Similar studies for GEO DataSets (Select 200008003) - GEO DataSets

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Items: 20

Select item 2000080031.

(Submitter supplied) In order to investigate the role of CD34 antigen in haematopoietic commitment, we overexpressed the human CD34 cDNA in human CD34+ cells by retroviral gene transfer. Keywords: treatment comparison

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
3 Samples

Download data: CEL

Series

Accession:: GSE8003

ID:: 200008003

Select item 2000080402.

CD34 antigen role in haematopoietic commitment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
6 Samples

Download data: CEL

Series

Accession:: GSE8040

ID:: 200008040

Select item 2000080023.

CD34 gene silencing

(Submitter supplied) In order to investigate the role of CD34 antigen in haematopoietic commitment, we silenced the CD34 gene expression in CD34+ stem/progenitor cells using a siRNA approach. Keywords: treatment comparison

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
3 Samples

Download data: CEL

Series

Accession:: GSE8002

ID:: 200008002

Select item 2000046884.

Molecular phenotype of G-CSF- or pegylated G-CSF-mobilized CD34+ cells

(Submitter supplied) Peripheral blood stem and progenitor cells (PBSC) are widely used for autologous and allogeneic hematopoietic stem cell transplantation. PBSC can be mobilized into the peripheral blood using cytokines, cytotoxic chemotherapy or a combination of both. Granulocyte colony stimulating factor (G-CSF) has become the most commonly administered cytokine for PBSC mobilization because of its high potency and lack of serious toxicity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2321
Platform:: GPL201
16 Samples

Download data

Series

Accession:: GSE4688

ID:: 200004688

Select item 23215.

Polyethylene glycol-conjugated G-CSF mobilized CD34+ cells

Analysis of granulocyte colony stimulating factor (G-CSF) or polyethylene glycol-conjugated (pegylated) G-CSF mobilized CD34+ hematopoietic stem and progenitor cells from multiple myeloma patients undergoing chemotherapy. Pegylated G-CSF has a longer half-life than unconjugated G-CSF.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL201
Series:: GSE4688
16 Samples

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DataSet

Accession:: GDS2321

ID:: 2321

Select item 2000014936.

Hematopoietic stem cell subsets

(Submitter supplied) Hematopoietic stem cell (HSC) subsets based on the CD34 expression and/or lineage markers expression Keywords: parallel sample

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1095
Platform:: GPL8300
6 Samples

Download data

Series

Accession:: GSE1493

ID:: 200001493

Select item 10957.

Hematopoeitic stem cells of various types

Expression profiling of Lin-CD34-, Lin-CD34+, and Lin+CD34+ peripheral blood hematopoeitic stem cells (HSCs). Results provide insight into the molecular basis of the association of CD34 expression with self-renewal and lineage commitment in HSCs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 cell type sets

Platform:: GPL8300
Series:: GSE1493
6 Samples

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DataSet

Accession:: GDS1095

ID:: 1095

Select item 2000037888.

Lin-, CD38-, CD34+ Hematopoietic Stem Cells.

(Submitter supplied) Lin-, CD38-, CD34+ hematopoietic stem cells. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL97
6 Samples

Download data: CEL, EXP

Series

Accession:: GSE3788

ID:: 200003788

Select item 2000312839.

Expression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs)

(Submitter supplied) Histone deacetylase (HDAC) inhibitors are widely utilized in hematopoietic malignance therapy; nevertheless, little is currently known concerning their effects on normal myelopoiesis. In order to investigate a putative interference of HDAC inhibitors in myeloid commitment of hematopoietic stem/progenitor cells (HSPCs) we treated CD34+ cells with valproic acid (VPA). Moreover, we investigate changes in gene expression induced by VPA treatment on HSPCs, by means of microarray analysis in VPA treated and untreated (CTR) CD34+ cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE31283

ID:: 200031283

Select item 20000300310.

Gene expression profiling of CD34+ hematopoietic cells expanded in a collagen I matrix

(Submitter supplied) CD34+ hematopoietic stem/progenitor cells (HSC) reside in the bone marrow in close vicinity to the endosteal bone surface, surrounded by osteoblasts, stromal cells and various extracellular matrix molecules. We utilized a bioartificial matrix containing fibrillar collagen I, the major matrix component of bone, as scaffold for ex vivo expansion of HSCs. CD34+ HSCs were isolated from umbilical cord blood and cultivated within reconstituted collagen I fibrils in presence of FLT3-ligand, SCF and IL-3. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1401
Platform:: GPL96
6 Samples

Download data

Series

Accession:: GSE3003

ID:: 200003003

Select item 140111.

CD34+ hematopoietic cells expanded in artificial matrix of fibrillar collagen I

Analysis of CD34+ hematopoietic stem/progenitor cells (HSC) expanded for 7 days in an artificial matrix of fibrillar collagen I, the major matrix component of bone. Results provide insight into the limitations of ex vivo expansion to increase the number of transplantable HSCs from cord blood.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 growth protocol sets

Platform:: GPL96
Series:: GSE3003
6 Samples

Download data

DataSet

Accession:: GDS1401

ID:: 1401

Select item 20001604212.

Retroviral transduction of CD34+ cells with P190 and P210 BCR/ABL1 fusion genes

(Submitter supplied) Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage The P190 and P210 BCR/ABL1 fusion genes are mainly associated with different types of hematologic malignancies, but it is presently unclear whether they are functionally different following expression in primitive human hematopoietic cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5886
18 Samples

Download data: GPR

Series

Accession:: GSE16042

ID:: 200016042

Select item 20000465513.

Timecourse of in vitro erythroid differentiation of human adult-derived peripheral blood CD34+ cells

(Submitter supplied) computational analysis of transcriptomic information during erythroid development Keywords: erythroid differentiation

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2431
Platform:: GPL570
18 Samples

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Series

Accession:: GSE4655

ID:: 200004655

Select item 243114.

Erythroid differentiation in vitro: time course

Analysis of adult differentiating CD34+ hematopoietic progenitor cells at various time points up to 11 days of growth in serum-free medium containing erythropoietin, interleukin-3 and stem cell factor. Results provide insight into the molecular basis of erythropoiesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 6 time sets

Platform:: GPL570
Series:: GSE4655
18 Samples

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DataSet

Accession:: GDS2431

ID:: 2431

Select item 20000341015.

IM CD34+ progenitors cells

(Submitter supplied) IM CD34+ vs BM CD34+ cells Keywords: parallel sample

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2397
Platform:: GPL96
6 Samples

Download data

Series

Accession:: GSE3410

ID:: 200003410

Select item 239716.

Idiopathic myelofibrosis: hematopoietic CD34+ stem cells

Analysis of pooled hematopoietic CD34+ stem cells from peripheral blood of patients with idiopathic myelofibrosis (IM), a rare chronic myeloproliferative disorder. Results provide insight into the molecular pathogenesis of IM.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL96
Series:: GSE3410
6 Samples

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DataSet

Accession:: GDS2397

ID:: 2397

Select item 20006030117.

MYB/miR4863p/MAF/ axis in hematopoietic progenitor cell fate decision

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Other

Platforms:: GPL13667 GPL19066
46 Samples

Download data: CEL

Series

Accession:: GSE60301

ID:: 200060301

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006030018.

miRNA expression profile (miEP) of myb-silenced CD34+ HPCs

(Submitter supplied) The transcription factor cMyb plays a key role in human primary CD34+ hematopoietic progenitor cells (HPCs) lineage choice, by enhancing erythropoiesis at the expense of megakaryopoiesis. We previously demonstrated that cMyb affects erythroid versus megakaryocyte lineage decision in part by transactivating KLF1 and LMO2 expression. To further unravel the molecular mechanisms through which cmyb affects lineage fate decision, we profiled the miRNA and mRNA changes in myb-silenced CD34+ HPCs. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL19066
10 Samples

Download data: TXT

Series

Accession:: GSE60300

ID:: 200060300

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005326319.

Expression profiling of human CD34+ cells derived from mobilized peripheral blood samples after overexpression of MEIS1B or MEIS1D

(Submitter supplied) MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells (HSPC) and in mature megakaryocytes. In contrast to its role in leukemogenesis, the role of MEIS1 in normal hematopoiesis is largely unknown. We show that MEIS1 can direct human hematopoietic progenitors towards a megakaryocyte-erythroid progenitor (MEP) fate. Ectopoic expression of MEIS1 in CD34+ cells resulted in increased erythroid differentiation at the expense of granulocyte and monocyte (GM) differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
9 Samples

Download data: TXT

Series

Accession:: GSE53263

ID:: 200053263

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000439120.

Expression data from primitive and maturing hematopoietic stem cells

(Submitter supplied) Gene expression studies from hematopoietic stem cell (HSC) populations purified to variable degrees have defined a set of stemness genes. The present study describes the construction and comparative molecular analysis of l-phage cDNA libraries from highly purified primitive HSCs (PHSCs) which retained their long term repopulating activities (LTRAs), and from maturing HSCs (MHSCs) which were largely depleted of LTRAs. more...