GSM701437[Accession] - GEO DataSets

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Items: 3

Select item 2000283731.

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

(Submitter supplied) Pax5 is a critical regulator of B cell commitment. Here we identified direct Pax5 target genes by streptavidin-mediated ChIP-chip analysis of pro-B cells expressing in vivo biotinylated Pax5. By binding to promoters and enhancers, Pax5 directly regulates the expression of multiple transcription factor, cell surface receptor and signal transducer genes. One of the newly identified enhancers was shown by transgenic analysis to confer Pax5-dependent B-cell-specific activity to the Nedd9 gene controlling B cell trafficking. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL13366 GPL13123
29 Samples

Download data: PAIR

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Accession:: GSE28373

ID:: 200028373

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000131232.

NimbleGen_GenAu MB BCELL v5.0

(Submitter supplied) Custom array. genomic regions of potential pax5 target genes from mm8 including IGH and surrounding genes isothermal tiling oligos at 100bp designname: 2007-06-28_imp_igh_2_ChIP designid: 6006 Protocol: as described in www.nimblegen.com