellular models to study bipolar disorder: A systematic review.
Viswanath B, Jose SP, Squassina A, Thirthalli J, Purushottam M, Mukherjee O, Vladimirov V, Patrinos GP, Del Zompo M, Jain S
J Affect Disord 2015 Sep 15;184:36-50. Epub 2015 May 28 doi: 10.1016/j.jad.2015.05.037. PMID: 26070045
Systemic mastocytosis--a systematic review.
Andersen CL, Kristensen TK, Severinsen MT, Møller MB, Vestergaard H, Bergmann OJ, Hasselbalch HC, Bjerrum OW
Dan Med J 2012 Mar;59(3):A4397. PMID: 22381091
Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review.
Ford AC, Talley NJ
J Gastroenterol 2011 Apr;46(4):421-31. Epub 2011 Feb 18 doi: 10.1007/s00535-011-0379-9. PMID: 21331765

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