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Links from GEO DataSets

Items: 20

1.

SNP data from 12 childhood adrenocortical tumors from outside Brazil

(Submitter supplied) SNP array data from 12 childhood adrenocortical tumors (ACT) were used to identify recurrent chromosome rearrangements and candidate driver genes.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL8887 GPL6986
12 Samples
Download data: TXT
Series
Accession:
GSE35064
ID:
200035064
2.

SNP array profiling of childhood adrenocortical tumours reveals distinct pathways of tumourigenesis and highlights candidate driver genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL6985 GPL8887 GPL6986
31 Samples
Download data
Series
Accession:
GSE35066
ID:
200035066
3.

SNP data from 13 childhood adrenocortical tumours from Brazilian patients and 6 matched normal samples

(Submitter supplied) SNP array data from 13 Brazilian childhood adrenocortical tumors (ACTs) were analyzed to detect recurrent copy number changes and highlight potential candidate driver genes.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL6986 GPL6985
19 Samples
Download data
Series
Accession:
GSE24804
ID:
200024804
4.

Gene exrpression profiling of childhood adrenocortical tumors

(Submitter supplied) Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. Distinct patterns of gene expression, validated by quantitative real-time PCR and Western blot analysis, were identified that distinguish normal adrenal cortex from tumor. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
31 Samples
Download data: CEL
Series
Accession:
GSE75415
ID:
200075415
5.

Characterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.

(Submitter supplied) Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alterations.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3912
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE28476
ID:
200028476
6.
Full record GDS3912

Adrenocortical adenomas harboring β-catenin gene CTNNB1 mutations

Analysis of adrenocortical adenomas (AA) with β-catenin missense mutations and AAs with wild-type CTNNB1. Mutations of CTNNB1 are common in AA and adrenocortical carcinomas (ACC). Results provide insight into molecular mechanisms deregulated in adrenocortical tumors with CTNNB1 genetic alterations.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 genotype/variation, 3 other, 2 tissue sets
Platform:
GPL570
Series:
GSE28476
8 Samples
Download data: CEL
DataSet
Accession:
GDS3912
ID:
3912
7.

Gene expression profiling of pediatric adrenocortical tumors collected by the International Pediatric Adrenocortical Tumor Registry (IPACTR).

(Submitter supplied) We have previously observed that expression of HLA genes associate with histology of adrenocortical tumors (PMID 17234769). Here, we supplement that data with gene expression data on N additional tumors. This submission includes the data from the original study and N additional tumors.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
29 Samples
Download data: CEL
Series
Accession:
GSE76021
ID:
200076021
8.

Gene expression profiling of pediatric adrenocortical tumors of patients treated on the Children's Oncology Group XXX protocol.

(Submitter supplied) We have previously observed that expression of HLA genes associate with histology of adrenocortical tumors (PMID 17234769). Here, we used gene expression microarrays to associate the diagnostic tumor expression of these genes with outcome among 34 patients treated on the COG ARAR0332 protocol.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13158
34 Samples
Download data: CEL
Series
Accession:
GSE76019
ID:
200076019
9.

microRNA expression analysis of metastatic adrenocortical tumors

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is a rare, often-aggressive neoplasm of the adrenal cortex, with a 14.5-month median overall survival. We asked whether tumors from patients with advanced or metastatic ACC would offer clues as to putative genes that might have critical roles in disease progression or in more aggressive disease biology. Methods: We conducted comprehensive genomic and expression analyses, including microRNA profiling, of 33 ACCs and 6 normal adrenals. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL27982
39 Samples
Download data
Series
Accession:
GSE143385
ID:
200143385
10.

Gene expression analysis of metastatic adrenocortical tumors

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is a rare, often-aggressive neoplasm of the adrenal cortex, with a 14.5-month median overall survival. We asked whether tumors from patients with advanced or metastatic ACC would offer clues as to putative genes that might have critical roles in disease progression or in more aggressive disease biology. Methods: We conducted comprehensive genomic and expression analyses of 43 ACCs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16043
63 Samples
Download data: CEL, CHP
Series
Accession:
GSE143383
ID:
200143383
11.

Combined arrayCGH and SNP-loss of heterozygosity analysis in cervical cancer

(Submitter supplied) BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygosity (LOH). Currently, high throughput methods such as array comparative genomic hybridization (array CGH), single nucleotide polymorphism array (SNP array) and gene expression arrays are available to study genome-wide alterations. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array; Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL2641 GPL4012 GPL201
40 Samples
Download data: CEL, GPR
Series
Accession:
GSE8605
ID:
200008605
12.

SNP data from 76 adrenocortical carcinomas

(Submitter supplied) SNP array data from 76 adrenocortical carcinomas were used to detect recurrent copy number alterations.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL17913
76 Samples
Download data
Series
Accession:
GSE52296
ID:
200052296
13.

Integrated genomic analyses of adrenocortical tumors (SNP array, DNA methylation, mRNA and miRNA expression).

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by high throughput sequencing; SNP genotyping by SNP array; Methylation profiling by genome tiling array; Genome binding/occupancy profiling by array
6 related Platforms
324 Samples
Download data: CEL
Series
Accession:
GSE49280
ID:
200049280
14.

Micro-RNA sequencing from 78 adrenocortical carcinomas

(Submitter supplied) Micro-RNA sequencing of adrenocortical tumors and normal adrenal samples.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11154
78 Samples
Download data: TXT
Series
Accession:
GSE49279
ID:
200049279
15.

Expression profiling by array of 44 adrenocortical carcinomas

(Submitter supplied) Gene expression profiles of adrenocortical carcinomas were analyzed using Affymetrix Human Gene 2.0 ST Array to identify homogeneous molecular subgroups
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
44 Samples
Download data: CEL
Series
Accession:
GSE49278
ID:
200049278
16.

Genome-scale methylome profiling of adrenocortical carcinomas (ACC) and adenomas (ACA)

(Submitter supplied) Genome-scale DNA methylation was analyzed in a cohort of ACC and ACA to identify DNA methylation changes.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL8490
81 Samples
Download data: TXT
Series
Accession:
GSE49277
ID:
200049277
17.

SNP data from 45 adrenocortical carcinomas

(Submitter supplied) SNP array data from 45 adrenocortical carcinomas were used to detect recurrent copy number alterations.
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array
Platforms:
GPL8887 GPL13135
45 Samples
Download data
Series
Accession:
GSE49276
ID:
200049276
18.

Pathway implications of aberrant global methylation in adrenocortical cancer

(Submitter supplied) Context: Adrenocortical carcinomas (ACC) are a rare tumor type with a poor five-year survival rate and limited treatment options. Objective: Understanding of the molecular pathogenesis of this disease has been aided by genomic analyses highlighting alterations in TP53, WNT, and IGF signaling pathways. Further elucidation is needed to reveal therapeutically actionable targets in ACC. Design: In this study, global DNA methylation levels were assessed by the Infinium HumanMethylation450 BeadChip Array on 18 ACC tumors and 6 normal adrenal tissues. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
24 Samples
Download data: TXT
Series
Accession:
GSE77871
ID:
200077871
19.

Adrenocortical Carcinoma Gene Expression Profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL887 GPL570
63 Samples
Download data: CEL, TXT
Series
Accession:
GSE19776
ID:
200019776
20.

Adrenocortical Carcinoma Gene Expression Profiling [Agilent]

(Submitter supplied) Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen ACC tumors were profiled on both Affymetrix U133 Plus 2 or Agilent 22K Human Genome arrays; an additional six tumors were profiled on one or the other array. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
15 Samples
Download data: TXT
Series
Accession:
GSE19775
ID:
200019775
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