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The HDAC inhibitor Givinostat modulates key hematopoietic genes in JAK2V617F cells, affecting proliferation, differentiation and apoptosis
PubMed Similar studies Analyze with GEO2R
Oncostatin M effects in IMR90 cells
Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis
PubMed Full text in PMC Similar studies
Next Generation Sequencing of long-term hematopoietic cells (LT-HSCs) with or without mutations in JAK2 and Ezh2
PubMed Full text in PMC Similar studies SRA Run Selector
Next Generation Sequencing of megakaryocyte-erythrocyte progenitor cells (MEPs) with or without mutations in JAK2 and Ezh2
Murine Ba/F3 Cells: Ba/F3 cells expressing wild type JAK2 (WT cells) vs. Ba/F3 cells expressing JAK2 V617F mutant (VF cells)
PubMed Full text in PMC Similar studies Analyze with GEO2R
The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.
Differential expression profiles of type I JAK inhibitor persistent vs. naïve MPN cells
PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector
RNA-seq data from VavCre;Jak2+/+; Cdk6+/+, VavCre;Jak2V617F; Cdk6+/+, VavCre;Jak2V617F; Cdk6-/-, VavCre; Jak2+/+; Cdk6-/- murine bone marrow LSK cells and VavCre; Jak2V617F; Cdk6+/+ Palbociclib treated murine bone marrow LSK cells
Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and JAK2-V617F expressing hematopoietic stem and progenitor subsets
Metabolic Alterations in JAK2 Mutant Hematopoietic Cells Represent Therapeutic Vulnerabilities for Myeloproliferative Neoplasms
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression (RNA-Seq)
Pbx1 expression is required for myeloproliferative neoplasm onset and maintenance
Splicing factor Ybx1 maintains persistent Jak2-mutated neoplasms via Mknk1-ERK-signaling persistent clones in Jak2-mutated neoplasms
PubMed Similar studies SRA Run Selector
RNA splicing factor Ybx1 maintains persistent Jak2-mutated neoplasms via Mknk1-ERK-signaling
Splicing factor Ybx1 mediates persistence of Jak2-mutated neoplasms
PRMT1-dependent histone arginine methylation regulates mature beta cell identity (ATAC-Seq)
PRMT1-dependent histone arginine methylation regulates mature beta cell identity (ChIP-Seq)
PRMT1-dependent histone arginine methylation regulates mature beta cell identity (RNA-Seq)
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