Similar studies for GEO DataSets (Select 1316) - GEO DataSets

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Items: 20

Select item 13161.

GATA-1 variant role in Down syndrome megakaryocytic leukemias

Analysis of megakaryocytes and their progenitors from mutant E12.5 embryo liver expressing truncated transcription factor GATA-1. Results provide insight into the role of variant GATA-1 (GATA1s) in megakaryocyte hyperproliferation and Down syndrome (DS)-associated leukemias (TMD, DS-AMKL/DS-AML M7).

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type, 3 genotype/variation sets

Platform:: GPL1261
Series:: GSE2433
10 Samples

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DataSet

Accession:: GDS1316

ID:: 1316

Select item 2000024332.

Expression profiling of GATA-1 wild type and mutant fetal megakaryocytes

(Submitter supplied) Background: Children with Down syndrome (DS) are predisposed to acute megakaryoblastic leukemia (AMKL, or AML M7) and a related myeloid disorder, referred to as transient myeloproliferative disorder (TMD), or transient leukemia (TL). Recently, acquired mutations in the erythroid/megakaryocytic lineage-specific transcription factor GATA-1 have been identified in megakaryoblasts from virtually all DS patients with AMKL (DS-AMKL), as well as in nearly all DS neonates with TMD. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1316
Platform:: GPL1261
10 Samples

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Series

Accession:: GSE2433

ID:: 200002433

Select item 2000834493.

caArray_orkin-0038: Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling

(Submitter supplied) Individuals with Down syndrome (DS) are predisposed to develop acute megakaryoblastic leukemia (AMKL), characterized by expression of truncated GATA1 transcription factor protein (GATA1s) due to somatic mutation. The treatment outcome for DS-AMKL is more favorable than for AMKL in non-DS patients. To gain insight into gene expression differences in AMKL, we compared 24 DS and 39 non-DS AMKL samples. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
80 Samples

Download data: CEL

Series

Accession:: GSE83449

ID:: 200083449

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Select item 2000041194.

Expression profiling of acute megakaryoblastic leukemia

(Submitter supplied) mononuclear cells were isolated on a density gradient and RNA extracted using Trizol and the Promega SV column RNA purification. Affymetrix U133A chips were hybridised using standard procedures at the core facility of Dana Farber Cancer Institute. Keywords: disease state analysis

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
80 Samples

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Series

Accession:: GSE4119

ID:: 200004119

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Select item 2001815705.

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

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Series

Accession:: GSE181570

ID:: 200181570

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Select item 2001815696.

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis [ATAC-seq]

(Submitter supplied) The purpose of this study was to decipher the molecular function of ARID3A. We leveraged gene expression (RNA-Seq) and chromatin profiling (ATAC-Seq and CUT&RUN) to evaluate gene expression changes upon restoring Arid3a expression in the context of the Gata1s mutation and miR-125b overexpression

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
1 Sample

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Series

Accession:: GSE181569

ID:: 200181569

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Select item 2001815687.

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis [CUT&RUN]

Organism:: Mus musculus

Type:: Other

Platform:: GPL24247
5 Samples

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Series

Accession:: GSE181568

ID:: 200181568

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Select item 2001815678.

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE181567

ID:: 200181567

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Select item 2001697409.

Chromosome 21-encoded miR-125b cooperates with GATA1s in trisomy 21-associated megakaryoblastic leukemia by targeting the megakaryocytic transcription factor ARID3A III

(Submitter supplied) The purpose of this study was to decipher the gene expression changes in the ML-DS cell line CMK upon overexpression of ARID3A. For that, we used a doxycycline-inducible gene expression system to overexpress ARID3A

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: XLS

Series

Accession:: GSE169740

ID:: 200169740

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Select item 20016973910.

Chromosome 21-encoded miR-125b cooperates with GATA1s in trisomy 21-associated megakaryoblastic leukemia by targeting the megakaryocytic transcription factor ARID3A II

(Submitter supplied) The purpose of this study was to decipher the molecular network underlying the synergy between the GATA1s mutation and miR-125b. We used a doxycycline-regulated inducible system to determine gene expression changes associated with the expression of miR-125b.,

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
24 Samples

Download data: XLS

Series

Accession:: GSE169739

ID:: 200169739

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Select item 20016973811.

Chromosome 21-encoded miR-125b cooperates with GATA1s in trisomy 21-associated megakaryoblastic leukemia by targeting the megakaryocytic transcription factor ARID3A I

(Submitter supplied) The purpose of this study was to decipher the molecular network underlying the synergy between the GATA1s mutation and loss of Arid3a. We used gene expression profiling (RNA-Seq) to evaluate gene expression changes upon gain and loss of Arid3a in the context of the Gata1s mutation

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
17 Samples

Download data: XLS

Series

Accession:: GSE169738

ID:: 200169738

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Select item 20024370212.

Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis

(Submitter supplied) Patients with Down syndrome (DS, trisomy 21, T21) are at increased risk of transient abnormal myelopoiesis (TAM) and acute megakaryoblastic leukemia (ML-DS). Both TAM and ML-DS require prenatal somatic mutations in GATA1, resulting in the truncated isoform GATA1s. The mechanism by which individual chromosome 21 (HSA21) genes synergize with GATA1s for leukemic transformation is challenging to study, in part due to limited human cell models with wild type GATA1 or GATA1s. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
19 Samples

Download data: TSV

Series

Accession:: GSE243702

ID:: 200243702

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Select item 20001968113.

Global gene expression profile of primary human leukemic blasts

(Submitter supplied) The goal of this study is to define the global gene expression profile of primary leukemic blasts from patients with different forms of myeloid leukemia and different FAB subtypes. Here we report the global gene expression profile of 2 patients with AML FAB M5, 2 patients with AML FAB M7, 3 patients with Down syndrome AML FAB M7 and 3 patients with Down syndrome transient leukemia.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE19681

ID:: 200019681

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Select item 20001968014.

Identification of miR-125b-2 target genes

(Submitter supplied) The goal of this study is to define miR-125b-2 target genes in the hematopoietic system by genetic alteration of miR-125b expression levels. Here we report the identification of miR-125b-2 targets in the hematopoietic system by repressing miR125b in megakaryoblastic leukemia (AMKL) cell lines and overexpressing miR-125b-2 in hematopoietic stem and progenitor cells (CD34+-HSPCs)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE19680

ID:: 200019680

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Select item 20001668415.

Murine M7 leukemia derived from retroviral insertional mutagenesis of Gata1s fetal progenitors depends on IGF signaling

(Submitter supplied) The goal of this study is to derive a mouse model of human Down Syndrome (DS) megakaryocytic leukemia involving mutations in the hematopoietic transcription factor, GATA1 (called GATA1s mutation). We achieved this through transduction of Gata1s mutant fetal progenitors by MSCV-based retrovirus expressing a GFP marker, followed by in vitro selection (for immortalized cell lines), and then in vivo selection (for transformed cell lines) through transplantation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE16684

ID:: 200016684

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Select item 20001668216.

Murine M7 leukemia derived from retroviral insertional mutagenesis of Gata1s fetal progenitors

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE16682

ID:: 200016682

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Select item 20001667917.

Plag1 overexpression cooperates with Evi1 overexpression and Gata1s mutation in leading to M7 leukemia

(Submitter supplied) The goal of this study is to develop a Plag1 signature and determine how its overexpression contributes to leukemogenesis. To study this, we transduced an immortalized (but not transformed) cell line (derived from Gata1s mutant fetal liver progenitor through insertional mutagenesis) by Plag1-expressing retrovirus. This turned a non-transformed cell line to a leukemogenic cell line. To study whether Plag1 overexpression led to deregulation of signaling pathways that may contribute to leukemic transformation, we generated microarray gene expression profiles of this cell line transduced with either Plag1 or the empty vector.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE16679

ID:: 200016679

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Select item 20001667718.

Gene expression profiling of Down Syndrome (DS)-AMKL and non-DS AMKL samples

(Submitter supplied) The goal of this study is to define a gene expression signature unique to DS-AMKL (acute megakaryoblastic leukemia or FAB M7 leukemia). A similar study was done previously, but using unfractionated patient leukemic samples. In this study, we sorted megakaryocytic leukemia blasts from patients and then compared their gene expression signatures to those from similarly sorted blasts from patients with non-DS AMKL. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
18 Samples

Download data: CEL

Series

Accession:: GSE16677

ID:: 200016677

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Select item 20001667619.

Rescue of murine Gata1s mutant M7 leukemic cells by full-length Gata1

(Submitter supplied) In this project, we studied a mouse model of human Down Syndrome (DS) megakaryocytic leukemia involving mutations in the GATA1 transcription factor (called GATA1s mutation). The model was generated through retroviral insertional mutagenesis in Gata1s mutant fetal liver progenitors. In this study, we analyzed the dependency of these leukemic cells on the Gata1s mutant protein. Here we report Gata1s mutant leukemic cells were dependent on this mutant protein. more...