GEO DataSets

(Submitter supplied) Background: Alcohol misuse, binge drinking pattern, and gender-specific effects in the middle-aged population has been clearly underestimated. In the present study, we focused on understanding gender-specific effects of alcohol exposure on the gut-liver axis and the role of gut microbiota in modulating gender-specific responses to alcohol consumption. Methods: Fifty-two-week-old female and male C57BL/6 mice were fasted for 12 h, and then administered a single oral dose of ethanol (EtOH) (6 g/kg). more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL34367

11 Samples

Download data: CSV

(Submitter supplied) DOCK8 is required for T cell-dependent gut IgA by maintaining plasma cell metabolic fitness

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

60 Samples

Download data: TXT

(Submitter supplied) Microbiome dysregulation affects the estrogen metabolism (estrobolome) profile which in turns affects the immunological response. Estrogen hormone is an essential hormone that regulates the sexual activity in females as well as immune response in both sexes. Endometriosis is one of complicated disorder influnce the fertility of females due to escape of endometrial tissue into peritoneal cavity where the immunotoxicity will be undertaken. more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

synthetic construct; mouse gut metagenome; Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL21626 GPL21051 GPL17769

26 Samples

Download data: TSV, XLSX

(Submitter supplied) To determine how constitutively active autophagy in Becn1F121A mice affects the fecal microbiota, we performed a 16s analysis.

Organism:

synthetic construct; mouse gut metagenome

Type:

Other

Platforms:

GPL17769 GPL21051

2 Samples

Download data: TSV, XLSX

(Submitter supplied) We developed an analysis pipeline that can extract microbial sequences from Spatial Transcriptomic (ST) data and assign taxonomic labels, generating a spatial microbial abundance matrix in addition to the default host expression matrix, enabling simultaneous analysis of host expression and microbial distribution. We called the pipeline Spatial Meta-transcriptome (SMT) and applied it on both human and murine intestinal sections and validated the spatial microbial abundance information with alternative assays. more...

Organism:

mouse gut metagenome; Mus musculus

Type:

Other

Platforms:

GPL32554 GPL32553

10 Samples

Download data: PNG, RDS, TAR, TSV

(Submitter supplied) The intestinal microbiome was examined from fecal pellets of animals with genetic targeting of the BTLA inhibitory receptor and the TNFR superfamily member HVEM, or in animals treated with agonist antibodies specific for BTLA.

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

45 Samples

Download data: XLSX

(Submitter supplied) Microbial dysbiosis is a colorectal cancer (CRC) hallmark and contributes to inflammation, tumor growth, and therapy response. Gut microbes signal via metabolites, but how the metabolites impact CRC is largely unknown. We interrogated fecal metabolites associated with mouse models of colon tumorigenesis with varying mutational load. We found that microbial metabolites from healthy mice or humans were growth-repressive, and this response was attenuated in mice and patients with CRC. more...

Organism:

Bacteria; feces metagenome; synthetic construct; mouse gut metagenome

Type:

Other

4 related Platforms

71 Samples

Download data: TXT

(Submitter supplied) Effect of certain microorganisms on mouse gut microbial communities in aged group.

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

30 Samples

Download data: TXT

(Submitter supplied) The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD) patients. The vermiform appendix is a lymphoid tissue implicated in the storage and regulation of the gut microbiome. Here, we investigate changes in the functional microbiome in the appendix of PD patients relative to controls by metatranscriptomic analysis. In the PD appendix, we find microbial dysbiosis affecting lipid metabolism, particularly an upregulation of bacteria responsible for secondary bile acid synthesis. more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

40 Samples

Download data: CSV, TSV

(Submitter supplied) Purpose: Gut microbiota is associated with the progression of brain tumor. However, the alterations in the gut microbiota during glioma growth and temozolomide (TMZ) therapy remains to be understood. Methods: C57BL/6 male mice were implanted with GL261 glioma cells. TMZ/sodium carboxymethyl cellulose (SCC) was administered by gavage for five consecutive days (from 8 to 12 days after implantation). Fecal samples were collected before (T0) and on days 7 (T1), 14 (T2), and 28 (T3) after implantation. more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL22735

48 Samples

Download data: TXT, XLS

(Submitter supplied) We demonstrate that blueberry supplementation led to global changes in the gut microbiome, which could possibly contribute to physiological changes in mice

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

1 Sample

Download data: BIOM, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; mouse gut metagenome

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL21493 GPL22735

60 Samples

Download data

(Submitter supplied) The colon contains a dense metabolically potent microbiota. The colonic O-glycan-rich mucus has been recognized as a key barrier to prevent microbial intrusion, but how this system forms and functions remains unclear. Here, we discovered that the colon mucus is mainly forged by microbiota-dependent secretion of O-glycosylated Muc2 by goblet cells in the ascending colon, where it seamlessly encapsulates the fecal materials including the microbiota. more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL22735

30 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

mouse gut metagenome; Gallus gallus

Type:

Other; Expression profiling by high throughput sequencing

Platforms:

GPL27659 GPL23499

13 Samples

Download data: FNA

(Submitter supplied) Whether myogenesis is affected by the maternal gut dysbacteriosis still remains ambiguous. In this study, firstly we show elevated level of lipopolysaccharides (LPS) in a gut microbiota dysbiosis mouse model. Secondly, we demonstrate that the diameter of muscle fibres, limb development and somitogenesis were inhibited in both gut microbiota dysbiosis and LPS exposed mice and chicken embryos. These might be due to LPS disturbed the cell survival and the key genes which regulating the somitogenesis and myogenesis. more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL27659

7 Samples

Download data: FNA, TXT

(Submitter supplied) Bazedoxifene and conjugated estrogens (CE+BZA) combination has been shown to prevent visceral adiposity and weight gain after menopause. However, its interaction with the microbiota has yet to be examined. In the present study, we use several –omics technologies to characterize the effects of various estrogens on the health of gut-liver axis. As reported in previous studies, CE+BZA combination is very effective at preventing ovariectomy-induced weight gain in mice fed a high-fat diet. more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

68 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; mouse gut metagenome

Type:

Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL19964 GPL21051

29 Samples

Download data: RCC

(Submitter supplied) The development of neutralizing FVIII antibodies is the most serious complication of hemophilia A treatment. The currently known patient- and treatment-related risk factors for inhibitor development do not accurately predict this adverse event in all patients. The composition of the gut microbiota has been shown to influence immune mediated diseases at distant anatomical sites (e.g. lungs, brain and joints). more...

Organism:

mouse gut metagenome

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21051

17 Samples

Download data: CSV

(Submitter supplied) There are 10 mice in the experiment, named REC. The mice were fed with high salt diets (5% NaCl) for 4 weeks and then fed with normal salt diets for 4 weeks. Then extracted DNA from mice gastric flora to detect changes in the gastric flora of mice.

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

10 Samples

Download data: TXT