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Items: 1 to 20 of 56

1.

Integrative Genomics Reveals Mechanisms of Copy Number Alterations Responsible for Transcriptional Deregulation in Colorectal Cancer

(Submitter supplied) To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic hybridization (aCGH), and array-based global gene expression profiling on 31 primary carcinomas and 15 established cell lines. Importantly, aCGH showed that the genomic profiles of primary tumors are recapitulated in the cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6848 GPL6480
50 Samples
Download data: TXT
Series
Accession:
GSE126053
ID:
200126053
2.

Mesenchymal Transition in Human Mesothelial Cells In Vitro and Ex Vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6480 GPL6848
42 Samples
Download data: TXT
Series
Accession:
GSE92455
ID:
200092455
3.

Mesenchymal Transition in Human Mesothelial Cells In Vitro and Ex Vivo [TGF-β1 and IL-1β treatment]

(Submitter supplied) Peritoneal dialysis (PD) is an effective form of renal replacement therapy. A significant proportion of patients who initiate PD suffer from PD-related clinical complications, including peritoneal membrane damage, which may limit the duration of treatment. Mesothelial-to-mesenchymal transition (MMT) significantly contributes to the peritoneal dysfunction related to PD. Hence, we analyzed the genetic reprograming of the MMT-process with the aim to identify new biomarkers that may be tested in PD-patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
4 Samples
Download data: TXT
Series
Accession:
GSE92454
ID:
200092454
4.

KSHV miRNA transfection and inhibition

(Submitter supplied) Transcriptional profiling of BJAB cells transfected with KSHV miRNAs and BCBL cells treated with KSHV miRNA inhibitors. To identify host RNA targets of KSHV miRNAs, we took advantage of the observation that RNAs targeted by miRNAs often display small reductions in their steady-state levels, perhaps as a result of their impaired translation. Accordingly, we examined cellular transcript accumulation by array-based expression profiling under four sets of conditions in which KSHV miRNAs were expressed or inhibited.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
63 Samples
Download data: TXT
Series
Accession:
GSE76472
ID:
200076472
5.

Blockade of interferon-γ normalizes IFN regulated gene expression in subjects with systemic lupus erythematosus (SLE)

(Submitter supplied) Normal donor blood was incubated with or without IFN-g stimulation to establish an IFN-g gene signature. Systemic lupus erythematosus subjects were treated with placebo or AMG 811, a therapeutic anti-IFN--g antibody, and changes in the IFN--g signature in whole blood of these subjects was measured.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6848 GPL6480
125 Samples
Download data: TXT, XLS
Series
Accession:
GSE78193
ID:
200078193
6.

TK6 toxicogenomics reference database

(Submitter supplied) TK6 cells were exposed to various perturbations and then the transcriptome profiles were collected at 4 hours to assemble a reference database to generate a Genotoxic / Nongenotoxic classifier using the nearest shrunken centroids method.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6480 GPL6848 GPL14550
64 Samples
Download data: TXT
Series
Accession:
GSE58431
ID:
200058431
7.

miR-K12-6-5p expression changes of human transcripts

(Submitter supplied) Transcriptional profiling of BJAB cells expressing miR-K12-6-5p. To identify host RNA targets of KSHV miRNAs, we took advantage of the observation that RNAs targeted by miRNAs often display small reductions in their steady-state levels, perhaps as a result of their impaired translation. Accordingly, we examined cellular transcript accumulation by array-based expression profiling under four sets of conditions in which KSHV miRNAs were expressed.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
4 Samples
Download data: TXT
Series
Accession:
GSE65148
ID:
200065148
8.

Gene Expression Test for Operational Renal Allograft Tolerance

(Submitter supplied) Genomic Analysis of more than 400 patients from multi-center transplant programs and clinical trials provides a non-invasive QPCR based gene expression test for operational renal allograft tolerance
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6848 GPL6480
31 Samples
Download data: TXT
Series
Accession:
GSE45218
ID:
200045218
9.

Preclinical analysis of acquired resistance after prolonged efficacious metronomic oral topotecan chemotherapy plus pazopanib therapy in advanced ovarian carcinoma

(Submitter supplied) An alternative or follow-up adjunct to conventional maximum tolerated dose (MTD) chemotherapy now in advanced phase III clinical trial assessment is metronomic chemotherapy?the close regular administration of low doses of drug with no prolonged breaks. A number of preclinical studies have shown metronomic chemotherapy can cause long term survival of mice with advanced cancer, including metastatic disease, in the absence of overt toxicity, especially when combined with targeted antiangiogenic drugs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
12 Samples
Download data: TXT
Series
Accession:
GSE54621
ID:
200054621
10.

Gene expression in human peripheral blood 48 hours after exposure to ionizing radiation

(Submitter supplied) Analysis of human peripheral blood 48 hours after irradiation ex vivo with graded doses of gamma rays. Results have been used in building and testing classifiers to predict exposure dose for use in radiological triage, and also provide insight into immune cell responses. Results were compared with those from earlier times and from patients exposed in vivo.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6480 GPL6848
75 Samples
Download data: TXT
Series
Accession:
GSE44201
ID:
200044201
11.

Potential Roles of miR-29a in the Molecular Pathophysiology of T-Cell Acute Lymphoblastic Leukemia

(Submitter supplied) The miR-29 family is an important player in the molecular pathophysiology of distinct types of cancer, with roles that seems to depend on cellular context. Reduced miR-29 levels are associated with more aggressive disease and its overexpression in cancer and leukemic cell lines inhibits proliferation. In contrast, its overexpression in hematopoietic progenitors, promotes leukemogenesis. We explored the potential roles of miR-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia (T-ALL). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
4 Samples
Download data: TXT
Series
Accession:
GSE48063
ID:
200048063
12.

Gene expression profiling of HIV-1 latently infected memory CD4+ T cells

(Submitter supplied) Suppressive HAART does not eradicate HIV-1 and viral DNA persists as a stably integrated form in the absence of viral particle production. As a consequence, latent reservoirs are refractory to antiretroviral drugs and invisible to immune surveillance. The largest latent reservoir consists of resting memory CD4+ T cells. These cells can resume viral infection when activated through antigen recognition, causing bursts of viremia (blips). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
4 Samples
Download data: TXT
Series
Accession:
GSE40550
ID:
200040550
13.

Gene expression signatures for MMP19 full length cDNA transfection in A549 cells.

(Submitter supplied) To further understand the role of MMP19 in IPF, particularly in genotype and phenotype changes, we have employed whole genome microarray expression profiling as a discovery platform to identify the target genes of MMP19 in epithelial cells. Gene expression analysis showed that 8358 genes were differentially expressed at p-value 0.05 level and 748 genes were significantly changed with MMP19 expression, which covers matrix protien and cell proliferation, motality and phenotype changes (EMT). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
8 Samples
Download data: TXT
Series
Accession:
GSE34994
ID:
200034994
14.

Human lymphoblastoid cell lines: controls vs. patients with autism

(Submitter supplied) Autism spectrum disorders (ASDs) are relatively common neurodevelopmental conditions whose biological basis has been incompletely determined. We analyzed the metabolic profile of lymphoblastoid cell lines from patients with ASDs and normal individuals, using the Biolog Phenotype plates. To validate our metabolic findings, we utilized the Agilent Whole Human Genome Oligo Microarray to evaluate the level of gene expression in the tested cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6480 GPL6848
34 Samples
Download data: TXT
Series
Accession:
GSE43076
ID:
200043076
15.

The transcriptional profile of Langhans-like multinucleated giant macrophages: Collapse of the inflammatory and immune responses

(Submitter supplied) Monocytes/macrophages have the ability to fuse in multinucleated giant cells (MGCs). Except for osteoclasts that resorb bones on large surfaces, the function of other macrophage-derived MGCs, which appear under pathological situations associated with granulomatous inflammation such as tuberculosis, is not understood. Here we deciphered functions and gene expression profiles of MGCs obtained after stimulation of human monocytes with IFN-g and concanavalin A. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
12 Samples
Download data: TXT
Series
Accession:
GSE30273
ID:
200030273
16.

Placenta environment induces the differentiation of macrophages into multinucleated giant cells

(Submitter supplied) A major population of placenta macrophages represented throughout the pregnancy consists of CD14+ macrophages, but their characteristics remain badly understood. Here we purified from placentas at term CD14+ macrophages using positive selection. The phenotyping of CD14+ macrophages performed using flow cytometry revealed that placenta CD14+ macrophages expressed a series of markers distinct of those of circulating monocytes monocyte-derived macrophages. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
12 Samples
Download data: TXT
Series
Accession:
GSE29575
ID:
200029575
17.

Regulating the angiogenic balance in tissues

(Submitter supplied) A balance between angiogenesis inducers and inhibitors in the microenvironment controls the rate of new blood vessel formation. We hypothesized that fibroblasts, an important cellular constituent of the tissue stroma, secrete molecules that contribute to this balance. We further hypothesized that fibroblasts secrete molecules that promote angiogenesis when they are in a proliferative state and molecules that inhibit angiogenesis when they are not actively cycling (quiescent). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
12 Samples
Download data: TXT
Series
Accession:
GSE42681
ID:
200042681
18.

miR-K12-9 expression and inhibition

(Submitter supplied) Transcriptional profiling of BJAB cells expressing miR-K12-9 and BCBL cells treated with miR-K12-9 inhibitor. To identify host RNA targets of KSHV miRNAs, we took advantage of the observation that RNAs targeted by miRNAs often display small reductions in their steady-state levels, perhaps as a result of their impaired translation. Accordingly, we examined cellular transcript accumulation by array-based expression profiling under four sets of conditions in which KSHV miRNAs were expressed or inhibited.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
10 Samples
Download data: TXT
Series
Accession:
GSE40093
ID:
200040093
19.

Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis.

(Submitter supplied) The molecular events implicated in the development of endometrial carcinosarcoma remain poorly understood. Using complementary DNA microarrays, we analyzed a group of 15 endometrial carcinosarcomas and compared their gene expression profiles with those obtained from a group of 23 endometrioid endometrial carcinomas. We demonstrated changes in the expression of genes modulating processes such as the epithelial to mesenchymal transition, muscle differentiation, the expression of cancer/testis antigens, and immune response in endometrial carcinosarcomas. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL4133 GPL6848
38 Samples
Download data: TXT
Series
Accession:
GSE33723
ID:
200033723
20.

PPD stimulated PBMCs from tuberculosis patients, latent infectious individuals and healthy controls.

(Submitter supplied) Comprehensively compare the transcriptional difference in PPD stimulated PBMCs from individuals with different tuberculosis infectious status: tuberculosis patients, latent infectious individuals and healthy controls using the microarray analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6848
12 Samples
Download data: TXT
Series
Accession:
GSE27984
ID:
200027984
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