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Links from GEO DataSets

Items: 10

1.
Full record GDS1678

Quercetin effect on hepatic cytochrome P-450 oxidoreductase null mutants

Analysis of cytochrome-P450 oxidoreductase (POR) null mutants at 24 hours following consumption of anti-carcinogenic flavonoid, quercetin. Results identify a diminished transcriptomic response in KO compared to WT in all tissues examined and provide insight into the bioactive nature of quercetin.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 4 tissue sets
Platform:
GPL339
Series:
GSE4262
48 Samples
Download data
DataSet
Accession:
GDS1678
ID:
1678
2.

Transcriptional responses to quercetin in WT and POR-null mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1678
Platform:
GPL339
48 Samples
Download data
Series
Accession:
GSE4262
ID:
200004262
3.

Liver transcriptional response to quercetin in WT and POR-null mice

(Submitter supplied) Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild type (WT) and POR-null (KO) mice, showing that hepatic P450 and reduced biliary secretion do not affect quercetin metabolism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
12 Samples
Download data
Series
Accession:
GSE4259
ID:
200004259
4.

Jejunum transcriptional response to quercetin in WT and POR-null mice

(Submitter supplied) Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild type (WT) and POR-null (KO) mice, showing that hepatic P450 and reduced biliary secretion do not affect quercetin metabolism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
12 Samples
Download data
Series
Accession:
GSE4258
ID:
200004258
5.

Ileum transcriptional response to quercetin in WT and POR-null mice

(Submitter supplied) Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild type (WT) and POR-null (KO) mice, showing that hepatic P450 and reduced biliary secretion do not affect quercetin metabolism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
12 Samples
Download data
Series
Accession:
GSE4257
ID:
200004257
6.

Colon transcriptional response to quercetin in WT and POR-null mice

(Submitter supplied) Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild type (WT) and POR-null (KO) mice, showing that hepatic P450 and reduced biliary secretion do not affect quercetin metabolism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
12 Samples
Download data
Series
Accession:
GSE4256
ID:
200004256
7.

Hepatic reductase null

(Submitter supplied) Microarray analysis to examine the relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (CPR) null mice. Keywords: ordered
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1093
Platform:
GPL81
4 Samples
Download data
Series
Accession:
GSE1468
ID:
200001468
8.
Full record GDS1093

NADH-cytochrome P450 reductase deletion effect on liver

Analysis of liver from male 3 month old hepatic NADH-cytochrome P450 reductase null mutants (POR). Results provide insight into the central role of POR and the P450 system in controlling hepatic homeostasis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL81
Series:
GSE1468
4 Samples
Download data
9.

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

(Submitter supplied) Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on hepatic lipid metabolism and detailed serum lipid profiles, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to measure quantitatively serum lipid profiles and whole genome microarray analysis was used to identify the responsible mechanisms in liver. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
36 Samples
Download data: TXT
Series
Accession:
GSE39140
ID:
200039140
10.

Quercetin decreases high-fat diet induced bodyweight gain and accumulation of hepatic and circulating lipids in mice.

(Submitter supplied) Dietary flavonoids are supposed to be protective against cardiovascular diseases (CVD). Elevated circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. We investigated the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabolism in mice with diet induced body weight gain and hepatic lipid accumulation. Adult male mice received a high-fat diet without or with supplementation of 0.33% (w/w) quercetin for 12 weeks. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
21 Samples
Download data: TXT
Series
Accession:
GSE51343
ID:
200051343
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