Similar studies for GEO DataSets (Select 200009632) - GEO DataSets

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Items: 20

Select item 2000096321.

Gene expression profiles of RAW264.7 macrophage cells treated with Paeony root-derived compounds

(Submitter supplied) Paeony root has long been used for its anti-inflammatory effects. In this study, the effects of albiflorin, paeoniflorin, and paeonol, compounds from paeony root, on gene expression profiles were examined in macrophages. The RAW264.7 macrophages were treated with LPS in the presence or absence of albiflorin, paeoniflorin, or paeonol. Global mRNA expression levels were detected by using an oligonucleotide microarray platform covering the mouse whole genome. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL2995
33 Samples

Download data: TXT

Series

Accession:: GSE9632

ID:: 200009632

Select item 2000943172.

Gene expression analysis of macrophage response to infection with Streptococcus oralis or to treatment with hydrogen peroxide

(Submitter supplied) We compared the gene expression patterns of macrophages infected with S. oralis wild type and SpxB KO, a strain that does not produce H2O2.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21810
8 Samples

Download data: TXT

Series

Accession:: GSE94317

ID:: 200094317

Select item 2000085153.

Identification of IL-1 and IL-6-responsive genes in human monocyte-derived macrophages

(Submitter supplied) Using whole-genome Affymetrix microarrays (HG-U133A), we characterized the transcriptome profile of cultured human macrophages stimulated for 4 h with interleukin 1 (IL-1) or interleukin 6 (IL-6). We found that, in distinction to liver cells, IL-1 is much more potent than IL-6 in modifying macrophage gene expression, although considerable heterogeneity in response of macrophages deriving from individual blood donors was observed. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3005
Platform:: GPL96
15 Samples

Download data: CEL

Series

Accession:: GSE8515

ID:: 200008515

Select item 30054.

Macrophage response to interleukins 1 and 6

Analysis of cultured monocyte-derived macrophages (MDM) stimulated with interleukin (IL) 1 or IL-6 for 4 hours. Cytokines IL-1 and IL-6 are not only produced by macrophages but also affect the cells in an autocrine manner. Results provide insight into IL-1 and IL-6 responsive genes in MDMs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent sets

Platform:: GPL96
Series:: GSE8515
15 Samples

Download data: CEL

DataSet

Accession:: GDS3005

ID:: 3005

Select item 2000146755.

Identification of Hedgehog Signaling and Novel Transcription Factors Involved in Regulation of Systemic Response to LPS

(Submitter supplied) Background: Our understanding of the role host genetic factors play in the initiation and severity of infections caused by Gram negative bacteria is incomplete. Methods: To identify novel regulators of the host response to lipopolysaccharide (LPS), 11 inbred murine strains were challenged with LPS systemically. RNA from lung, liver, and spleen tissue was profiled on oligonucleotide microarrays to determine if unique transcripts differentiate susceptible and resistant strains of mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6466
264 Samples

Download data: TXT

Series

Accession:: GSE14675

ID:: 200014675

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000685806.

caArray_bonda-00136: Molecular basis of age associated cytokine dysregulation in LPS stimulated macrophages

(Submitter supplied) Aged humans and rodents are susceptible to infection with Streptococcus pneumoniae bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines and increased production of interleukin (IL)-10 by macrophages (Mphi) from aged mice. To understand the molecular basis of cytokine dysregulation in aged mouse Mphi, a microarray analysis was performed on RNA from resting and lipopolysaccharide (LPS)-stimulated Mphi from aged and control mice using the Affymetrix Mouse Genome 430 2.0 gene chip. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE68580

ID:: 200068580

PubMed Similar studies

Select item 2000099887.

Innate immune repsonses to TREM-1 activation

(Submitter supplied) TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an immunoreceptor tyrosine-based activation motif (ITAM). TREM-1 activation by receptor cross-linking is pro-inflammatory, and can amplify cellular responses to Toll-like receptor (TLR) ligands such as bacterial lipopolysaccharide (LPS). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3499
Platform:: GPL570
62 Samples

Download data: CEL

Series

Accession:: GSE9988

ID:: 200009988

Select item 34998.

TREM-1 activation effect on monocytes in vitro

Analysis of cultured monocytes following TREM-1 activation by treatment with an antibody against TREM-1. TREM-1 is an immunoreceptor expressed on monocytes, macrophages, and neutrophils. Results provide insight into the cellular consequences of TREM-1 activation.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 6 agent, 11 individual sets

Platform:: GPL570
Series:: GSE9988
62 Samples

Download data: CEL

DataSet

Accession:: GDS3499

ID:: 3499

Select item 2000582209.

Expression data from primary term human decidual cells treated with interleukin-1-beta for 6 hours.

(Submitter supplied) Preterm birth is an important unsolved clinical problem. Despite advanced treatments, infants who survive prematurity remain at increased risk for permanent disabilities. In approximately one-third of cases, prematurity is related to infection and/or inflammation, which renders hostile the normally receptive intrauterine environment. Proinflammatory cytokines provoke up-regulation of genes that promote uterine contractions. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE58220

ID:: 200058220

Select item 20001976610.

Transcriptional responses of mouse bone marrow-derived macrophages (BMM) to lipopolysaccharide (LPS) - Illumina arrays

(Submitter supplied) These microarrays were performed for use in a genome-wide scan for LPS-regulated genes in mouse macrophages, in order to construct a list of LPS-regulated genes for detailed interrogation on custom microarrays (see GSE19490 for custom array analysis).

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4055
11 Samples

Download data: TXT

Series

Accession:: GSE19766

ID:: 200019766

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001976511.

Transcriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS) - Illumina arrays

(Submitter supplied) These microarrays were performed for use in a genome-wide scan for LPS-regulated genes in human monocyte-derived macrophages, in order to construct a list of LPS-regulated genes for detailed interrogation on custom microarrays (see GSE19482 for custom array analysis).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6102
10 Samples

Download data: TXT

Series

Accession:: GSE19765

ID:: 200019765

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001949212.

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

4 related Platforms
61 Samples

Download data: TXT

Series

Accession:: GSE19492

ID:: 200019492

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001949013.

Transcriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS)

(Submitter supplied) Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agonist, LPS. Using a custom platform permitting cross-species interrogation coupled with deep sequencing of mRNA 5’ ends, we identified extensive divergence in LPS-regulated orthologous gene expression between humans and mice (24% of orthologs, http://www.macgate.qfab.org). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL9802
24 Samples

Download data: TXT

Series

Accession:: GSE19490

ID:: 200019490

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001948214.

Transcriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9801
16 Samples

Download data: TXT

Series

Accession:: GSE19482

ID:: 200019482

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 10000980215.

Transcriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS)

(Submitter supplied) 60-mer spotted oligonucleotide probes. Protocol: See manufacturer's website (www.agilent.com).

Organism:: Mus musculus

2 Series
24 Samples

Download data

Platform

Accession:: GPL9802

ID:: 100009802

PubMed Full text in PMC Similar studies

Select item 10000980116.

Transcriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS)

(Submitter supplied) 60-mer spotted oligonucleotide probes. Protocol: See manufacturer's website (www.agilent.com).

Organism:: Homo sapiens

2 Series
16 Samples

Download data

Platform

Accession:: GPL9801

ID:: 100009801

PubMed Full text in PMC Similar studies

Select item 20003232517.

Expression and ChIP-seq analysis LPS stimulated THP-1 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL5175 GPL9052
26 Samples

Download data: BED, CEL

Series

Accession:: GSE32325

ID:: 200032325

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003232418.

ChIP-seq analysis LPS stimulated THP-1 cells

(Submitter supplied) Macrophages play a critical role in innate immunity, and the expression of early response genes orchestrate much of the initial response of the immune system. Macrophages undergo extensive transcriptional reprogramming in response to inflammatory stimuli such as Lipopolysaccharide (LPS). To identify gene transcription regulation patterns involved in early innate immune responses, we used two genome-wide approaches - gene expression profiling and chromatin immunoprecipitation-sequencing (ChIP-seq) analysis. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
18 Samples

Download data: BED

Series

Accession:: GSE32324

ID:: 200032324

PubMed Full text in PMC Similar studies

Select item 20003214119.

Expression analysis LPS stimulated THP-1 cells in four paired samples

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
8 Samples

Download data: CEL

Series

Accession:: GSE32141

ID:: 200032141

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000828620.

Gene expression profile during monocytes to macrophage differentiation

(Submitter supplied) Macrophages play a critical role in the pathogenesis of many diseases, including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Monocytes recruited into tissues from peripheral blood differentiate into macrophages. There is limited data concerning the global changes in the expression of genes during monocyte to macrophage, and how the patterns of change identify the mechanism contributing to differentiation or macrophage function. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3203
Platform:: GPL96
9 Samples

Download data: CEL

Series

Accession:: GSE8286

ID:: 200008286

PubMed Full text in PMC Similar studies Analyze with GEO2R

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