Similar studies for GEO DataSets (Select 1678) - GEO DataSets

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Items: 10

Select item 16781.

Quercetin effect on hepatic cytochrome P-450 oxidoreductase null mutants

Analysis of cytochrome-P450 oxidoreductase (POR) null mutants at 24 hours following consumption of anti-carcinogenic flavonoid, quercetin. Results identify a diminished transcriptomic response in KO compared to WT in all tissues examined and provide insight into the bioactive nature of quercetin.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 4 tissue sets

Platform:: GPL339
Series:: GSE4262
48 Samples

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DataSet

Accession:: GDS1678

ID:: 1678

Select item 2000042622.

Transcriptional responses to quercetin in WT and POR-null mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1678
Platform:: GPL339
48 Samples

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Series

Accession:: GSE4262

ID:: 200004262

Select item 2000042593.

Liver transcriptional response to quercetin in WT and POR-null mice

(Submitter supplied) Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild type (WT) and POR-null (KO) mice, showing that hepatic P450 and reduced biliary secretion do not affect quercetin metabolism. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
12 Samples

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Series

Accession:: GSE4259

ID:: 200004259

Select item 2000042584.

Jejunum transcriptional response to quercetin in WT and POR-null mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
12 Samples

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Series

Accession:: GSE4258

ID:: 200004258

Select item 2000042575.

Ileum transcriptional response to quercetin in WT and POR-null mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
12 Samples

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Series

Accession:: GSE4257

ID:: 200004257

Select item 2000042566.

Colon transcriptional response to quercetin in WT and POR-null mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
12 Samples

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Series

Accession:: GSE4256

ID:: 200004256

Select item 2000014687.

Hepatic reductase null

(Submitter supplied) Microarray analysis to examine the relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (CPR) null mice. Keywords: ordered

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1093
Platform:: GPL81
4 Samples

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Series

Accession:: GSE1468

ID:: 200001468

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 10938.

NADH-cytochrome P450 reductase deletion effect on liver

Analysis of liver from male 3 month old hepatic NADH-cytochrome P450 reductase null mutants (POR). Results provide insight into the central role of POR and the P450 system in controlling hepatic homeostasis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL81
Series:: GSE1468
4 Samples

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DataSet

Accession:: GDS1093

ID:: 1093

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000391409.

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

(Submitter supplied) Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on hepatic lipid metabolism and detailed serum lipid profiles, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to measure quantitatively serum lipid profiles and whole genome microarray analysis was used to identify the responsible mechanisms in liver. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
36 Samples

Download data: TXT

Series

Accession:: GSE39140

ID:: 200039140

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005134310.

Quercetin decreases high-fat diet induced bodyweight gain and accumulation of hepatic and circulating lipids in mice.

(Submitter supplied) Dietary flavonoids are supposed to be protective against cardiovascular diseases (CVD). Elevated circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. We investigated the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabolism in mice with diet induced body weight gain and hepatic lipid accumulation. Adult male mice received a high-fat diet without or with supplementation of 0.33% (w/w) quercetin for 12 weeks. more...