Similar studies for GEO DataSets (Select 200005447) - GEO DataSets

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Items: 10

Select item 2000054471.

p53 family members in myogenic differentiation and rhabdomyosarcoma development

(Submitter supplied) The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function during myogenic differentiation. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2420
Platform:: GPL1261
6 Samples

Download data

Series

Accession:: GSE5447

ID:: 200005447

Select item 24202.

Myoblast differentiation and p53 family members

Analysis of mock and deltaNp73alpha-expressing C2C12 myoblasts 6 and 24 hours after shifting the cells to a differentiation medium. DeltaNp73alpha, a p73alpha isoform, functions as a transdominant inhibitor of other p53 family members, interfering with multiple developmental programs.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell line, 3 time sets

Platform:: GPL1261
Series:: GSE5447
6 Samples

Download data

DataSet

Accession:: GDS2420

ID:: 2420

Select item 2000091443.

Spontaneous SCC induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors in mouse stratified epithelia

(Submitter supplied) The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spontaneous tumor development, indicating that, contrary to pRb, p53 is the predominant tumor suppressor acting in mouse epidermis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
8 Samples

Download data: CEL

Series

Accession:: GSE9144

ID:: 200009144

Select item 2000076784.

miRNA34 expression in SW480 cells

(Submitter supplied) SW480 were stably transfected with an episomal plasmid expressing GFP and miRNA34 from a bidirectional doxycyclin regulatable promoter (Bornkamm et al Nucleic Acids Res. 2005 Sep 7;33(16)). Polyclonal cell lines were obtained by selection with Hygromycin at 350ug/ml for 10 days. The cell llnes identified as GFP only express GFP, whereas the cell lines identified as miRNA34a express both GFP and miRNA34 under doxycyclin control. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL, TXT, XLS

Series

Accession:: GSE7678

ID:: 200007678

Select item 2000684685.

caArray_notte-00422: Molecular Dissection of Colon Cancer

(Submitter supplied) RNA expression data was generated as part of a colon cancer study. Samples were obtained from patients, including primary colon cancer, polyps, metastases, and matched normal mucosa (obtained from the margins of the resection). The RNA was extracted from tissue samples obtained from resections and hybridized to Affymetrix HG-U133 arrays. RNA expression data was also obtained for a few cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
390 Samples

Download data: CEL, CHP

Series

Accession:: GSE68468

ID:: 200068468

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000065056.

Tumor suppression by Interferon regulatory factor-1 relies on down-regulation of cyclin D1

(Submitter supplied) Interferons have been ascribed to mediate antitumor effects. IRF-1 is a major target gene of interferons. It inhibits cell proliferation and oncogenic transformation. Here we show that 60% of all mRNAs deregulated by oncogenic transformation mediated by c-myc and H-ras are reverted to the expression levels of non-transformed cells by IRF-1. These include cell cycle regulating genes. Activation of IRF-1 decreases cyclin D1 expression and CDK4 kinase activity concomitant with dephosphorylation of pRb. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2752
Platform:: GPL81
6 Samples

Download data: CEL

Series

Accession:: GSE6505

ID:: 200006505

Select item 27527.

Interferon regulatory factor-1 effect on transformed cells

Analysis of myc/ras transformed cells expressing interferon regulatory factor-1 (IRF-1). IRF-1 mediates proliferation inhibition and reversion of the transformed phenotype of oncogenic cells. Results provide insight into the molecular alterations initiated by the action of IRF-1.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type, 2 protocol sets

Platform:: GPL81
Series:: GSE6505
6 Samples

Download data: CEL

DataSet

Accession:: GDS2752

ID:: 2752

Select item 2001146218.

Exon level expression analysis from rhabdomyosarcoma patient tumors.

(Submitter supplied) Rhabdomyosarcoma is a childhood tumor with features of aberrant muscle differentiation. We studied samples from 101 rhabdomyosarcoma patients to determine core gene expression signatures relevant in the disease.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
101 Samples

Download data: CEL

Series

Accession:: GSE114621

ID:: 200114621

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000297759.

Rhabdomyosarcomas in aging A/J mice

(Submitter supplied) Rhabdomyosarcomas (RSCs) are skeletal muscle neoplasms found in humans and domestic mammals. The A/J inbred strain developed a high frequency of RSC by 20 months of age while BALB/cJ and BALB/cByJ also develop RSC but less frequently. These neoplasms affected skeletal muscle surrounding either the axial or proximal appendicular skeleton and were characterized by pleomorphic cells with abundant eosinophilic cytoplasm, multiple nuclei, and cross striations that invaded locally. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5527
Platform:: GPL6481
12 Samples

Download data: TXT

Series

Accession:: GSE29775

ID:: 200029775

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 552710.

Rhabdomyosarcoma model

Analysis of rhabdomyosarcoma samples from A/J animals that are about 450 days old. A/J animals develop adult pleomorphic type rhabdomyosarcomas at a high frequency over 20 months of age. Results provide insight into the molecular pathogenesis of rhabdomyosarcoma.