GEO DataSets

(Submitter supplied) Opioid abuse produces enduring associations between the drug euphoria and features of the drug-taking experience, and these powerful associations can trigger relapse in individuals recovering from opioid use disorder. We show here that the epigenetic enzyme, histone deacetylase 5 (HDAC5), functions in the nucleus accumbens (NAc) during active heroin use to limit future relapse-like behavior. Moreover, enhancing HDAC5 function in NAc dramatically suppresses context-associated and reinstated heroin seeking behaviors, but it does not impact sucrose seeking. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL22388

20 Samples

Download data: CEL, TXT

(Submitter supplied) Annotation was derived from the Affymetrix annotation file RTA-1_0.na36.rn6.transcript.csv: #%create_date=Wed Jun 8 16:48:57 2016 PDT #%chip_type=RTA-1_0 #%lib_set_name=RTA-1_0 #%lib_set_version=r1 #%genome-species=Rattus norvegicus #%genome-version=rn6 #%genome-version-ucsc=rn6 #%genome-version-ncbi=Rnor_6.0 #%genome-version-create_date=2014-07-30 #%genome-lifted-method=psl-map.pl #%genome-lifted_from-species=Rattus norvegicus #%genome-lifted_from-version-ucsc=rn6 #%genome-lifted_from-version-ncbi=Rnor_6.0 #%netaffx-annotation-date=2016-03-15 #%netaffx-annotation-netaffx-build=36 #%netaffx-annotation-data-type=transcript_cluster Protocol: See manufacturers website

Organism:

Rattus norvegicus

48 Series

710 Samples

Download data