GSM1379553[Accession] - GEO DataSets

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Items: 4

Select item 2000573241.

Gene expression analysis in the spleen of wild type, Sle1.3 (lupus mice) and Sle1.3 mice haplodeficient for E2-2 (exhibiting non functional pDCs)

(Submitter supplied) Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the production of antibodies to self-nucleic acids, immune complex deposition and tissue inflammation such as glomerulonephritis. Innate recognition of molecular complexes containing self-DNA and RNA and the ensuing production of type I interferons (IFN) contribute to SLE development. Plasmacytoid dendritic cells (pDCs) have been proposed as a relevant source of pathogenic IFN in SLE; however, their net contribution to the disease remains unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5421
Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE57324

ID:: 200057324

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 54212.

Transcription factor E2-2 haplodeficiency effect on systemic lupus erythematosus model: splenocytes

Analysis of splenocytes from WT, B6.Sle1.Sle3 (lupus mice) and B6.Sle1.Sle3 Tcf4+/− (Sle/het) mice haplodeficient for the transcription factor E2-2 (Tcf4). E2-2 is a specific regulator of plasmacytoid dendritic cell (pDC) development. Results provide insight into role of pDC in SLE pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL6246
Series:: GSE57324
8 Samples

Download data: CEL

DataSet

Accession:: GDS5421

ID:: 5421

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000062463.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site