GEO DataSets

(Submitter supplied) We performed gene set enrichment and differential expression analysis to identify biological pathways associated with locoregional recurrence in primary breast tumors. A custom Affymetrix microarray genechip was used to assess the gene expression of each tumor sample.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

637 Samples

Download data: CEL

(Submitter supplied) Mechanisms of poor responses to vaccines remain unknown. Hepatitis B virus-naïve elderly subjects received three vaccines, including a vaccine against hepatitis B virus (HBV). Transcriptomic profilling of blood collected pre-vaccination and post-vaccination was performed in order to identify candidate biomarkers of antibody response to the different vaccines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

173 Samples

Download data: CEL

(Submitter supplied) mRNA expression profiles for 106 primary breast carcinomas

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

100 Samples

Download data: CEL

(Submitter supplied) We present a novel approach for investigating transcriptomic differences between primary colorectal cancers (CRC) and distant CRC metastases, which may help to identify primaries at high risk for future dissemination and to inform the development of metastasis-targeted therapies. Eliminating tissue specificity of the “host” organs where tumors are located and adjusting for confounders such as exposure to chemotherapy and radiation, allows for an effective comparison of primary CRC and metastatic lesion transcriptomes at both the gene and pathway levels. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

1135 Samples

Download data: CEL, CSV, TXT, XLS

(Submitter supplied) Clinically annotated GEPs of 366 primary resected breast tumors ranked by a 12 gene chemokine score

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

366 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL15048 GPL11154 GPL22404

326 Samples

Download data: CEL, RCC

(Submitter supplied) Background: The KRAS gene is mutated in about 40% of colorectal cancer (CRC) cases, which has been clinically validated as a predictive mutational marker of intrinsic resistatnce to anti-EGFR inhibitor (EGFRi) therapy. Since nearly 60% of patients with a wild type KRAS fail to respond to EGFRi treatment, there is a need to develop more reliable molecular signatures to better predict response. Here we address the challenge of adapting a gene expression signature predictive of RAS pathway activation, created using fresh frozen (FF) tissues, for use with more widely available formalin fixed paraffin-embedded (FFPE) tissues. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

54 Samples

Download data: CEL

(Submitter supplied) Background: The KRAS gene is mutated in about 40% of colorectal cancer (CRC) cases, which has been clinically validated as a predictive mutational marker of intrinsic resistatnce to anti-EGFR inhibitor (EGFRi) therapy. Since nearly 60% of patients with a wild type KRAS fail to respond to EGFRi treatment, there is a need to develop more reliable molecular signatures to better predict response. Here we address the challenge of adapting a gene expression signature predictive of RAS pathway activation, created using fresh frozen (FF) tissues, for use with more widely available formalin fixed paraffin-embedded (FFPE) tissues. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

54 Samples

Download data: CEL

(Submitter supplied) Mechanisms of poor responses to vaccines remain unknown. Hepatitis B virus-naïve elderly subjects received three vaccines, including a vaccine against hepatitis B virus (HBV). Pre-vaccination high dimensional analyses of blood using transcriptional profiling and flow cytometry revealed that subjects having increased memory B cell frequencies and higher expression of genes downstream of B cell receptor signaling responded more strongly to the HBV vaccine whereas subjects having higher expression of inflammatory related genes and greater numbers of activated innate immune cells showed a weaker response to this vaccine. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

169 Samples

Download data: CEL

(Submitter supplied) While mutations in the KRAS oncogene are amongst the most prevalent in human cancer, there are few successful treatments to target these tumors. It is also likely that heterogeneity in KRAS-mutant tumor biology significantly contributes to the response to therapy. We hypothesized that presence of commonly co-occurring mutations in STK11 and TP53 tumor suppressors may represent a significant source of heterogeneity in KRAS-mutant tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

442 Samples

Download data: CEL

(Submitter supplied) Microarray analysis of 63 patients with pancreatic cancer tissues resulted in the identification of a 15-gene signature to predict overall survival

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

63 Samples

Download data: CEL

(Submitter supplied) In order to evaluate pathways that drive the development of ovarian cancer, we compared Affymetrix expression profiles from normal ovarian surface epithelium to those from primary ovarian carcinomas.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

69 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Other

Platforms:

GPL15048 GPL19394

51 Samples

Download data: CEL

(Submitter supplied) To exlore whether candidate target genes of certain miRNAs are differentially expressed in high-risk versus low-risk IPMN tissue.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

23 Samples

Download data: CEL

(Submitter supplied) The Lung3 data set consists of 89 NSCLC patients that were treated at MAASTRO Clinic, The Netherlands. For these patients pretreatment CT scans, tumour delineations and gene expression profiles were available. We used this data set to associate imaging features with gene-expression profiles.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

89 Samples

Download data: CEL

(Submitter supplied) Analysis of a panel of 41 human ovarian cancer cell lines for the study of ovarian cancer biology, drug response and drug sensitivity.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15048

41 Samples

Download data: CEL

(Submitter supplied) This is an alternate definition for the custom Rosetta/Merck Affymetrix array. For the canonical platform, see GPL10379. Protocol: See manufacturer website.

Organism:

Homo sapiens

16 Series

3415 Samples

Download data: CDF, TXT