GPL22370[Accession] - GEO DataSets

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Select item 2001799201.

Longitudinal Study of Transcriptomic Changes Occurring Over the Course of CHOP Treatment in Canine Lymphoma

(Submitter supplied) The standard treatment for canine lymphoma (cL) is the CHOP chemotherapy protocol. Most cL patients treated with CHOP initially achieve remission but the duration varies and the majority of dogs eventually relapse with a multidrug resistant phenotype. This study assesses changes in gene expression occurring in cL tumor cell populations over the course of CHOP treatment. We measured gene expression using RNA-Seq on 15 cL patient samples taken prior to treatment and again 6 weeks into treatment.

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22370
30 Samples

Download data: TSV

Series

Accession:: GSE179920

ID:: 200179920

SRA Run Selector

Select item 2001667122.

A knockout mutation associated with juvenile paroxysmal dyskinesia in Markiesje dogs indicates SOD1 pleiotropy

(Submitter supplied) A juvenile form of paroxysmal dyskinesia segregated in the Markiesje dog breed. Affected pups exhibited clinical signs of a severe tetraparesis, dystonia, cramping and falling over when trying to walk. In most cases the presentation deteriorated within weeks and elective euthanasia was performed. Pedigree analysis indicated autosomal recessive inheritance. Genome-wide association and homozygosity mapping of 5 affected dogs from 3 litters identified the associated locus on chromosome 31 in the region of SOD1. more...

Organism:: Canis lupus familiaris

Type:: Genome variation profiling by high throughput sequencing

Platform:: GPL22370
5 Samples

Download data: VCF

Series

Accession:: GSE166712

ID:: 200166712

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001574363.

An Evolutionary Cancer Epigenetic approach revealed DNA hypermethylation of Ultra-Conserved Non-coding Elements in squamous cell carcinoma of different mammalian species

(Submitter supplied) Background: Ultra-Conserved-Non-coding Elements (UCNEs) are genomic sequences that exhibit >95% sequence identity between human, mammals, birds, reptiles and fishes. Recent findings reported their functional role in cancer. Aim of this study was to evaluate their DNA methylation modifications in squamous cell carcinoma (SCC) from different mammal species Methods: Fifty SCC from 26 humans, 17 cats, 3 dogs, 1 horse, 1 bovine, 1 badger and 1 porcupine were investigated. more...

Organism:: Felis catus; Bos taurus; Homo sapiens; Canis lupus familiaris; Equus caballus; Meles meles; Hystrix cristata

Type:: Methylation profiling by high throughput sequencing

7 related Platforms
120 Samples

Download data: XLSX

Series

Accession:: GSE157436

ID:: 200157436

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001308744.

RNA-Seq analysis of gene expression in 25 cases of canine lymphoma undergoing CHOP chemotherapy

(Submitter supplied) Canine lymphoma is the most common hematological cancer in dogs and shares many molecular and clinical characteristics with human Non-Hodgkin lymphoma (NHL). The standard treatment for canine lymphoma is the “CHOP” sequential multiagent chemotherapy protocol consisting of Cyclophosphamide, Doxorubicin (Hydroxydaunorubicin), Vincristine (Oncovin™), and Prednisone. Approximately 70 - 85% of patients treated with CHOP achieve clinical remission. more...

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22370
25 Samples

Download data: TSV

Series

Accession:: GSE130874

ID:: 200130874

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001168815.

Malignant canine mammary epithelial cells shed exosomes containing differentially expressed microRNA that regulate oncogenic networks

(Submitter supplied) Breast (mammary) cancers in human (BC) and canine (CMT) patients share clinical, pathological, and molecular similarities that suggest dogs may be a useful translational model. Many cancers, including BC, shed exosomes that contain microRNAs (miRs) into the microenvironment and circulation, and these may represent biomarkers of metastasis and tumor phenotype. Three normal canine mammary epithelial cell (CMEC) cultures and 5 CMT cell lines were grown in serum-free media. more...

Organism:: Canis lupus familiaris

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL20988 GPL22370
8 Samples

Download data: XLSX

Series

Accession:: GSE116881

ID:: 200116881

SRA Run Selector

Select item 2000860596.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Canis lupus familiaris; Mus musculus; Heterocephalus glaber; Macaca mulatta

Type:: Methylation profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL24046 GPL13534 GPL22370
84 Samples

Download data: TXT

Series

Accession:: GSE86059

ID:: 200086059

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000860587.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

(Submitter supplied) We used buccal samples from two different dog breeds with well established differences in average lifespan to perform genome-scale identification of ageing-associated differentially methylated positions (aDMPs) in a total of 48 different dogs. A significant proportion of aDMPs that gained methylation with age replicated in an independent cohort. Furthermore, we also show that human aDMPs show similar ageing-associated dynamics at the homologous genomic regions in the dog. more...