GEO DataSets

(Submitter supplied) Understanding the nature of the various glucose-derived signals for insulin secretion (both triggering and amplifying) is essential for gaining insight into the functional failure of the beta-cells in diabetes and the development of drugs for correcting this problem. The beta-cells uniquely couple changes in cellular metabolism to electrical activity and thus insulin release. In mice, beta-cell specific deletion of the von Hippel-Lindau (VHL) tumor suppressor protein leads to the activation of a HIF transcription program that includes genes involved in glycolysis, suppression of mitochondrial activity and lactate production. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3800

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

Analysis of pancreatic islet cells deficient for the von Hippel-Lindau tumor suppressor protein from 18 to 26 wk-old animals. Loss of Vhlh in beta-cells leads to impaired glucose tolerance and to abnormal insulin secretion. Results provide insight into the role of Vhlh in pancreatic beta cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 gender, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE11484

6 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4546 Series

40 Related Platforms

58941 Samples

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