GEO DataSets

(Submitter supplied) HIV-1 infection begins with binding of the viral envelope glycoprotein Env to the host receptor CD4, triggering a series of conformational changes that lead to fusion of the virus and cell membranes. Env, a trimer of gp120 and gp41 subunits, occupies a ‘closed’ conformation with contacts between gp120 subunits at the apex, and transitions through an ‘open’ conformation with the gp120 subunits spread apart following CD4 binding. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platforms:

GPL22068 GPL23868

21 Samples

Download data: XLSX

(Submitter supplied) The HIV-1 genome gains access to the inside of a cell via the mechanism of the viral spike protein Env, which undergoes a series of major conformational rearrangements after binding target receptors that ultimately drive virus-cell membrane fusion. Env is expressed as a heterogenous ensemble of conformations, which can inappropriately misdirect the host immune response towards the production of non-protective, strain-specific antibodies. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL22068

22 Samples

Download data: XLSX

(Submitter supplied) Nucleocapsid (NC) CLIP-seq experiments were conducted on wild-type and eccentric HIV-1 virions generated in the presence of allosteric integrase inhibitor, BI-B2.

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL22068

4 Samples

Download data: TXT

(Submitter supplied) Integrase CLIP-seq experiments were conducted on wild-type and eccentric HIV-1 virions generated in the presence of allosteric integrase inhibitors and IN K264/266A and R269/K273A mutations

Organism:

Human immunodeficiency virus 1

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL22068 GPL20319

5 Samples

Download data: TXT