GEO DataSets

(Submitter supplied) We construced combinations of genetic deletions to infer genetic interactions in genomic expression data. Keywords: combinatorial genetic perturbations

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platforms:

GPL90 GPL2622

90 Samples

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(Submitter supplied) Wild-type diploid cells were shifted from yeast-form growth in SHAD liquid (plentiful glucose and ammonium) to filamentous-form growth on SLAD agar (low ammonium). Samples of filamentous-form cells were collected hourly for 10 hours. Filamentous-form and yeast-form exponential-phase targets were co-hybridized. Keywords: time-course

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Dataset:

GDS608

Platform:

GPL507

10 Samples

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Temporal analysis of wild type diploid cells shifted from yeast-form growth in SHAD liquid (plentiful glucose and ammonium) to filamentous-form growth on SLAD agar (low ammonium). Filamentous-form cells collected hourly for 10 hours.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, log ratio, 10 time sets

Platform:

GPL507

Series:

GSE679

10 Samples

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(Submitter supplied) We identified a mutation that is a frameshift mutation in a mononucleotide run of eight consecutive T's in the coding region of the gene SSY1, which encodes a key component of a plasma-membrane sensor of extracellular amino acids.We introduced it into the S288c background and examined the effect on gene expression. Keywords: Total gene expression analysis

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL5092

6 Samples

Download data: GPR

(Submitter supplied) Spontaneous mutations were accumulated in haploid strains of yeast. Expression profiling was performed on four MA lines and the ancestor in a complete loop design. Keywords: Gene expression profiling

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL5092

10 Samples

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(Submitter supplied) Each strain was grown overnight then diluted in fresh rich media. After three hours strains were again rediluted into either rich media or rich media supplemented with copper sulfate. After another three hours cultures were sampled, cells lysed and flash frozen using liquid nitrogen. RNA was extrated using hot phenol-chloroform, reverse transcripbed using amino-allyle dUTP and labelled with either Cy3 or Cy5 flourescent dye. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL1007

60 Samples

Download data: JPG, TIFF

(Submitter supplied) Contains gene expression profiles of yeast single and double deletion mutants of gene-specific transcription factors. Genetic interactions were studied by comparing gene expression changes of double mutants with gene expression changes in the respective single mutants. Pairs of gene-specific transcription factors were chosen based on previous evidence for epistasis, including synthetic genetic interactions as well as common DNA binding.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL11232

287 Samples

Download data: TXT

(Submitter supplied) Expression analysis of BY4716(isogenic to S288c) and a wild isolate collected by R. Mortimer. Each strain was grown in culture 6 independent times and RNA from each culture was isolated. Each of these RNA samples was subjected to a dye-swap pair of arrays (except the "RM11" sample, which only got one array). All arrays used the same pool of reference BY4716 sample. In sample titles, "BY" alone signifies the reference sample and all other strings represent independent cultures. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Datasets:

GDS93 GDS94

Platform:

GPL118

23 Samples

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(Submitter supplied) Expression analysis of F1 haploid segregants from a cross between BY4716 (isogenic to S288c) and a wild isolate collected by R. Mortimer. Each segregant sample was subjected to a dye-swap pair of arrays. All arrays used the same pool of reference BY4716 sample. In sample titles, "BY" alone signifies the reference sample and all other strings represent segregants. All sample titles are of the form S1-S2. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Datasets:

GDS91 GDS92

Platform:

GPL118

80 Samples

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Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, log ratio, 2 strain sets

Platform:

GPL118

Series:

GSE38

11 Samples

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Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, log ratio, 2 strain sets

Platform:

GPL118

Series:

GSE38

12 Samples

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Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, log ratio, 7 other sets

Platform:

GPL118

Series:

GSE37

40 Samples

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Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, log ratio, 7 other sets

Platform:

GPL118

Series:

GSE37

40 Samples

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(Submitter supplied) We used a molecular barcoding approach to quantify the fitness of ~60,000 randomly mutated variants of the Saccharomyces cerevisiae U3 snoRNA (the data were further used to calculate a map of intragenic epistatic interactions within this RNA molecule, as descibed in Puchta et al. 2016)

Organism:

Saccharomyces cerevisiae; synthetic construct

Type:

Other

Platforms:

GPL19604 GPL17143 GPL21440

37 Samples

Download data: TXT

(Submitter supplied) Genomewide characterization of YJR141W role in mRNA polyadenylation.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13821

16 Samples

Download data: BEDGRAPH

(Submitter supplied) Microarray data to analyze differential biology underlying pheromone response and overall mating efficiency in a yeast population

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL9825

96 Samples

Download data: TXT

(Submitter supplied) An important goal in disease genetics and evolutionary biology is to understand how mutations combine together to alter phenotypes and fitness.  Non-additive genetic (epistatic) interactions between mutations occur extensively within and between genes, which makes accurate genetic prediction a difficult challenge.  Moreover, for unclear reasons, the interactions between mutations change quite extensively across conditions, cell types, and species, with important consequences for both evolution and precision medicine such as the exploitation of synthetic lethality in cancer. To better understand the plasticity of genetic interactions, we reduced the problem to a minimal system where we combined mutations within a single protein performing a single cellular function. more...

Organism:

synthetic construct

Type:

Other

Platform:

GPL19604

18 Samples

Download data: TXT