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Items: 2

1.

Diphthamide modification of eEF2 is required for gut tumor-like hyperplasia induced by oncogenic Ras

(Submitter supplied) Eukaryotic elongation factor 2 (eEF2) undergoes a unique post-translational modification called diphthamidation. Although eEF2 diphthamidation is highly conserved, its pathophysiological function is still largely unknown. To elucidate the function of diphthamidation in tumor, we examined the involvement of diphthamidation pathway enzyme Dph5 in tumor progression in Drosophila adult gut. Expression of oncogenic RasV12 in gut intestinal stem cells (ISCs) and enteroblasts (EBs) causes hypertrophy and disruption of gut epithelia, and shortened lifespan. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Platform:
GPL17277
14 Samples
Download data: TXT
Series
Accession:
GSE141201
ID:
200141201
2.

The gene expression changes in darkcd4 apoptosis-deficient mutant flies

(Submitter supplied) Apoptosis is required not only for proper morphogenesis and tissue size regulation during development, but also for removing damaged or unwanted cells to maintain homeostasis. Apoptosis is mainly executed by evolutionally-conserved signaling process including caspases and its activator, dark. We performed microarray analysis of darkcd4 mutant flies to reveal the changes in gene expression. We found the elevated immune reaction, suggesting that inflammatory response was triggered by necrosis in darkcd4 .
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Platform:
GPL17277
8 Samples
Download data: TXT
Series
Accession:
GSE47853
ID:
200047853

Supplemental Content

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