GEO DataSets

(Submitter supplied) We report that blood cell-free DNA as a promising biomarker for the diagnosis of sepsis and for the prediction of 28-day mortality of ICU patients by integrating both human and microbial cfDNA components.

Organism:

Homo sapiens; blank sample

Type:

Other

Platforms:

GPL29107 GPL18573

136 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

blank sample; Homo sapiens

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

4 related Platforms

355 Samples

Download data: COV

(Submitter supplied) Global changes in DNA methylation are observed in several developmental and disease contexts, and single-cell analyses are beginning to reveal the heterogeneous regulation of these processes. However, these studies are limited by the poor alignment rates and high sequencing demands associated with single-cell analysis of DNA methylation. We present single-cell transposable element methylation sequencing (scTEM-seq) for cost-effective estimation of global DNA methylation levels. more...

Organism:

blank sample; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18573 GPL29107

161 Samples

Download data: TXT

(Submitter supplied) In a phase 3 trial in African infants/children, the RTS,S/AS01 (GSK) vaccine showed moderate efficacy against clinical malaria. We aimed to identify RTS,S/AS01-induced signatures associated with clinical malaria by analyzing antigen-stimulated peripheral blood mononuclear cells sampled from a subset of trial participants at baseline and month 3 (one month post-final dose). RTS,S/AS01 vaccination was associated with downregulation of B-cell and monocyte-related blood transcriptional modules (BTMs) and upregulation of T-cell related BTMs, as well as higher month 3 (vs baseline) (CSP)-specific CD4+ T-cell responses. more...

Organism:

blank sample; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL29107 GPL18573

1925 Samples

Download data: TSV

(Submitter supplied) Transcriptomic signatures, or biomarkers, of toxicity can facilitate rapid mechanistic analysis of chemicals using high-content transcriptomic data and identification of potential hazards to human health. We developed an 81-gene transcriptomic biomarker, named TGx-HDACi, to detect histone deacetylase inhibitors (HDACi) in TK6 human lymphoblastoid cells after 4 hours of chemical exposure. This work leveraged an established transcriptomic biomarker of DNA damage, TGx-DDI, which was developed by Heng Hong Li et al. more...

Organism:

Homo sapiens; blank sample

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL29107 GPL18573

128 Samples

Download data: TXT

(Submitter supplied) Plasmacytoid dendritic cells (pDCs) can rapidly produce interferons and other soluble factors in response to extracellular viruses or virus mimics such as CpG-containing DNA. pDCs can also recognize live cells infected with certain RNA viruses, but the relevance and functional consequences of such recognition remain unclear. We studied the response of primary DCs to the prototypical persistent DNA virus, the human cytomegalovirus (CMV). more...

Organism:

blank sample; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18573 GPL29107

96 Samples

Download data: TXT

(Submitter supplied) Using multicolor lineage tracing, in vivo time-lapse imaging and single cell transcriptional profiling in a mouse glioma model, we identify tumour blood endothelial cells carrying a Csf1r lineage trace. These Csf1r lineage endothelial cells (CLECs) form up to 10% of the tumour vasculature and express endothelial cell markers as well as a unique set of genes that can also be found in single cell transcriptome data of tumour endothelium from various human tumours.

Organism:

blank sample; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL29107 GPL19057

768 Samples

Download data: TXT