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Select item 43371.

Type 2 diabetic and hyperglycemic pancreatic islets

Analysis of pancreatic islets from type 2 diabetes (T2D) and non-diabetic cadaver donors. Glycemic control (HbA1c) levels also measured from the same individuals (normoglycemic: HbA1c < 6%; hyperglycemic: HbA1c ≥ 6%). Results provided insight into molecular basis of islet dysfunction in T2D.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state, 23 other sets

Platform:: GPL6244
Series:: GSE38642
63 Samples

Download data: CEL

DataSet

Accession:: GDS4337

ID:: 4337

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 59482.

Zipper-interacting protein kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of zipper-interacting protein kinase (ZIPK). ZIPK is phosphorylated and activated by Rho-associated kinase 1 (ROCK1). These results, together with those from GDS5659, provide further insight into ROCK1 and ZIPK functions.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE56819
6 Samples

Download data: CEL

DataSet

Accession:: GDS5948

ID:: 5948

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 59143.

YAP transcriptional regulator depletion effect on endothelial cells

Analysis of umbilical vein endothelial HUVEC cells depleted for the transcriptional regulator YAP. YAP binds to the SH3 domain of the transcriptional activator Yes. Results provide insight into the role of YAP in endothelial cell proliferation.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 agent, 2 protocol sets

Platform:: GPL6244
Series:: GSE61989
12 Samples

Download data: CEL

DataSet

Accession:: GDS5914

ID:: 5914

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58154.

Sunitinib effect on renal cancer xenograft tumors

Analysis of Kyoto University Renal Cancer (KURC) xenograft tumor models, KURC1, KURC2, KURC3, treated with sunitinib, a small molecule inhibitor of receptor tyrosine kinases that is used to treat RC. Results provide insight into molecular mechanisms underlying acquired sunitinib resistance in RC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 disease state, 3 individual sets

Platform:: GPL6244
Series:: GSE66346
9 Samples

Download data: CEL

DataSet

Accession:: GDS5815

ID:: 5815

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58125.

Staphylococcal alpha-toxin effect on airway epithelial cells

Analysis of bronchial epithelial cell lines 16HBE14o- (Hla-susceptible) and S9 (Hla-resistant) treated with S. aureus recombinant alpha-toxin (rHla) for 2 hrs. Results provide insight into molecular mechanisms underlying cell type-specific responses of airway epithelial cells to alpha-toxin.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 cell line sets

Platform:: GPL6244
Series:: GSE65018
8 Samples

Download data: CEL

DataSet

Accession:: GDS5812

ID:: 5812

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58116.

TGFβ1 effect on gingival fibroblasts pretreated with TGFβ-associated kinase 1 inhibitor 5Z-7-Oxozeanol

Analysis of cultured gingival fibroblasts pre-treated with TGFβ-associated kinase 1 (TAK1) inhibitor (5Z)-7-Oxozeanol for 45 min prior to treatment with TGFβ1. Results provide insight into the extent to which TAK1 mediates fibroproliferative responses in gingival fibroblasts in response to TGFβ1.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 protocol sets

Platform:: GPL6244
Series:: GSE65069
8 Samples

Download data: CEL

DataSet

Accession:: GDS5811

ID:: 5811

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58107.

Hypoxia effect on von Hippel Lindau-overexpressing renal cell carcinoma cells

Analysis of renal cell carcinoma (RCC) 786-O cells transfected with von Hippel Lindau (VHL)-overexpression vector and cultured under hypoxia conditions (1% O2) for 24 hours. Results provide insight into overlap and differences of VHL- and hypoxia-dependent molecular alterations in RCC.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol, 2 stress sets

Platform:: GPL6244
Series:: GSE65168
8 Samples

Download data: CEL

DataSet

Accession:: GDS5810

ID:: 5810

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58058.

Peptidyl-prolyl cis/trans isomerase Pin1 deficiency effect on prostate cancer cells

Analysis of prostate cancer (PC) cell lines LNCap (androgen-dependent) and DU145 (androgen-independent) following siRNA-mediated knockdown of Peptidyl-prolyl cis/trans isomerase Pin1. Results provide insight into molecular mechanisms underlying Pin1 modulation of both PC two cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 cell line, 3 protocol sets

Platform:: GPL6244
Series:: GSE67457
6 Samples

Download data: CEL

DataSet

Accession:: GDS5805

ID:: 5805

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56709.

Mesenchymal-to-amoeboid transition effect on Hs294T melanoma cells

Analysis of Hs294T melanoma cells following three different treatments that induce the mesenchymal to amoeboid transition (MAT) in melanoma cells: EphA2 overexpression, Ilomastat treatment, or RhoA activator Calpeptin treatment. Results provide insight into molecular mechanisms underlying MAT.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 protocol sets

Platform:: GPL6244
Series:: GSE52246
8 Samples

Download data: CEL

DataSet

Accession:: GDS5670

ID:: 5670

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 565910.

Rho-associated kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of Rho-associated kinase 1 (ROCK1). ROCK1 phosphorylates and activates zipper-interacting protein kinase (ZIPK). These results, together with those from GDSxxxx, provide further insight into ROCK1 and ZIPK functions.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE56819
6 Samples

Download data: CEL

DataSet

Accession:: GDS5659

ID:: 5659

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 561011.

Heritable pulmonary arterial hypertension: cardiac right ventricular wall

Analysis of biopsies of right ventricle (RV) from patients with pulmonary arterial hypertension (PAH) with bone morphogenetic protein receptor type II (BMPR2) mutation. Results provide insight into molecular mechanisms underlying the metabolic effects of mutant BMPR2 in PAH RVs.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 disease state sets

Platform:: GPL6244
Series:: GSE67492
6 Samples

Download data: CEL

DataSet

Accession:: GDS5610

ID:: 5610

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560612.

Androgen effect on runt-related transcription factor 1-deficient prostate cancer cell line

Analysis of androgen receptor (AR)-positive prostate cancer (PC) LNCaP cells depleted for runt-related transcription factor (RUNX1) by siRUNX1 transfection then treated with 10nM dihydrotestosterone (DHT). Results provide insight into the role of RUNX1 in AR-dependent PC.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE62454
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5606

ID:: 5606

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560013.

Acute myeloid leukemia cell line Kasumi-1 response to dasatinib treatment and withdrawal

Analysis of dasatinib-sensitive, KITmut t(8;21) AML cell line Kasumi-1 treated with dasatinib for 12 wks giving rise to R48 cells. After 1 wk of dasatinib cessation, R48 cells give rise to PR48 cells. Results provide insight into molecular effects of long-term dasatinib treatment on t(8;21) AML.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 3 cell line, 3 protocol sets

Platform:: GPL6244
Series:: GSE39073
9 Samples

Download data: CEL

DataSet

Accession:: GDS5600

ID:: 5600

Select item 554414.

Edelfosine effect on stimulated CD4+ T cells

Analysis of stimulated CD4+ T cells (derived from buffy coat PBMCs) treated with edelfosine at 3.3µg/ml. Edelfosine is a cytotoxic drug taken up by highly proliferating cells such as activated immune cells. Results provide insight into the molecular basis of edelfosine action in immune T cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 protocol sets

Platform:: GPL6244
Series:: GSE44392
12 Samples

Download data: CEL

DataSet

Accession:: GDS5544

ID:: 5544

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 549615.

miR-365 expression effect on lung adenocarcinoma cell line

Analysis of NCI-H441 adenocarcinoma cells expressing hsa-miR-365-2, a precursor of miR-365. Results identify targets of miR-365 and the role of miR-365 in the pulmonary transcriptional program responsible for lung development and malignancy.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL6244
Series:: GSE33672
4 Samples

Download data: CEL

DataSet

Accession:: GDS5496

ID:: 5496

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 545416.

Epidermal keratinocyte differentiation in vitro

Analysis of neonatal epidermal keratinocytes treated with 1.8 mM calcium for up to 48 hours. Results provide insight into the molecular mechanisms underlying the differentiation of epidermal keratinocytes.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 7 time sets

Platform:: GPL6244
Series:: GSE38628
14 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5454

ID:: 5454

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 545317.

GRHL3-depleted epidermal keratinocyte response to the induction of differentiation in vitro

Analysis of Grainyhead like 3 (GRHL3)-depleted neonatal epidermal keratinocytes following treatment with 1.8 mM calcium for 24 hours to induce differentiation. GRHL3 encodes a transcription factor. Results provide insight into the role of GRHL3 in keratinocyte differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL6244
Series:: GSE37049
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5453

ID:: 5453

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 545218.

MLL2-depleted epidermal keratinocyte response to the induction of differentiation in vitro

Analysis of MLL2-depleted neonatal epidermal keratinocytes following treatment with 1.8 mM calcium for 24 hours to induce differentiation. Histone H3K4 methyltransferase MLL2 is a trithorax group protein. Results provide insight into the role of MLL2 in keratinocyte differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL6244
Series:: GSE37570
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5452

ID:: 5452

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 544019.

Androgen effect on carboxyl terminal-binding protein 2-deficient prostate cancer cell line

Analysis of androgen receptor (AR)-positive LNCaP prostate cancer cells depleted for carboxyl terminal-binding protein 2 (CTBP2) then treated with the androgen, dihydrotestosterone (DHT). Results provide insight into the molecular effects of CtBP2 knockdown on AR-mediated gene regulation.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 4 genotype/variation sets

Platform:: GPL6244
Series:: GSE58309
10 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5440

ID:: 5440

Select item 542720.

Osteoarthritic acetabular labrum 3-D culture

Analysis of osteoarthritic labrum cells cultured for 7 days in a 3-dimensional alginate bead system. The acetabular labrum is a fibrocartilaginous structure that seals the hip joint. Results provide insight into hip OA-associated molecular changes in acetabular labrum cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state, 8 individual sets

Platform:: GPL6244
Series:: GSE60762
8 Samples

Download data: CEL

DataSet

Accession:: GDS5427

ID:: 5427

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