GEO DataSets

(Submitter supplied) Determine the transcriptomic response of Aspergillus fumigatus strains to different alleles of atrR

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25907

8 Samples

Download data: TXT, WIG

(Submitter supplied) To determine the genomic binding sites for the Aspergillus fumigatus transcription factor AtrR, we utilized three different strains. One was the wild-type AfS35 which contains a wild-type copy of atrR but lacks any HA tag. The other two are both derived from AfS35 but contain a 3X HA tag replacing the stop codon of atrR. These strains are SPF89 and SPF112, respectively. SPF89 uses the wild-type atrR promoter to drive expression of the epitope-tagged allele while SPF112 uses the much strong hspA promoter to drive production of the same protein.

Organism:

Aspergillus fumigatus Af293

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL25869

6 Samples

Download data: WIG

(Submitter supplied) Corticosteroid use has epidemiologically been associated with invasive aspergillosis. We found that hydrocortisone and MP in physiological concentrations cause a change in morphology of A. fumigatus 293 growth with a less dense core, and straighter outgrowth of longer hyphae. Treated with MP, we found a differential expression of genes annotated to cell wall structure, and to cell cycle programme compared to untreated control, which could explain the changes in morphology. more...

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17108

6 Samples

Download data: TXT