Similar studies for GEO DataSets (Select 1705) - GEO DataSets

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Items: 20

Select item 17051.

MyD88-deficient macrophage response to lipopolysaccharide and E. coli

Analysis of MyD88 null mutant macrophages treated with LPS or live E. coli. MyD88 transduces cell signaling events downstream of Toll-like receptors, a key component of host defense. Results suggest most of the host response to endotoxin or live bacteria is actually regulated independently of MyD88.

Organism:: Mus musculus

Type:: Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation sets

Platform:: GPL1226
Series:: GSE1405
16 Samples

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DataSet

Accession:: GDS1705

ID:: 1705

Select item 2000014052.

LPS-induced and E. coli-induced gene expression in wildtype and MyD88-/- mouse macrophages

(Submitter supplied) Comparison of gene expression in wildtype and MyD88-/- C57BL/6J mouse macrophages treated with 10 ng/mL LPS for 2 hours versus media treated control macrophages, and, wildtype and MyD88-/- C57BL/6J mouse macrophages treated with live E. coli bacteria (log phase; 1 bact per 1 macrophage) for 2 hours versus media treated control macrophages. Cells from 4 mice of each geneotype were used and each individual provided its own control. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS1705 GDS1706
Platform:: GPL1226
31 Samples

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Series

Accession:: GSE1405

ID:: 200001405

Select item 17063.

MyD88-deficient macrophage response to lipopolysaccharide and E. coli (dye swap)

Organism:: Mus musculus

Type:: Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation sets

Platform:: GPL1226
Series:: GSE1405
15 Samples

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DataSet

Accession:: GDS1706

ID:: 1706

Select item 2000010584.

Reduced atherosclerosis in MyD88 null mice

(Submitter supplied) This series represents a comparison of gene expression in mouse aorta from MyD88-/-, apoE-/- mice versus apoE-/- control mice fed a high fat diet for 8 weeks, causing atherosclerotic lesion development. 5 MyD88-/-, apoE-/- mice were compared to 5 apoE-/- control mice and dye swap replicated for a total of 10 replicate microarrays. Keywords = Mus musculus Keywords = aorta Keywords = atherosclerosis Keywords = MyD88 Keywords: other

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1006
10 Samples

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Series

Accession:: GSE1058

ID:: 200001058

Select item 2000086215.

LPS tolerance in macrophages

(Submitter supplied) Among the multiple mechanisms that control the intensity and duration of macrophage activation, the development of a state of refractoriness to a second stimulation in cells treated with LPS has long been recognized. Release of inhibitory cytokines and alterations in intracellular signaling pathways may be involved in the development of LPS tolerance. Although a number of molecules have been implicated, a detailed picture of the molecular changes in LPS tolerance is still missing. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE8621

ID:: 200008621

Select item 2000039916.

Listeria host responses

(Submitter supplied) This logical set encompases several 8hr timecourses (0,1,2,4,8 hrs) and their replicates. All correspond to treatments of bone marrow derived macrophages. Abstract: Innate and adaptive immunity depends critically on host recognition of pathogen-associated molecules. Toll-like receptors (TLRs) are key mediators of pathogen surveillance at the cell or phagocytic vacuole surface. However, mechanisms underlying recognition of pathogens in other cellular compartments remain unclear, and responses elicited by cytosolic challenge are poorly characterized. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL3329 GPL3328
85 Samples

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Series

Accession:: GSE3991

ID:: 200003991

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000477837.

Transcriptional profiling of macrophage plasticity following recovery from Lipopolysaccharide (LPS) tolerance

(Submitter supplied) To investigate the plasticity of Lipolysaccharide (LPS) tolerance, we employed microarray profiling to analyse the gene expression profile in macrophage. Four macrophage populations were induced; Untreated macrophages (Control group), Acute response to LPS (LPS activation group), LPS tolerance (T – Tolerant group) and recovered (R = recovered macrophage group) Using transcriptional analysis we demonstrate that recovery from LPS tolerance (R – Recovery), as defined by cytokine gene expression, is associated with a global change in the transcriptional profile of macrophage. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
12 Samples

Download data: TXT

Series

Accession:: GSE47783

ID:: 200047783

Select item 2000081048.

Primary macrophage response to L. monocytogenes and bacteria-derived ligands

(Submitter supplied) Transcriptional profiling of macrophages (of various genetic backgrounds) infected with L. monocytogenes or transfected with purified ligands Keywords: Timecourse, cell type comparison, bacteria strain comparison, drug comparison, ligand comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
81 Samples

Download data: GPR

Series

Accession:: GSE8104

ID:: 200008104

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000081039.

WT macrophage response to transfected bacterial ligands

(Submitter supplied) Transcriptional profiling of WT macrophages transfected with L. monocytogenes genomic DNA, synthetic MDP, or both Keywords: Ligand comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
8 Samples

Download data: GPR

Series

Accession:: GSE8103

ID:: 200008103

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000810210.

WT macrophage response to WT L. monocytogenes, with or without CAPE treatment

(Submitter supplied) Transcriptional profiling of WT macrophages infected with WT L. monocytogenes for 180 minutes, with or without CAPE treatment Keywords: Drug comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
8 Samples

Download data: GPR

Series

Accession:: GSE8102

ID:: 200008102

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000810111.

WT and irf3-/- macrophage response to WT L. monocytogenes

(Submitter supplied) Transcriptional profiling of WT and irf3-/- macrophages infected with WT L. monocytogenes for 180 minutes Keywords: Cell type comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
12 Samples

Download data: GPR

Series

Accession:: GSE8101

ID:: 200008101

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000810012.

WT and myd88-/- macrophage response to WT and hly- L. monocytogenes

(Submitter supplied) Transcriptional profiling of WT and myd88-/- macrophages infected with WT and hly- L. monocytogenes for 30, 60, 120, or 180 minutes Keywords: Timecourse, cell type comparison, bacteria strain comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
53 Samples

Download data: GPR

Series

Accession:: GSE8100

ID:: 200008100

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002154813.

Gene Expression Profiles of RAW264.7 Macrophages Stimulated with Two Commonly Used Preparations of LPS

(Submitter supplied) Background: Toll-like family of receptors recognizes pathogen-associated molecular patterns (PAMPs) from different organisms. TLR4 is the receptor for bacterial lipopolysaccharide (LPS), dsRNA viral mimic poly(I:C) binds to TLR3, and bacterial CpG DNA signals through TLR9. TLR4 signaling is mediated by adaptor molecules Myd88 and TRIF while TLR3 pathway involves only the TRIF adaptor and TLR9 signals solely through Myd88. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL891
46 Samples

Download data: TXT

Series

Accession:: GSE21548

ID:: 200021548

Select item 20000634614.

Differential repression of TLR responses by PPARg and LXRs

(Submitter supplied) Transrepression mediated by PPARg and LXRs agonists (GW7845 and GW3965) in primary macrophages stimulated with LPS or poly I:C. Thioglycollate-elicited macrophages were isolated from mice by peritoneal lavage 3 days following peritoneal injection of 2.5 ml 3% thioglycollate (DIFCO). Cells were plated in RPMI medium 1640 and 10% fetal bovine serum, washed after 5 h the medium was removed and cells were fed with fresh medium containing 0.5% fetal bovine serum. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1310
14 Samples

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Series

Accession:: GSE6346

ID:: 200006346

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010395815.

Transcript dynamics in classically and alternatively activated macrophages

(Submitter supplied) Using RNA-seq, we have reported that signaling crosstalk among IFN-γ and LPS is integrated at the level of transcriptome and have associated with TFs and TcoFs changes. In addition, we also argue that the transcriptional differences between BMDMs and RAW264.7 macrophage cell line as well as IL-4 and IL-13 on M2 macrophages activation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
25 Samples

Download data: TAB

Series

Accession:: GSE103958

ID:: 200103958

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002499516.

Dendritic cell response to hypoxia and poly I:C

(Submitter supplied) Investigation whether hypoxic stabilization of HIF-1alpha quantitatively or qualitatively modifies the gene expression pattern induced by poly I:C, a TLR ligand that does not induce normoxic HIF-1alpha stabilization on its own (non-HIF-1alpha-stabilizing TLR ligand). Keywords: Comparison of single and combined treatment

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL, TXT

Series

Accession:: GSE24995

ID:: 200024995

Select item 20002287317.

Ager (Rage) and Myd88 deletion in resected mouse livers

(Submitter supplied) The effect of resection of mouse livers on survival serve as a model for the effect of resection of human livers, which are performed for both the purposes of removing sick tissue and for transplanting healthy tissue. When less than 70% of a mouse liver is resected, the mouse usually lives. However, when more than 70% is resected, there is an increased probability that the mouse will die. We have found that deletion of Ager (Advanced Glycation End products receptor) (Rage) increases the chance of mouse survival relavtive to WT. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
19 Samples

Download data: CEL

Series

Accession:: GSE22873

ID:: 200022873

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004429218.

Gene Expression data from mouse bone marrow derived macrophages treated with different inflammatory stimuli

(Submitter supplied) The activation profiles of macrophages under different immune and inflammatory conditions have generated great interest. LPS, in particular, is a commonly used in vitro model of infection and inflammation studies in macrophages. We have used gene expression microarrays to define the effects of each of three variables; LPS dose, LPS vs. interferons beta and gamma, and genetic background on the transcriptional response of mouse bone marrow-derived macrophages Macrophages derived from the C57BL/6 strain of mouse were challenged with increasing doses of LPS over a 24 hour time-course (0.5ng/ml, 5ng/ml, or 50ng/ml LPS). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
64 Samples

Download data: CEL

Series

Accession:: GSE44292

ID:: 200044292

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001772119.

Dendritic cell stimulation: 5 ligands, 9 time points

(Submitter supplied) mouse primary BMDCs were stimulated with tlr ligands and gene expression changes were profiled on Affymetrix arrays

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8759
96 Samples

Download data: CEL

Series

Accession:: GSE17721

ID:: 200017721

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001506620.

Macrophage Response to LPS, poly(I:C) and CpG DNA Stimulation

(Submitter supplied) Molecular Pathways and Transcriptional Networks Involved in the Macrophage Response to LPS, poly(I:C) and CpG DNA Stimulation Background: Toll-like family of receptors recognizes pathogen-associated molecular patterns (PAMPs) from different organisms. TLR4 is the receptor for bacterial lipopolysaccharide (LPS), dsRNA viral mimic poly(I:C) binds to TLR3, and bacterial CpG DNA signals through TLR9. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6466
54 Samples

Download data: TXT

Series

Accession:: GSE15066

ID:: 200015066

PubMed Full text in PMC Similar studies Analyze with GEO2R

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