GEO DataSets

(Submitter supplied) HER2 gene amplification and protein overexpression (HER2+) define a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. Although gene expression profiling has identified an ERBB2 molecular subtype of breast cancer, it is clear that HER2+ tumors reside in all molecular subtypes and represent a genomically and biologically heterogeneous group. Genome-wide DNA copy number profiling, using BAC array comparative genomic hybridization (aCGH) were performed on 200 tumors with mixed clinical characteristics and amplification of HER2. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL9077 GPL7247 GPL4723

200 Samples

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(Submitter supplied) The 33k tiling BAC Array set contains 33,370 large-insert clones with complete genome coverage. The clone set consists of the 32k BAC clone library (GEO accession GPL4723) with additional clones located in the telomeric regions (Knight SJ et al., Am J Hum Genet 2000) and clones covering microdeletion syndromes (Vissers LE et al., Am J Hum Genet 2003). Protocol: Arrays were produced using amplified genomic DNA targets from BAC clones. more...

Organism:

Homo sapiens

4 Series

91 Samples

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