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Glioma
The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes). [from HPO]
Glioblastoma
Glioblastomas are malignant astrocytic tumors (grade IV according to the WHO classification). [from ORDO]
Glioblastoma multiforme
A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation. [from HPO]
Neoplasm of brain
A benign or malignant neoplasm that arises from or metastasizes to the brain. [from HPO]
Oligoastrocytoma
Oligoastrocytoma is a type of low-grade glioma with a mixed astrocytoma and oligodendroglioma histology, manifesting with headaches, speech and motor problems, seizures and, in some, subarachnoid haemorrhage. [from ORDO]
Neoplasm of the central nervous system
A neoplasm of the central nervous system. [from HPO]
Protoplasmic astrocytoma
A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (Adapted from WHO) [from NCI]
Neoplasm of the nervous system
A tumor (abnormal growth of tissue) of the nervous system. [from HPO]
Aging
Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]
Astrocytoma
Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma. [from HPO]
Childhood astrocytic tumor
An astrocytic tumor appearing before the age of twenty one without designation of benign or malignant nor designated location. [from NCI]
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