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Items: 17

1.

Gene expression profile of syphilis complicated with diabetes

(Submitter supplied) To further investigate the pathogenesis of syphilis with diabetes, we used a gene chip expression profile from a rabbit model of syphilis with diabetes as a discovery platform to identify potential genes. Grouped into normal control group (n=2) and syphilis combined with diabetes group (n=3).
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
6 Samples
Download data: TXT
Series
Accession:
GSE135053
ID:
200135053
2.

Development of gene expression signatures for progression and regression of atherosclerosis

(Submitter supplied) To further study the important genes related with the diagnosis and prognosis of atherosclerosis, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the atherosclerosis. we established a rabbit model of progression and regression of atherosclerosis through balloon injury and high-cholesterol diet and normal diet. Rabbit abdominal aortas from atherosclerosis among control, model group (progression) and recovery groups (regression) were collected. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
3 Samples
Download data: TXT
Series
Accession:
GSE122669
ID:
200122669
3.

Gene expression profiling of vein graft restenosis

(Submitter supplied) Occlusive artery disease (CAD) is the leading cause of death worldwide. Bypass graft surgery remains the prevalently performed treatments for occlusive arterial disease, and veins are the most frequently used conduits for surgical revascularization. However, clinical efficacy is highly affected by the long-term potency rates of vein grafts, and no optimal treatments are available for prevention of vein graft restenosis (VGR) until today. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
16 Samples
Download data: TXT
Series
Accession:
GSE110398
ID:
200110398
4.

Gene expression analysis of pulmonary artery in a rabbit model of pulmonary thromboembolism

(Submitter supplied) Acute pulmonary thromboembolism (PTE) refers to the obstruction of the pulmonary artery or its branches by thrombus. Recent studies suggest that PTE-induced endothelium injury is the major physiological consequence of PTE, and PTE-induced endothelium injury can be used to stratify disease severity. Several plasma biomarkers have been identified in PTE patients, but genome-wide gene expression has not been attempted in PTE. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
8 Samples
Download data: TXT, XLSX
Series
Accession:
GSE84738
ID:
200084738
5.

Microarray-based gene expression of rabbit basilar artery smooth muscle cells exposed to hemodynamic insult

(Submitter supplied) High-flow causes the remodeling of arteries, in which smooth muscle cells play an important role. To know the profile of smooth muscle gene expression under high-flow conditions in vivo, flow of rabbit basilar artery was increased by ligation of both common carotid arteries. Microarrays were performed to profile the gene expression of smooth muscle cells isolated from rabbit basilar artery. Expression profiles indicate 43603 differentially expressed genes in smooth muscle cells exposed to high-flow insult compared with the sham control, of which 1470 genes were upregulated and 780 genes downregulated using 2 fold-changes and P<0.05 as a cut-off.
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
6 Samples
Download data: TXT
Series
Accession:
GSE61212
ID:
200061212
6.

Gene expression from the New Zealand White rabbit calvarial defects treated with human particulated dentin

(Submitter supplied) In this study, human particulated dentin (HPD) was developed. The characteristic of HPD was examinated by XRD, EDX and cytotoxicity test. HPD was used to implant in the calvarial defects of New Zealand White rabbits. bone tissue and blood samples were taken at 3, 5 and 7 days post-implantation for microarray experiment. The gene expression profiles and signaling pathways were monitored using GeneSpring software and Ingenuity Pathways Analysis (IPA), respectively. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
6 Samples
Download data: TXT, XLS
Series
Accession:
GSE83553
ID:
200083553
7.

Adjunctive therapy with a phosphodiesterase-4 inhibitor improves INH response to pulmonary tuberculosis

(Submitter supplied) Current antibiotic regimen to treat tuberculosis (TB) is ineffective in fully eliminating the bacterial load and in alleviating disease pathology. We examined the usefulness of a phosphodiesterase-4 inhibitor (CC-11050) as an adjunctive to anti-TB drug Isoniazid (INH) to improve the outcome of treatment in a rabbit model of active pulmonary TB. Control of Mycobacterium tuberculosis (Mtb) growth, disease pathology and the global transcriptional response in Mtb-infected lungs of rabbits with or without CC-11050 treatment were studied. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
8 Samples
Download data: TXT
Series
Accession:
GSE74687
ID:
200074687
8.

Gene expression in experimental aortic coarctation and repair: candidate genes for therapeutic intervention?

(Submitter supplied) The objective of the current investigation was to use microarray techniques to quantify differentially expressed genes (DEGs) in the upstream aorta subjected to high arterial BP after surgical induction of CoA, and restoration of normal arterial BP after its correction. DEGs may offer additional insight into potential mechanisms of persistent CV morbidity despite successful surgical repair.
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
12 Samples
Download data: TXT, XLS, XLSX
Series
Accession:
GSE70687
ID:
200070687
9.

Transcriptomic study on the impact of Temporomandibular joint Internal derangement in the Condylar Cartilage of Rabbits

(Submitter supplied) Internal derangement (ID) in the temporomandibular joint (TMJ) compromises a group of clinical problems, and holds a relative high prevalence in populations. However, the temporal change in gene expression of condylar cartilage during continous ID remains unclear. The aim of current study is investigating the differential expressed gene pattern in condylar cartilage of rabbits with ID from 1 to 8 weeks. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
20 Samples
Download data: TXT
Series
Accession:
GSE66864
ID:
200066864
10.

Effect of embryonic and maternal genotype on foetal growth in rabbit

(Submitter supplied) The aim of this work was to evaluate the influence of maternal and embryonic genotype of two lines of rabbit selected by growth rate (line R) and litter size at weaning (line A) on foetal and placental growth. Embryos were recovered at 48 h of gestation from line R (46) and line A (40) donors and transferred to nulliparous recipient does (26 R and 24 A). Each recipient doe received six embryos into one oviduct from line R and six embryos form line A into the other. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
7 Samples
Download data: TXT
Series
Accession:
GSE62491
ID:
200062491
11.

Effect of Etanercept on Active Pulmonary Tuberculosis in Rabbits

(Submitter supplied) Treatment of chronic inflammatory diseases with tumor necrosis factor alpha antagonists has been associated with increased risk of tuberculosis (TB). We examined the usefulness of the rabbit model of active pulmonary TB for studying the impact of the human immune modulatory reagent etanercept on the host immune response. Control of Mycobacterium tuberculosis (Mtb) infection, disease pathology and the global transcriptional response in Mtb-infected lungs of rabbits were studied. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
24 Samples
Download data: TXT
Series
Accession:
GSE54442
ID:
200054442
12.

Intrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model

(Submitter supplied) Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in the fetal adaptive mechanism to IUGR given its high energetic demands. The energetic homeostasis depends on the correct interaction of several molecular pathways and the adequate arrangement of intracellular energetic units (ICEUs), where mitochondria interact with the contractile machinery and the main cardiac ATPases to enable a quick and efficient energy transfer. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
12 Samples
Download data: GPR
Series
Accession:
GSE37860
ID:
200037860
13.

Direct comparison of effects of slow-freezing and vitrification procedures on rabbit late blastocyst transcriptome

(Submitter supplied) Nowadays there is a need to improve cryopreservation protocols in both human assisted reproduction and domestic animal field. We wanted to compare the transcriptomic changes induced by two commonly used cryopreservation procedures (slow freezing and vitrification) on rabbit late blastocyst before the onset of implantation. We recovered rabbit morulae at day 3 of development, freezing or vitrified and transferred them into recipient maternal tracts till day 6 of development. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
3 Samples
Download data: TXT
Series
Accession:
GSE50979
ID:
200050979
14.

Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits

(Submitter supplied) In our rabbit model of pulmonary tuberculosis, infection with Mtb HN878, a hyper-virulent W-Beijing strain, results in progressive cavitary disease. However, infection of rabbit lungs with Mtb CDC1551, a hyper-immunogenic strain is effectively controlled overtime, establishing latent Mtb infection. Using these two Mtb strains, we tested the hypothesis that the initial host response in the lungs within hours of infection determines later outcome. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
8 Samples
Download data: TXT
Series
Accession:
GSE49947
ID:
200049947
15.

Spontaneous Latency in a Rabbit Model of Pulmonary Tuberculosis

(Submitter supplied) Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is an exquisitely adapted human pathogen capable of surviving for decades in the lungs of immune competent individuals in absence of disease. The World Health Organization estimates that 2 billion people have latent TB infection (LTBI), defined by positive immunologic response to Mtb antigens with no clinical signs of disease. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
12 Samples
Download data: TXT
Series
Accession:
GSE39219
ID:
200039219
16.

Kinetics of progressive pulmonary cavitary TB disease in rabbits

(Submitter supplied) Every year, tuberculosis kills nearly 1.8 million people through out the world. Though outcome of M. tuberculosis infection into active disease is determined by the host and bacterial factors, a strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response, the bacilli grows and mounts active disease. Activation of immune response following M. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
16 Samples
Download data: TXT
Series
Accession:
GSE33094
ID:
200033094
17.

PDE-4 inhibition alters gene expression and improves INH-mediated clearance of Mtb in rabbit lungs

(Submitter supplied) Tuberculosis kills nearly 2 million people through out the world, every year. The outcome of M. tuberculosis infection is determined by the host and bacterial factors. A strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response, the bacilli grows and mounts disease. Activation of immune response following M. tuberculosis infection affects the expression of many host genes that are involved in the production of immune system molecules such as cytokines, chemokines, surface receptors and transcriptional regulators that manifest in the change of subsequent cellular events, including chemotaxis and proliferation of effector cells. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by array
Platform:
GPL13288
12 Samples
Download data: TXT
Series
Accession:
GSE27992
ID:
200027992
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