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Items: 3

1.

PRC2-mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and monosomy 7 (CUT&Tag)

(Submitter supplied) Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) harboring both inv(3)/t(3;3) and monosomy 7 (-7) are highly aggressive myeloid cancers whose molecular pathogenesis and therapeutic vulnerability remain elusive. High throughput drug screens, CUT&Tag/RNA sequence and functional assays using human MDS/AML cells revealed that EZH2 inhibitors efficiently induce apoptosis preferentially in MDS/AML with inv(3)/t(3;3) and -7 through activation of GADD45γ-p38-p53 axis. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20795
24 Samples
Download data: BW
Series
Accession:
GSE270760
ID:
200270760

2.

HiSeq X Ten (Homo sapiens)

Organism:
Homo sapiens
2048 Series
35295 Samples
Download data
Platform
Accession:
GPL20795
ID:
100020795

3.

OCI-DS1

Organism:
Homo sapiens
Source name:
hematopoietic tissue
Platform:
GPL20795
Series:
GSE270760
Download data: BW
Sample
Accession:
GSM8351465
ID:
308351465

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db=gds|term=GSM8351465[Accession]|query=5|qty=2|blobid=MCID_670b93e5475a635e85e10935|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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