GSM1523481[Accession] - GEO DataSets

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Items: 3

Select item 2000622401.

A novel approach to Alzheimer’s Disease treatment: HDACs & PDE5 inhibition

(Submitter supplied) Considering the numerous complex and different pathological mechanisms involved in Alzheimer´s disease (AD) progression, treatments targeting a single cause may lead to limited benefits. The goal of this study was the identification of a novel mode of action for this unmet need. Pharmacological tool compounds: suberoylanilide hydroxamic acid (SAHA) and tadalafil, targeting histone deacetylases (HDAC) and phosphodiesterase 5 (PDE5) respectively, were utilized simultaneously for in-vitro and in-vivo Proof-of-Concept (PoC). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
24 Samples

Download data: CEL

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Accession:: GSE62240

ID:: 200062240

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000165702.

[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Jan 30, 2013: annotation table updated with netaffx build 33 Protocol: See manufacturer's web site