|
| Status |
Public on Sep 01, 2010 |
| Title |
TGF-beta Sma/Mab signaling regulates a set of genes in oocytes associated with reproductive aging and another set in L4 associated with body size growth |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
|
| Summary |
Reproductive cessation is perhaps the earliest aging phenotypes humans experience. Similarly, C. elegans' reproduction ceases in mid-adulthood. Although somatic aging has been studied in both worms and humans, mechanisms regulating reproductive aging are not yet understood. Here we show that TGF-beta Sma/Mab activity regulates reproductive aging transcriptionally separable from its regulation of body size growth.
This SuperSeries is composed of the SubSeries listed below.
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| |
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| Overall design |
Refer to individual Series
|
| |
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| Citation(s) |
20946987 |
| |
| Submission date |
Aug 09, 2010 |
| Last update date |
Dec 28, 2012 |
| Contact name |
Shijing Luo |
| E-mail(s) |
shijingluo@gmail.com
|
| Organization name |
Princeton University
|
| Street address |
160 Carl Icahn Lab, Princeton University
|
| City |
Princeton |
| State/province |
NJ |
| ZIP/Postal code |
08544 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL7727 |
Agilent-015061 C. elegans Oligo Microarray 4x44K G2519F (Feature Number version) |
|
| Samples (17)
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| GSM575204 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #1 SL2.6.09 |
| GSM575205 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #2 SL2.6.09 |
| GSM575206 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #3 SL2.6.09 |
| GSM575207 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #4 SL2.6.09 |
| GSM575208 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #5 SL2.6.09 |
| GSM575209 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #6 SL2.6.09 |
| GSM575210 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #8 SL2.6.09 |
| GSM575211 |
sma-2;fem-1 oocyte D8 vs fem-1 oocyte D8 array #9 SL2.6.09 |
| GSM575212 |
sma-2x3 L4 vs N2 L4 #1 WS 4.6.07 |
| GSM575213 |
N2 L4 v sma-2x3 L4 #2 DF WS 4.6.07 |
| GSM575214 |
sma-2x3 L4 v N2 L4 #3 WS 4.6.07 |
| GSM575215 |
sma-4(e729) L4 v N2 L4 #1 WS 4.10.7 |
| GSM575216 |
fem-1 oocyte D3 vs fem-1 oocyte D8 array #3 SL9.13.08 |
| GSM575217 |
fem-1 oocyte D3 vs fem-1 oocyte D8 array #5 SL12.02.08 |
| GSM575218 |
fem-1 oocyte D3 vs fem-1 oocyte D8 array #6 SL12.02.08 |
| GSM575219 |
fem-1 oocyte D3 vs fem-1 oocyte D8 array #7 SL12.02.08 |
| GSM575220 |
fem-1 oocyte D3 vs fem-1 oocyte D8 array #8 SL12.02.08 |
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| This SuperSeries is composed of the following SubSeries: |
| GSE23446 |
Reproductive aging: sma-2;fem-1 day 8 oocyte vs fem-1 day 8 oocyte |
| GSE23447 |
Reproductive aging: fem-1 day 3 oocyte vs fem-1 day 8 oocyte |
| GSE23448 |
Body size regulation and TGF-beta Sma/Mab pathway: sma L4 vs N2 L4 |
|
| Relations |
| BioProject |
PRJNA131083 |
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