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Items: 1 to 20 of 26

1.

A novel approach to Alzheimer’s Disease treatment: HDACs & PDE5 inhibition

(Submitter supplied) Considering the numerous complex and different pathological mechanisms involved in Alzheimer´s disease (AD) progression, treatments targeting a single cause may lead to limited benefits. The goal of this study was the identification of a novel mode of action for this unmet need. Pharmacological tool compounds: suberoylanilide hydroxamic acid (SAHA) and tadalafil, targeting histone deacetylases (HDAC) and phosphodiesterase 5 (PDE5) respectively, were utilized simultaneously for in-vitro and in-vivo Proof-of-Concept (PoC). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
24 Samples
Download data: CEL
Series
Accession:
GSE62240
ID:
200062240

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Jan 30, 2013: annotation table updated with netaffx build 33 Protocol: See manufacturer's web site
Organism:
Mus musculus
1091 Series
7 Related Platforms
11048 Samples
Download data
Platform
Accession:
GPL16570
ID:
100016570

3.

Hippocampus CM-414. Biological replica 4

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with CM-414
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523488
ID:
301523488

4.

Hippocampus CM-414. Biological replica 3

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with CM-414
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523487
ID:
301523487

5.

Hippocampus CM-414. Biological replica 2

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with CM-414
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523486
ID:
301523486

6.

Hippocampus CM-414. Biological replica 1

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with CM-414
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523485
ID:
301523485

7.

Hippocampus SAHA and Tadalafil. Biological replica 7

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA and Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523484
ID:
301523484

8.

Hippocampus SAHA and Tadalafil. Biological replica 6

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA and Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523483
ID:
301523483

9.

Hippocampus SAHA and Tadalafil. Biological replica 5

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA and Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523482
ID:
301523482

10.

Hippocampus SAHA and Tadalafil. Biological replica 4

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA and Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523481
ID:
301523481

11.

Hippocampus SAHA and Tadalafil. Biological replica 3

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA and Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523480
ID:
301523480

12.

Hippocampus SAHA and Tadalafil. Biological replica 2

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA and Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523479
ID:
301523479

13.

Hippocampus SAHA and Tadalafil. Biological replica 1

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA and Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523478
ID:
301523478

14.

Hippocampus Tadalafil. Biological replica 3

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523477
ID:
301523477

15.

Hippocampus Tadalafil. Biological replica 2

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523476
ID:
301523476

16.

Hippocampus Tadalafil. Biological replica 1

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with Tadalafil
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523475
ID:
301523475

17.

Hippocampus SAHA. Biological replica 3

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523474
ID:
301523474

18.

Hippocampus SAHA. Biological replica 2

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523473
ID:
301523473

19.

Hippocampus SAHA. Biological replica 1

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with SAHA
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523472
ID:
301523472

20.

Hippocampus vehicle. Biological replica 7

Organism:
Mus musculus
Source name:
Mouse hippocampi after chronic treatment with saline
Platform:
GPL16570
Series:
GSE62240
Download data: CEL
Sample
Accession:
GSM1523471
ID:
301523471

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