GSE13130[Accession] - GEO DataSets

Select item 2000131301.

Langerhans cells from aryl hydrocarbon receptor deficient mice

(Submitter supplied) The arylhydrocarbon receptor is a ligand inducible transcription factor. Known to control xenobiotic metabolizing enzymes, it also affects - depending on the cell type - numerous other genes, either directly or indirectly. With respect to the immune system, persistent activation leads to immunosuppression. We asked how the AhR is involved in Langerhans cells. These antigen presenting cells of the skin are responsible for allergies against chemicals (thus xenobiotic metabolism might be relevant) and a recently detected endogenous ligand, FICZ made by UVB radiation from tryptophane, is particularly abundant in the skin. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3575
Platform:: GPL339
4 Samples

Download data: CEL

Series

Accession:: GSE13130

ID:: 200013130

Select item 35752.

Aryl hydrocarbon receptor deficiency effect on Langerhan cells

Analysis of Langerhan cells (LCs) lacking the aryl hydrocarbon receptor (AhR). LCs are Ag-presenting cells of the epidermis. AhR is a ligand-activated transcription factor involved in low molecular mass chemical metabolism and cell differentiation. Results provide insight into the role of AhR in LC.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL339
Series:: GSE13130
4 Samples

Download data: CEL

DataSet

Accession:: GDS3575

ID:: 3575

Select item 1000003393.

[MOE430A] Affymetrix Mouse Expression 430A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip Mouse Genome 430A 2.0 Array is accessioned in GEO as GPL8321. June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...