Similar studies for GEO DataSets (Select 200004644) - GEO DataSets

Select item 2000046441.

The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs

(Submitter supplied) Gene expression profiling in animal models exposed to cigarette mainstream smoke (CS) shapes up as a promising tool for investigating the molecular mechanisms involved in the onset and development of CS-related disease and may aid in the identification of disease candidate genes. Here we report on differential gene expression in lungs of rats exposed for 2, 7, and 13 weeks to 300 and 600 µg total particulate matter (TPM)/l CS with sacrifice 2, 6, or 20 h after the last exposure. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2188
Platform:: GPL3607
18 Samples

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Series

Accession:: GSE4644

ID:: 200004644

Select item 2000045162.

Gene expression profiles in lung tissue of rats following exposure to mainstream cigarette smoke

(Submitter supplied) Expression data from rats exposed to cigarette smoke (CS) at three concentrations (sham, 300µgTPM/l and 600µgTPM/l) for 13 weeks (5d/week; 2hrs/day) after three different recovery times (2hrs, 6hrs and 20hrs after last treatment); lung tissue Keywords: recovery time course and dose dependency

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Datasets:: GDS2194 GDS2195
Platforms:: GPL341 GPL342
18 Samples

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Series

Accession:: GSE4516

ID:: 200004516

Select item 21953.

Lung response to cigarette smoke: dose response (RAE230B)

Analysis of lungs of animals exposed to 300 or 600 ug total particulate matter (TPM)/l of cigarette smoke (CS) for 13 weeks and allowed to recover 2, 6, or 20 hours after the last exposure. Results provide insight into mechanisms involved in the onset and development of CS-related diseases.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 3 dose, 3 protocol sets

Platform:: GPL342
Series:: GSE4516
9 Samples

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DataSet

Accession:: GDS2195

ID:: 2195

Select item 21944.

Lung response to cigarette smoke: dose response (RAE230A)

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 3 dose, 3 protocol sets

Platform:: GPL341
Series:: GSE4516
9 Samples

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DataSet

Accession:: GDS2194

ID:: 2194

Select item 21885.

Lung response to cigarette smoke: dose response and time course (PIQOR)

Analysis of lungs of animals exposed to 300 or 600 ug total particulate matter (TPM)/l of cigarette smoke (CS) for up to 13 weeks and allowed to recover 2, 6, or 20 hours after the last exposure. Results provide insight into mechanisms involved in the onset and development of CS-related diseases.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, log2 ratio, 2 dose, 3 protocol, 3 time sets

Platform:: GPL3607
Series:: GSE4644
18 Samples

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DataSet

Accession:: GDS2188

ID:: 2188

Select item 2000183446.

The Transcriptome of Nrf2-Deficient Mice in Cigarette Smoke-Induced Emphysematous Changes

(Submitter supplied) Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases. Because of its emerging central role in orchestrating the general cellular antioxidant response, the pathway leading to the activation of the transcription factor Nrf2 has received mounting attention over the past decade in investigations aimed at elucidating CS-induced patho-physiological mechanisms. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3622
Platform:: GPL1261
110 Samples

Download data: CEL

Series

Accession:: GSE18344

ID:: 200018344

Select item 36227.

Nrf2-deficient lung response to cigarette smoke: dose response and time course

Analysis of lungs from transcription factor Nrf2-deficient animals exposed to cigarette smoke (CS) at various doses and for various lengths of time with or without a subsequent recovery period. Results provide insight into the impact of Nrf2 in acute and subchronic smoking scenarios.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 4 dose, 2 genotype/variation, 3 protocol, 3 time sets

Platform:: GPL1261
Series:: GSE18344
110 Samples

Download data: CEL

DataSet

Accession:: GDS3622

ID:: 3622

Select item 2000155638.

Modifications of the Rat Airway Explant Transcriptome by Cigarette Smoke

(Submitter supplied) Although a number of animal model studies have addressed changes in gene expression in the parenchyma and their relationship to emphysema, much less is known about the pathogenesis of cigarette smoke-induced small airway remodeling. In this study, we exposed rat tracheal explants to whole smoke for 15 minutes, and then cultured the explants in air. The airway transcriptome was evaluated using RAE 230_2 GeneChips. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3746
Platform:: GPL1355
47 Samples

Download data: CEL

Series

Accession:: GSE15563

ID:: 200015563

Select item 37469.

Cigarette smoke effect on tracheal explants

Analysis of tracheal explants at 2hrs and 24hrs following brief exposure to whole smoke. Some of the explants were pretreated with dexamethasone prior to smoke exposure. Results provide insight into the molecular mechanisms underlying pathogenesis of cigarette smoke-induced small airway remodeling.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 4 stress, 2 time sets

Platform:: GPL1355
Series:: GSE15563
47 Samples

Download data: CEL

DataSet

Accession:: GDS3746

ID:: 3746

Select item 20000707910.

Chronic rat exposure to cigarette smoke

(Submitter supplied) Chronic obstructive pulmonary disease is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways which could be responsible for the damaging consequences of smoking. To do this, we employed recently described bioinformatic methods to analyze differences in global gene expression, which we then related to the pathological changes induced by cigarette smoke (CS). more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL85
209 Samples

Download data: CEL

Series

Accession:: GSE7079

ID:: 200007079

Select item 20001293011.

Induction of the IL-6/signal transducer and activator of transcription pathway in the lungs of mice exposed to tobacco

(Submitter supplied) We have examined the impact of subchronic levels of tobacoo smoke on murine lungs. We have used high density DNA microarray and analysed lung tissues from mice exposed to mainstream tobacco smoke (MTS). Our results reveal induction of inflammatory cytokine interleukin-6 (IL-6) and its antagonist suppressor of cytokine signalling (SOCS3) mRNA in smoking group. We also show that these changes are transient and are reversed completely after a period of cessation of smoking. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL2881
39 Samples

Download data: TXT

Series

Accession:: GSE12930

ID:: 200012930

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002354612.

Whole-genome gene expression profiles of non-tumorous human lung tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10379
1349 Samples

Download data: CEL

Series

Accession:: GSE23546

ID:: 200023546

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002354513.

Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).