GEO DataSets

(Submitter supplied) previously published mouse data Pubmed IDS: 12754511, 12839964 Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL76 GPL75

56 Samples

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(Submitter supplied) Gene expression analysis on growing breast cancer cell lines. Keywords: cancer cell line profiles

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

19 Samples

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(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

55 Samples

Download data

(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

153 Samples

Download data

(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

158 Samples

Download data

(Submitter supplied) Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

111 Samples

Download data

(Submitter supplied) Identification of E2F1-regulated genes that modulate the transition from quiescence into DNA synthesis, or have roles in apoptosis, signal transduction, membrane biology, and transcription repression. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS46

Platform:

GPL75

4 Samples

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Identification of E2F1-regulated genes that modulate the transition from quiescence into DNA synthesis, or have roles in apoptosis, signal transduction, membrane biology, and transcription repression.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL75

Series:

GSE498

4 Samples

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(Submitter supplied) Comparison of control wild-type and Rb-/- prostate epithelial cell lines under untreated and serum-free conditions Keywords = prostate Keywords = epithelial Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS575

Platform:

GPL81

9 Samples

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Comparison of retinoblastoma-deficient (Rb-/-) and control wild type prostate epithelial cell lines maintained in RPMI-1640 medium supplemented with 5% fetal bovine serum, or without serum for 48 hours.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line, 2 growth protocol sets

Platform:

GPL81

Series:

GSE934

9 Samples

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(Submitter supplied) The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. As p107 and p130 also exert overlapping functions in epidermis, we have generated Rb(F19/F19)K14cre;Rbl2-/- (pRb-;p130-) mice to analyze possible functional redundancies between pRb and p130. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

10 Samples

Download data: CEL

(Submitter supplied) Advances in genomic signatures have begun to dissect breast cancer heterogeneity, and application of these signatures will allow the prediction of which pathways are important in tumor development. Here we used genomic signatures to predict involvement of specific E2F transcription factors in Myc-induced tumors. We genetically tested this prediction by interbreeding Myc transgenics with mice lacking various activator E2F alleles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4094

Platform:

GPL8321

80 Samples

Download data: CEL, CHP

Analysis of MMTV-Myc tumors generated in an E2F wild-type, E2F1 null, E2F2 null or E2F3 heterozygous background. E2Fs are Myc transcriptional activators shown to regulate proliferation and apoptosis. Results provide insight into role of E2Fs in Myc-induced breast cancer.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation sets

Platform:

GPL8321

Series:

GSE24594

80 Samples

Download data: CEL, CHP

(Submitter supplied) k-ras oncogene was transduced into the HPV16-E6E7 immortalized normal human pancreatic duct epithelial cell line (H6c7) to generate a stable K-ras oncogene-expressing cell line (H6c7-Kr). The gene expression profile of the H6c7-Kr cells was compared to that of H6c7 cells. We have excluded (subtracted) genes that were deregulated by transduction of the construct used for K-ras oncogene expression. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

2 Samples

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(Submitter supplied) Deregulated expression of the Myc transcription factor is a frequent causal mutation in human cancer. Thousands of putative Myc target genes have been identified in in vitro studies, indicating that Myc exerts highly pleiotropic effects within cells and tissues. However, the complexity and diversity of Myc gene targets has confounded attempts at identifying which of these genes are the critical targets mediating Myc-driven tumorigenesis in vivo. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2025

Platform:

GPL81

27 Samples

Download data: CEL

Analysis of transgenic pancreatic islet beta cells after activation of Myc for up to 24 hours or activation for 21 days followed by deactivation for up to 6 days. Results provide insight into the molecular basis of Myc-driven tumorigenesis in vivo.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 other, 9 protocol sets

Platform:

GPL81

Series:

GSE4356

27 Samples

Download data: CEL

(Submitter supplied) Overall study: Identification of PDGF-dependent patterns of gene expression in U87 glioblastoma cells. RNA was obtained from triplicate dishes of 5 different groups of U87 cells, each (total 15) analyzed with one U95 microarray chip. Three different comparisons were made: 1) Clone 3.1 (34580-34582) vs. clone 3.3 (34583-34585) vs. parent U87 (34592-34594). Purpose: demonstrate that the gene expression profiles between these 3 cell lines are not different, so they could be pooled as a single untreated group. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1730

Platform:

GPL8300

15 Samples

Download data: CEL, EXP

Analysis of U87 glioblastoma (GBM) cell clones overexpressing a dominant-negative form of platelet-derived growth factor (PDGF) A subunit to inactive the PDGF autocrine signaling loop. The autocrine PDGF loop is a hallmark of GBM. Results identify genes regulated by oncogenic PDGF signaling.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:

GPL8300

Series:

GSE1923

15 Samples

Download data: CEL, EXP

(Submitter supplied) The rationale underlying hyperthermia is the fact that temperatures over 42.5˚C are highly cytotoxic to tumor cells. On the other hand, although mild hyperthermia at a range from 39 to 41˚C alone did not induce cytotoxicity in tumor cells, mild hyperthermia is reported to show a synergism with radiotherapy and anti-cancer drugs. Here, the effects of mild hyperthermia (41˚C for 30 min) on the gene expression in human lymphoma U937 cells were investigated using by an Affymetrix GeneChip system. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3291

Platform:

GPL96

4 Samples

Download data: CEL, CHP

Analysis of myelomonocytic lymphoma U937 cells subjected to mild hyperthermia. Mild hyperthermia alone does not induce apoptosis but it does show a synergism with radiotherapy and anti-cancer drugs. Results provide insight into molecular mechanisms underlying cellular responses to mild hyperthermia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL96

Series:

GSE10043

4 Samples

Download data: CEL, CHP