Similar studies for GEO DataSets (Select 200008199) - GEO DataSets

Select item 2000081991.

E18.5 Estrogen-related Receptor gamma Knockout Mouse Heart

(Submitter supplied) 3 ventricles from E18.5 male mice were pooled for each array. Three arrays per genotype. Title: ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Post-Natal Heart Abstract: At birth the heart undergoes a critical metabolic switch to transition from a predominant dependence on carbohydrates during fetal life to a greater dependence on postnatal oxidative metabolism. This remains the principle metabolic state throughout life; although pathologic conditions such as heart failure and cardiac hypertrophy reactivate components of the fetal genetic program to increase carbohydrate utilization. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2811
Platform:: GPL1261
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE8199

ID:: 200008199

Select item 28112.

Analysis of hearts from fetuses lacking ERRgamma, a gene expressed at high levels in fetal and postnatal heart. Results provide insight into the role of ERRgamma in the heart’s metabolic switch from a dependence on carbohydrates during fetal life to a dependence on postnatal oxidative metabolism.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL1261
Series:: GSE8199
9 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2811

ID:: 2811

Select item 2001353473.

RNA-Seq transcriptome profiling of postnatal age 35 days or P35 ventricles of cardiac-specific estrogen-related receptor alpha and gamma (ERRa/g) knock down (KD) mouse generated by AAV-cTnT-Cre injection and its control AAV-Luc injection.

(Submitter supplied) Transcriptional regulatory circuits that drive cardiomyocyte maturation during the developmental process are poorly understood. Estrogen-related receptor alpha and gamma (ERRa/g) have been shown to be involved in all aspects of mitochondrial energy production. However, the function of ERR during the postnatal cardiac developmental process is unclear. To examine the role of (ERRa/g) during postnatal cardiac maturation, we generated inducible cardiac-specific ERRa/g knockdown (KD) mice with adeno-associated virus serotype 9 (AAV9) expressing Cre. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: XLSX

Series

Accession:: GSE135347

ID:: 200135347

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001137844.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL21103 GPL17021
22 Samples

Download data: BW

Series

Accession:: GSE113784

ID:: 200113784

PubMed Full text in PMC Similar studies

Select item 2001137615.

RNA-Seq transcriptome profiling of embryonic age 17.5 or E17.5 ventricles of cardiac specific-estrogen-related receptor alpha and gamma (ERRa/g) knock out (KO) mouse generated by Nkx2.5-Cre driver and its control wild type.

(Submitter supplied) Transcriptional regulatory circuits that drive cardiomyocyte maturation during the developmental process are poorly understood. Estrogen-related receptor alpha and gamma (ERRa/g) have been shown to be involved in all aspects of mitochondrial energy production. However, the function of ERR during the cardiac developmental process is not understood well. To examine the role of (ERRa/g), we generated cardiac-specific ERRa/g knockout (KO) mice and found that the KO mice died within 24 hours post-birth. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: XLSX

Series

Accession:: GSE113761

ID:: 200113761

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001137606.

Genome-wide estrogen-related receptor gamma (ERRg) occupancy in human iPS cell-derived cardiomyocytes (hiPSC-CMs)

(Submitter supplied) Estrogen-related receptor gamma (ERRg) has been shown to control gene expression involved in a broad range of mitochondrial energy metabolism including oxidative phosphorylation, TCA cycle, and fatty acid oxidation. However, ERRg direct targets were not identified in cardiomyocytes. With ERRg ChIP-seq, we found ERRg peaks on the promoter regions of mitochondrial energy metabolic genes as expected. Besides, ERRg extensively distributed the promoter regions of cardiac contractile, ion channels and Ca2+ handling protein genes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: BW

Series

Accession:: GSE113760

ID:: 200113760

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000094457.

Low and High Capacity Runners - Sedentary and Trained: Left Ventricle

(Submitter supplied) Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high- and low running capacity (HCR and LCR, respectively) over 16 generations. HCR were born with an athletic phenotype, whereas LCR exhibited features of the metabolic syndrome. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3131
Platform:: GPL1355
16 Samples

Download data: CEL

Series

Accession:: GSE9445

ID:: 200009445

Select item 31318.

Hearts from low and high capacity runners with and without exercise training

Analysis of hearts from low (LCRs) and high capacity runners (HCRs) with or without exercise training. Aerobic capacity is a strong predictor of cardiovascular mortality. Results provide insight into the molecular basis for the difference in inborn aerobic capacity in the LCRs and HCRs.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 protocol, 2 strain sets

Platform:: GPL1355
Series:: GSE9445
16 Samples

Download data: CEL

DataSet

Accession:: GDS3131

ID:: 3131

Select item 2000188969.

ERRγ Regulates Cardiac, Gastric and Renal Potassium Homeostasis

(Submitter supplied) Genomic analysis of expression in brain, kidney, stomach, liver, and salivary tissues of perinatal ERRγ null and wild type mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
30 Samples

Download data: CEL

Series

Accession:: GSE18896

ID:: 200018896

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010490710.

ERRγ coordinates a transcriptional program of mitochondrial and renal reabsorptive functions implicated in kidney disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data

Series

Accession:: GSE104907

ID:: 200104907

PubMed Full text in PMC Similar studies

Select item 20010490611.

ERRγ coordinates a transcriptional program of mitochondrial and renal reabsorptive functions implicated in kidney disease [RNA-seq]

(Submitter supplied) Here we show that estrogen-related receptor γ (ERRγ) is an essential transcriptional coordinator of both renal mitochondrial and reabsorptive functions. ERRγ is highly and specifically expressed in the RECs, and its expression correlates with kidney function in humans. We generated REC-ERRγ KO mice which developed severe renal mitochondrial and reabsorptive dysfunction and fluid-filled cysts. Transcriptome and cistrome analysis revealed that ERRγ directly regulates mitochondrial metabolism and renal reabsorption. more...