Similar studies for GEO DataSets (Select 200031294) - GEO DataSets

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Items: 20

Select item 2000312941.

Effect of p53 knowkdown on genome-wide map of AR-DNA binding

(Submitter supplied) We report that p53 knockdown changed AR-DNA binding across the genome. We found fewer AR-binding sites in the absence of p53.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL10999
2 Samples

Download data: BED

Series

Accession:: GSE31294

ID:: 200031294

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000491532.

Effect of FOXA1 overexpression in prostate cancer

(Submitter supplied) FOXA1 is a transcription factor which aids AR function in prostate. There is controversary over the effect of high FOXA1 level has on prostate cancer so we forced the overexpression in the LNCaP prostate cancer cell line.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4957
Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE49153

ID:: 200049153

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49573.

FOXA1 overexpression effect on prostate cancer cell line

Analysis of LNCaP prostate cancer cells overexpressing FOXA1. FOXA1 is a key member of the androgen receptor (AR) transcription factor complex. Results provide insight into the role of FOXA1 in prostate cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL10558
Series:: GSE49153
12 Samples

Download data

DataSet

Accession:: GDS4957

ID:: 4957

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000483084.

Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer

(Submitter supplied) Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LNCaP prostate cancer (PC) cell line, one overexpressing AR 2–3-fold and the other 4–5-fold compared with the control cells. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
13 Samples

Download data: BED

Series

Accession:: GSE48308

ID:: 200048308

PubMed Similar studies SRA Run Selector

Select item 2000550075.

Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

5 related Platforms
31 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE55007

ID:: 200055007

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000549916.

Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program [array]

(Submitter supplied) Previous studies have shown that FOXA1 defines prostatic AR binding events, the underlying mechanisms of which, however, are incompletely understood.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE54991

ID:: 200054991

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000479877.

FoxA1 inhibits androgen receptor expression and suppresses prostate cancer metastasis [DU145, ChIP-seq]

(Submitter supplied) FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore, the role of FoxA1 itself in prostate cancer has not been carefully examined. Thus, it is important to understand the role of FoxA1 in prostate cancer and how it interacts with AR signaling.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791
18 Samples

Download data: TXT

Series

Accession:: GSE47987

ID:: 200047987

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000373458.

FoxA1 inhibits androgen receptor expression and suppresses prostate cancer metastasis [LNCaP, ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL15456 GPL10999
9 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE37345

ID:: 200037345

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000560869.

PIAS1 is a target gene selective androgen receptor coregulator in prostate cancer cell chromatin

(Submitter supplied) To study the importance of PIAS1 (protein inhibitor of activated STAT1) for the androgen-regulated transcriptome of VCaP prostate cancer cells, we silenced its expression by RNAi. Transcriptome analyses revealed that a subset of the androgen-regulated genes is significantly influenced, either activated or repressed, by PIAS1 depletion. The depletion also exposed a completely new set of genes to androgen regulation, suggesting that PIAS1 can mask genes from androgen receptor (AR). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL9052
24 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE56086

ID:: 200056086

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003031610.

Genome-wide analysis of the effect of PIAS1 knockdown by siRNA on the androgen regulated gene programs

(Submitter supplied) Analysis of PIAS1 co-regulation in the androgen signaling pathways in prostate cancer cell line.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE30316

ID:: 200030316

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008386011.

Crosstalk between androgen and proinflammatory signaling activates a distinct transcription program in prostate cancer cells

(Submitter supplied) Crosstalk of androgen signaling induced with dihydrotestosterone (DHT) and proinflammatory signaling induced with tumor necrosis-factor alpha (TNFa) was analyzed in prostate cancer cells (LNCaP) by following chromatin binding of androgen receptor (AR), p65 (activating subunit of nuclear-factor kappa-B [NFkB]), FOXA1 and PIAS1+2 chromatin binding using ChIP-seq and transcriptional changes using GRO-seq.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platform:: GPL11154
46 Samples

Download data: BED, TDF

Series

Accession:: GSE83860

ID:: 200083860

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20002859612.

NKX3-1, a Novel Transcriptional Factor of AR, Promotes Prostate Cancer Cell Survival via RAB3B GTPase-mediated protein trafficking (mRNA)

(Submitter supplied) Androgen receptor (AR) orchestrates an intricate transcriptional regulatory network that governs prostate cancer initiation, development and progression. To understand this network in detail, we generated genome-wide maps of AR occupancy by ChIP-seq in LNCaP cells. We found NKX3-1, an androgen-dependent homeobox protein well-characterized for its role in prostate development and differentiation, being recruited to AR binding sites (ARBS) in response to androgen signaling. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6255
8 Samples

Download data: TXT

Series

Accession:: GSE28596

ID:: 200028596

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002826413.

NKX3-1, a Novel Transcriptional Factor of AR, Promotes Prostate Cancer Cell Survival via RAB3B GTPase-mediated protein trafficking

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
9 Samples

Download data: BED, TXT

Series

Accession:: GSE28264

ID:: 200028264

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005272514.

Next Generation Sequencing Facilitates Quantitative Analysis of effect of knockdown of GATA2 on AR binding sites

(Submitter supplied) Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare AR binding activity in LNCaP cells with and without knockdown of GATA2. Methods: LNCaP cells between passage number 32-34 were used for assay. Cells are transfected with GATA2 specific or nonspecific siRNA and ChIP was performed, the ChIP producted was further used to generate library with illumina ChIP-seq kit. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: WIG

Series

Accession:: GSE52725

ID:: 200052725

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003062415.

Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL6947 GPL10558 GPL9052
31 Samples

Download data: BED, SAM, TXT, WIG

Series

Accession:: GSE30624

ID:: 200030624

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003062316.

Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [ChIP_seq, DHS_seq]

(Submitter supplied) We report the dual role of FoxA1 in androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell line LNCaP-1F5 using ChIP-sequencing. Depletion of FoxA1 reprograms both androgen and glucocorticoid receptor recruitment and subsequent gene expression. The ChIP-seq has been performed using AR, FoxA1, GR, H3K4me2 antibodies. We have also mapped the DNaseI-hypersensitive sites (DHS) using deep sequencing.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
15 Samples

Download data: BED, SAM, TXT, WIG

Series

Accession:: GSE30623

ID:: 200030623

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003062217.

Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [Expression Array]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6947 GPL10558
16 Samples

Download data: TXT

Series

Accession:: GSE30622

ID:: 200030622

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007179718.

Genome-wide RNA-sequencing (RNA-seq) of benign and malignant prostate cell lines without and with androgen (R1881) stimulation.

(Submitter supplied) RNA-seq data were obtained from hTERT immortalized human prostate transit amplifying EP156T cells (+/- 10 nM R1881 for 48 hrs), progeny tumorigenic EPT3-M1 cells recovered from mouse metastatic tumor (+/- 10 nM R1881 for 48 hrs) and the prostate cancer cell lines LNCaP (+/- 10 nM R1881 for 48 hrs), VCaP (+/- 1 nM R1881 for 24 hrs) and 22Rv1 (+/- 1 nM R1881 for 24 hrs) (obtained from the American Type Culture Collection). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE71797

ID:: 200071797

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20001509119.

PC3 cells transfected with androgen receptor treated with various concentration of androgens

(Submitter supplied) We compared PC3 cells with or without harboring the wild-AR construct in the growth conditions of 1nM R1881, 10nM R1881 and ethanol (the solvent for R1881). The MOCK control is PC3 cells transfected with the empty vectors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
7 Samples

Download data: CEL

Series

Accession:: GSE15091

ID:: 200015091

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004005020.

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions

(Submitter supplied) The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR signalling. Treatment of advanced prostate cancer through medical or surgical castration leads to initial response and durable remission, but resistance inevitably develops. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL10999 GPL11154
35 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE40050

ID:: 200040050

PubMed Full text in PMC Similar studies SRA Run Selector

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