GSM359311[Accession] - GEO DataSets

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Items: 3

Select item 2000144361.

P16INK4a mediated supperssion of telomerase in normal and malignant human breast cells

(Submitter supplied) The cyclin-dependent kinase inhibitor p16INK4a (CDKN2A) is an important tumor-suppressor gene frequently inactivated in human tumors. p16 suppresses the development of cancer by triggering an irreversible arrest of cell proliferation termed cellular senescence. Here, we describe another anti-oncogenic function of p16 in addition to its ability to halt cell cycle progression. We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and malignant breast epithelial cells. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL1454
27 Samples

Download data: GPR

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Accession:: GSE14436

ID:: 200014436

Analyze with GEO2R

Select item 1000014542.

RenLab ENCODE PCR tiling array

(Submitter supplied) 24,537 non-repetitive sequences that are greater than 100 bps within the 44 ENCODE regions were PCR amplified. All the purified PCR products in a total of 66 384-well plates were spoted on glass slide using a contact printer. There are a total of 48 blocks, with 23 x 23 dimension in each array. Keywords = ENCODE Keywords = PCR tiling array Keywords = Bing Ren