GEO DataSets

(Submitter supplied) Humans are exposed to both inorganic and organic mercury. While the toxicity of mercury is well established, much remains to be resolved about how different mercurials act at the molecular level. To address this issue, we employed a toxicogenomics approach using the nematode C. elegans. Using sub-, low- or high-toxic exposures of either HgCl2 or CH3HgCl the effects of these mercurials on steady-state mRNA levels for the entire genome were determined. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

24 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of N2 vs. nhr-8 mutant worms, aiming to identify direct and indirect targets of the nuclear receptor.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

14 Samples

Download data: TXT

(Submitter supplied) Elucidation of the biological role of H1 and HP1 in mammals has been difficult owing to the existence of a least 11 distinct H1 and three HP1 subtypes in mice. Therefore we decided to study the function of HP1 (HPL-1 and HPL-2) and H1 (HIS-24) related proteins in C. elegans, since hpls and his-24 deficient nematodes are viable. Global transcriptional analysis of the mutant animals revealed that expression of only a small number of genes was affected and HPLs, and HIS-24 appear to influence the expression of genes through either activation or repression. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

8 Samples

Download data: TXT

(Submitter supplied) Hormesis occurs when a low level stress elicits adaptive beneficial responses that protect against subsequent exposure to severe stress. Recent findings suggest that mild oxidative and thermal stress can extend lifespan by hormetic mechanisms. Here we show that the botanical pesticide plumbagin, while toxic to C. elegans nematodes at high doses, extends lifespan at low doses. Because plumbagin is a naphthoquinone that generates free radicals in vivo, we investigated whether it extends lifespan by activating an adaptive cellular stress response pathway. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

8 Samples

Download data: TXT

(Submitter supplied) Linker histone H1 and heterochromatin protein 1 (HP1) are essential components ofheterochromatin which contribute to the transcriptional repression of genes. It has been shown that the methylation mark on the histone H1 serves as a specific recognition code for the chromodomain of HP1, however, the functional role of the HP1/H1 complex remains elusive. Using C. elegans, we elucidate the function of the linker histone variant HIS-24 and heterochromatin proteins HPL/HP1 in the cooperative transcriptional regulation of immunerelevant and stress resistance genes. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

10 Samples

Download data: TXT

(Submitter supplied) Mutation generates the heritable variation that genetic drift and natural selection shape. In classical quantitative genetic models, drift is a function of the effective population size and acts uniformly across traits, while mutation and selection act trait-specifically. We identified thousands of quantitative trait loci (QTL) influencing transcript abundance traits in a cross of two C. elegans strains; although trait-specific mutation and selection explained some of the observed pattern of QTL distribution, the pattern was better explained by trait-independent variation in the intensity of selection on linked sites. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

208 Samples

Download data: TXT

(Submitter supplied) Reproductive cessation is perhaps the earliest aging phenotypes humans experience. Similarly, C. elegans' reproduction ceases in mid-adulthood. Although somatic aging has been studied in both worms and humans, mechanisms regulating reproductive aging are not yet understood. Here we show that TGF-beta Sma/Mab activity regulates reproductive aging transcriptionally separable from its regulation of body size growth. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

17 Samples

Download data: TXT

(Submitter supplied) To find genes downstream of the TGF-beta Sma/Mab pathway associated with body size regulation in C. elegans.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

4 Samples

Download data: TXT

(Submitter supplied) To find genes in C. elegans oocytes associated with reproductive aging.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

5 Samples

Download data: TXT

(Submitter supplied) To find genes downstream of the TGF-beta Sma/Mab pathway in C. elegans oocytes associated with reproductive aging.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

8 Samples

Download data: TXT

(Submitter supplied) To realistically evaluate the effects of the environment in space, it is necessary to understand the effects of external factors during sample transport from Earth to space. The present study focused on temperature, profiling the altered gene expression that develops under low cultivation temperatures in C. elegans, used as a space life science model. The 7903 genes were selected as differentially expressed genes, and divided into five sets with similar expression patterns using k-means clustering. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

12 Samples

Download data