Similar studies for GEO DataSets (Select 1012) - GEO DataSets

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Items: 10

Select item 10121.

Idiopathic and scleroderma-associated pulmonary fibrosis derived fibroblasts response to TGFbeta

Analysis of adult lung fibroblasts treated with 4 ng/ml TGFbeta cytokine for 4 hours. Fibroblasts obtained from patients with idiopathic or scleroderma-associated pulmonary fibrosis. Results provide insight into the role of TGFbeta in pulmonary fibrosis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 disease state sets

Platform:: GPL8300
Series:: GSE1724
18 Samples

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DataSet

Accession:: GDS1012

ID:: 1012

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000017242.

TGFbeta lung fibroblasts

(Submitter supplied) The response to a 4 hour treatment with TGFbeta (4 ng/ml) was evaluated in lung fibroblasts derived from three controls (normal periphery of resected tumor), open lung biopsies from three patients with idiopathic pulmonary fibrosis (usual interstitial pneumonia pattern on biopsy) and from three patients with fibrosing alveolitis associated with systemic sclerosis (fibrotic non specific interstitial pneumonia pattern on biopsy). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1012
Platform:: GPL8300
18 Samples

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Series

Accession:: GSE1724

ID:: 200001724

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000408393.

Expression data from fibroblasts cultured from normal and fibrotic human lung tissue

(Submitter supplied) Pulmonary fibrosis develops as a consequence of environmentally induced lung injury and/or an inherent disease susceptibility causing fibroblast activation, proliferation and extracellular matrix deposition. The study was undertaken to characterise global gene expression in pulmonary fibroblasts to better understand the mechanisms underlying the fibrotic fibroblast phenotype.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4995
Platform:: GPL96
21 Samples

Download data: CEL

Series

Accession:: GSE40839

ID:: 200040839

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49954.

Scleroderma-associated interstitial lung disease patients: pulmonary fibroblasts

Analysis of lung fibroblasts isolated from biopsies, taken at the time of diagnosis, from patients with well-defined pulmonary fibrosis associated with systemic sclerosis (SSc-ILD). Results provide insight into the molecular mechanisms underlying the fibrotic fibroblast phenotype in SSc-ILD.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL96
Series:: GSE40839
21 Samples

Download data: CEL

DataSet

Accession:: GDS4995

ID:: 4995

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001365345.

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

(Submitter supplied) Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently been linked to epigenetic modifications. Here, we screened a small library of epigenetic small-molecule modulators to identify compounds capable of inhibiting or reversing TGFβ-mediated fibroblast activation. We identified pracinostat, an HDAC inhibitor, as a potent attenuator of lung fibroblast activation and confirmed its efficacy in patient-derived fibroblasts isolated from fibrotic lung tissue. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data: TXT

Series

Accession:: GSE136534

ID:: 200136534

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000124936.

A TGFB Responsive Gene Expression Signature is Associated With More Severe Skin and Lung Disease in Diffuse Scleroderma

(Submitter supplied) Primary dermal fibroblasts from patients with dSSc and healthy controls were treated with TGF beta for up to 24h and the genome-wide patterns of gene expression measured on DNA microarrays. 894 genes were identified as TGF beta-responsive in 4 independent cultures of dermal fibroblasts (2 healthy control and 2 dSSc patients). The 894 genes in the TGF beta-responsive signature are associated with induction of growth factor signaling, collagen synthesis and extracellular matrix deposition.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6848 GPL6480
40 Samples

Download data: GPR

Series

Accession:: GSE12493

ID:: 200012493

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000650117.

Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis

(Submitter supplied) To investigate effects on mRNA expression in mouse lung tissue through treatment with Ly, Su, Imatinib, irradiation and combinations of them.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
24 Samples

Download data: TXT

Series

Accession:: GSE65011

ID:: 200065011

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000053398.

Vanadium pentoxide induced gene expression in human lung fibroblasts

(Submitter supplied) Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V2O5 in vitro in order to identify candidate genes that could play a role in airway remodeling associated with V2O5-induced bronchitis. Gene expression was measured at various time points over a 24 hr period using the Affymetrix Human Genome U133A 2.0 Array. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2535
Platform:: GPL571
45 Samples

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Series

Accession:: GSE5339

ID:: 200005339

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 25359.

Vanadium pentoxide effect on lung fibroblasts: time course

Analysis of lung fibroblasts for up to 24 hours following exposure to vanadium pentoxide (V2O5). Exposure to V2O5 is a cause of occupational bronchitis. Results provide insight into the molecular mechanisms that contribute to airway remodeling associated with V2O5-induced bronchitis.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 agent, 5 time sets

Platform:: GPL571
Series:: GSE5339
45 Samples

Download data

DataSet

Accession:: GDS2535

ID:: 2535

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20003066710.

Microarray profiling reveals Integrated Stress Response is activated by Halofuginone in mammary epithelial cells

(Submitter supplied) The small molecule Halofuginone (HF) is a potent regulator of extracellular matrix (ECM ) gene expression and is unique in its therapeutic potential. While the basis for HF effects is unknown, inhibition of TGFb signaling and activation of the AAR have been linked to HF transcriptional control of a number of ECM components and amelioration of fibrosis and alleviation of autoimmune disease by regulation of Th17 cell differentiation, respectively. more...