GSM157123[Accession] - GEO DataSets

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Items: 4

Select item 2000068081.

HRI Protects Erythroid Precursors in iron deficiency and beta-Thalassemia by Maintaining GATA-1 and Fog-1 Expression

(Submitter supplied) Heme-regulated eIF2α kinase (HRI) is essential for the survival of erythroid precursors in iron and heme deficiency and it also plays a protective role in red blood cell diseases of erythroid protoporphyria and β-thalassemia. In this study, we demonstrated for the first time the impairment of GATA-1 and Fog-1 expressions in iron deficiency and the impairment of GATA-1 expression in β-thalassemia. Furthermore, HRI is necessary to maintain the GATA-1/Fog-1 induced functions in erythroid differentiation, cell cycle and cell survival by sustaining both expressions of GATA-1 and Fog-1 in iron deficiency and in β-thalassemia. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL96 GPL339
24 Samples

Download data: CEL

Series

Accession:: GSE6808

ID:: 200006808

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000029182.

Feedback control by the human microRNA, let-7, regulates expression of the RNA sielncing enzyme, Dicer

(Submitter supplied) let-7 regulates Dicer and HMGA2 expression and decrease the steady state levels of these genes Keywords: miRNA inhibition and overexpression

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL96 GPL339
24 Samples

Download data: CEL

Series

Accession:: GSE2918

ID:: 200002918

Analyze with GEO2R

Select item 1000003393.

[MOE430A] Affymetrix Mouse Expression 430A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip Mouse Genome 430A 2.0 Array is accessioned in GEO as GPL8321. June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...