GEO DataSets

(Submitter supplied) To gain a better understanding of the factors necessary for successful CNS regeneration, a temporal analysis of the changes in gene expression in the eye caused by optic nerve injury was conducted. Dual color oligonucleotide microarrays were used to compare total RNA harvested from the eyes of sham-operated and optic nerve-injured fish at 3, 24, and 168 hours following surgery. Optic nerve injured fish are compared to sham-operated fish in order to eliminate gene expression due to non-neuronal damage and inflammatory response. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL9117

4 Samples

Download data: TXT

(Submitter supplied) Purpose: Investigate the molecular determinants of retinal regeneration in adult vertebrates by analyzing the gene expression profiles of control and post-lesion retina of adult zebrafish, a system that regenerates following injury. Methods: Gene expression profiles of zebrafish retina and brain were determined with DNA microarray, RT-PCR, and real-time quantitative PCR analyses. Damaged retinas and their corresponding controls were analyzed 2-5 days post-lesion (acute injury condition) or 14 d post-lesion (cell regeneration condition). more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS1404

Platform:

GPL1319

12 Samples

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Expression profiling of lesioned retina at various time points up to 14 days after injury. Results provide insight into the molecular mechanisms that enable the regeneration of injured retinas in adult anamniotes.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 4 disease state, 3 protocol, 6 time, 2 tissue sets

Platform:

GPL1319

Series:

GSE3303

12 Samples

Download data

(Submitter supplied) We used microarrays to analyse expression profiles of zebrafish retina after optic nerve crush to identify potential regulatory mechanisms that underpin central nerve regeneration

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14688

8 Samples

Download data: TXT

(Submitter supplied) retinal ganglion cells die after optic nerve injury, either crush or transection. The molecular causesunderlying this degeneration are largely unkwon the purpose of this job is to find which (if any) gene regulation triggers RGC death with the final goal of design neuroprotective protocols Keywords: time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3374

Platform:

GPL1355

35 Samples

Download data: CEL

Temporal analysis of retinas of animals following intraorbital optic nerve transection (IONT) or intraorbital nerve crush (IONC). Optic nerve injury, which is more severe with IONT than IONC, triggers retinal ganglion cell death. Results provide insight into the molecular basis of this degeneration.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 protocol, 7 time sets

Platform:

GPL1355

Series:

GSE9918

35 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

24 Samples

Download data: CEL

(Submitter supplied) Central nervous system (CNS) trauma and neurodegenerative disorders trigger a cascade of cellular and molecular events resulting in neuronal apoptosis and regenerative failure. The pathogenic mechanisms and gene expression changes associated with these detrimental events can be effectively studied using a rodent optic nerve crush (ONC) model. The purpose of this study was to use a mouse ONC model to: (a) evaluate changes in retina gene expression, (b) identify neurodegenerative pathogenic pathways and (c) discover potential new therapeutic targets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) Central nervous system (CNS) trauma and neurodegenerative disorders trigger a cascade of cellular and molecular events resulting in neuronal apoptosis and regenerative failure. The pathogenic mechanisms and gene expression changes associated with these detrimental events can be effectively studied using a rodent optic nerve crush (ONC) model. The purpose of this study was to use a mouse ONC model to: (a) evaluate changes in optic nerve (ON) gene expression, (b) identify neurodegenerative pathogenic pathways and (c) discover potential new therapeutic targets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) To obtain and analyze early retinal changes at molecular level at 24h after ipsilateral intraorbital nerve radiation injury by gamma knife surgery

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

6 Samples

Download data: CEL

(Submitter supplied) Ischemic cardiopathy is the leading cause of death in the world, for which efficient regenerative therapy is not currently available. In mammals, after a myocardial infarction episode, the damaged myocardium is replaced by scar tissue featuring collagen deposition and tissue remodelling with negligible cardiomyocyte proliferation. Zebrafish, in contrast, display an extensive regenerative capacity as they are able to restore completely lost cardiac tissue after partial ventricular amputation. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS3623

Platform:

GPL1319

15 Samples

Download data: CEL

Analysis of hearts of zebrafish 1 to 7 days following partial heart amputation. Unlike mammals, zebrafish hearts display an extensive regenerative capacity. Results provide insight into the molecular basis of this regenerative capacity.

Organism:

Danio rerio

Type:

Expression profiling by array, transformed count, 2 protocol, 5 time sets

Platform:

GPL1319

Series:

GSE17993

15 Samples

Download data: CEL

(Submitter supplied) It is well-established that neurons in the adult mammalian central nervous system are terminally differentiated and, if injured, will be unable to regenerate their connections. In contrast to mammals, zebrafish and other teleosts display a robust neuroregenerative response. Following optic nerve crush (ONX), retinal ganglion cells (RGC) regrow their axons to synapse with topographically correct targets in the optic tectum, such that vision is restored in ~21 days. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

12 Samples

Download data: CEL, CHP