GEO DataSets

(Submitter supplied) To help elucidate mechanistic differences between lengthening and shortening muscle contractions we compared changes in gene expression within 24 h of an acute bout of each type of contraction in the quadriceps. Three healthy young men performed shortening contractions with one leg while the contralateral leg performed lengthening contractions. Biopsies were taken from both legs before exercise, 3, 6, and 24 h afterwards. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2740

Platform:

GPL246

24 Samples

Download data: CEL

Analysis of skeletal muscles at various time points up to 24 hours after acute bouts of either lengthening (LCs) or shortening contractions (SCs). Resistance training using LCs results in greater increases in muscle size than SCs. Results provide insight into the molecular basis of this difference.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 individual, 2 protocol, 4 time sets

Platform:

GPL246

Series:

GSE7286

24 Samples

Download data: CEL

(Submitter supplied) This study examined the effects of castration and testosterone replacement on global differential gene transcription in the gastrocnemius muscle (m.Gas) in young adult mice over 14-days.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

9 Samples

Download data: CEL

(Submitter supplied) Background: Muscle responses to exercise are complex, and potentially include acute responses to exercise-induced injury as well as longer-term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to better understand the temporal changes that occur after severe exercise. Methods: Dogs were randomly assigned to undertake in a 160 km run (n=9), or to remain at rest (n=4). more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL6800

13 Samples

Download data: TXT

(Submitter supplied) Mice were subjected to 50 eccentric contractions (EC) or 50 isometric contractions (IC) using a non-invasive model, and then sacrificed 48 hours later. RNA from the tibialis anterior of 4 animals were pooled and then split into two groups for hybridization onto two separate Affymetrix MGU74Av2 chips. Control samples were contralateral to the exercised legs, and were only subjected to enough contractions to measure isometric torque. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS394

Platform:

GPL81

6 Samples

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Tibialis anterior muscle eccentric contraction (EC) and isometric contraction (IC) comparison. Mice subjected to 50 EC or 50 IC using non-invasive model, and sacrificed 48 hours later.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol sets

Platform:

GPL81

Series:

GSE435

6 Samples

Download data

(Submitter supplied) To further understand molecular mechanisms underlying skeletal muscle hypertrophy, expression profiles of translationally and transcriptionally regulated genes were characterized following an acute bout of maximally activated eccentric contractions. Experiments demonstrated that translational mechanisms contribute to acute gene expression changes following high resistance contractions with two candidate mRNAs, basic fibroblast growth factor (bFGF) and elongation factor-1 alpha (EF1alpha), targeted to the heavier polysomal fractions after a bout of contractions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS278

Platform:

GPL85

36 Samples

Download data: CEL

Trancriptionally and translationally-regulated gene expression underlying skeletal muscle hypertrophy induced by acute maximally activated eccentric contractions. Total RNA or polysomal RNA examined at one and six hours post contraction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 specimen, 3 time sets

Platform:

GPL85

Series:

GSE467

36 Samples

Download data: CEL

(Submitter supplied) Following spinal cord injury, skeletal muscle loss is rapid. This severe atrophy is attributed to declines in protein synthesis and increases in protein breakdown. However, the signaling mechanisms controlling these changes are not well understood. Nine male patients and one female patient with spinal cord injury (SCI) (Mean ± SEM = 43.9 ± 6.7 yrs) were recruited for this study. Six patients were quadriplegics and four patients were paraplegics. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL, CHP

(Submitter supplied) Although short-term disuse does not result in measurable muscle atrophy, studies suggest that molecular changes associated with protein degradation may be initiated within days of the onset of a disuse stimulus. We examined the global gene expression patterns in sedentary men (n = 7, mean age ± S.D = 22.1 ± 3.7 yr) following 48h unloading (UL) via unilateral lower limb suspension and 24h reloading (RL). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3762

Platform:

GPL570

21 Samples

Download data: CEL, CHP

Analysis of left vastus lateralis muscle biopsies from 7 sedentary men following unloading (48 hr) via unilateral lower limb suspensionand and subsequent reloading (24 hr). Results provide insight into molecular events underlying the earliest stages of skeletal muscle disuse and reambulation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 7 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE21496

21 Samples

Download data: CEL, CHP

(Submitter supplied) The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exericse.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

28 Samples

Download data: CEL, CHP

(Submitter supplied) Skeletal muscle has been identified as a secretory organ. We hypothesized that IL-6, a cytokine secreted from skeletal muscle during exercise, could induce production of other secreted factors in skeletal muscle. Keywords: Human skeletal muscle time course response to IL-6 infusion

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3290

Platform:

GPL570

9 Samples

Download data: CEL

Analysis of interleukin-6 (IL-6) infused skeletal muscle (SKM) biopsies at time points up to 6hr. IL-6, a cytokine secreted from skeletal muscle during exercise, works in both an autocrine and paracrine manner. Results provide insight into IL-6-induced expression of other secreted factors in SKM.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 individual, 3 time sets

Platform:

GPL570

Series:

GSE10685

9 Samples

Download data: CEL

(Submitter supplied) Muscle development and growth is an economically important process in the pig.The neonatal period is another important stage for the pig when the most rapid gain occurring in skeletal muscle.Gene expresseion changes during fetal and postnatal skeletal muscle development that can be used to enhance pig production efficiency, as well as for comparative developmental biology using the pig as a model for other mammalian species. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

12 Samples

Download data: CEL

(Submitter supplied) Full title: Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. Unaccustomed eccentric exercise damages muscle tissue stimulating mechanisms of recovery and remodeling that may be affected by cellular protection by the sex hormone 17β-estradiol (E2). Using cDNA microarrays, we screened for differences in mRNA expression caused by E2 and eccentric exercise. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

64 Samples

Download data: TXT

(Submitter supplied) Several different mechanical signals have been proposed to control the extent and pattern of myocardial growth and remodeling, though this has largely been studied using in vitro model systems that are not representative of intact myocardium or in vivo models in which isolating the effects of individual candidate stimuli is exceedigly difficult. We used a unique tissue culture system that allows the simultaneous control of multiple mechanical inputs and other potentially confounding stimuli (e.g., hormonal). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, TXT

(Submitter supplied) Digital gene expression profiling was used to characterize the assembly of genes expressed in equine skeletal muscle and to identify the subset of genes that were differentially expressed following a ten month period of exercise training. The study cohort comprised 7 thoroughbred racehorses from a single training yard. Skeletal muscle biopsies were collected at rest from the gluteus medius at two time points: T1 (unconditioned), (9 +/- 0.5 months old) and T2 (conditioned) (20 +/- 0.7 months old). more...

Organism:

Equus caballus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10300

13 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL16417 GPL16791

56 Samples

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(Submitter supplied) Physical exercise triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic factors like DNA methylation participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induces dynamic DNA demethylation at gene promoters, but the contribution of the demethylation precursor hydroxymethylcytosine is unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

20 Samples

Download data: TXT