Similar studies for GEO DataSets (Select 200046159) - GEO DataSets

Select item 2000461591.

Segmental Allergen Challenge Regulates Gene Expression In Bronchoalveolar Lavage (BAL) Cells From Atopic and Mild Asthmatic Subjects

(Submitter supplied) Segmental allergen challenge increases the percentage of eosinophils in bronchoalveolar lavage (BAL) cells. Mepolizumab, an anti-IL-5 therapeutic antibody, decreases the number of eosinophils in bronchoalveolar lavages (BAL). The use of both procedures allows to define genes that are either expressed by eosinophils or dependent on eosinophil presence in the airways.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
8 Samples

Download data: CEL

Series

Accession:: GSE46159

ID:: 200046159

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000462382.

Sputum cell gene expression following allergen challenge

(Submitter supplied) Sputum cells collected before (visit 2) and after (visit 4) allergen challenge in asthma patients were isolated and RNA purified for analysis on gene expression arrays. Human subject recruitment part of NIH sponsored protocol as part of the Eosinophil Program Project Grant (PI: Dr. Nizar Jarjour)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
12 Samples

Download data: TXT

Series

Accession:: GSE46238

ID:: 200046238

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Select item 2001597823.

Increased IL-6 Trans-Signaling in the Airways After an Allergen Challenge

(Submitter supplied) The pro-inflammatory cytokine IL-6 is elevated in both blood and airways in asthma. IL-6 signaling is regulated by its receptor composed of two proteins, IL-6R and GP130, that are found in both membrane and soluble forms. The interaction of IL-6 with soluble IL-6R (sIL-6R) can trigger IL-6 trans-signaling in cells such as epithelial cells and fibroblasts, which express GP130, but do not produce sufficient IL-6R. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: XLSX

Series

Accession:: GSE159782

ID:: 200159782

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000577574.

Expression profiles of sorted murine lung Eosinophils following allergen challenge

(Submitter supplied) The eosinophil transcriptome analysis indicated a robust transcription change in eosinophils following allergen challenge in the lung.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5289
Platform:: GPL6246
7 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE57757

ID:: 200057757

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52895.

Lung eosinophil response to allergen challenge

Analysis of lung eosinophils of sensitized animals exposed intranasally to ovalbumin to induce eosinophilia. Eosinophilia, higher than normal eosinophil count, is a feature of allergic asthma. Results provide insight into the molecular response of eosinophils to allergen challenge.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL6246
Series:: GSE57757
7 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5289

ID:: 5289

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001827336.

Th17 signaling in asthma: relevance for psychopathology and neuroinflammation

(Submitter supplied) Asthma influences brain health both functionally (emotions) and structurally (neurodegeneration). Although airway inflammation is proposed to initiate afferent communications with the brain, the associated patterns of airway inflammation and gene-expression profiles are not established. Here, we investigate associations of gene expression in response to allergen challenge in the lung with functional magnetic resonance imaging (fMRI) in the brain.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
52 Samples

Download data: CSV

Series

Accession:: GSE182733

ID:: 200182733

Select item 2001304997.

Asthma IV

(Submitter supplied) Bronchial Epithelial Cells were isolated processed as described (Chu et al., 2002 and Zhao et al., 2011). The objective of the study was to identify differentially expressed genes between normal control (NC), mild-moderate asmathic (notSA) and severe asthmatic (SA) patients. For demographics data, contact Dr.Sally Wenzel (wenzelse@upmc.edu)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
154 Samples

Download data: TXT

Series

Accession:: GSE130499

ID:: 200130499

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Select item 2002468458.

Differential in vivo labeling with barcoded antibodies allows for simultaneous transcriptomic profiling of airway, lung tissue and intravascular immune cells

(Submitter supplied) We used single-cell RNA sequencing (scRNA-seq) paired with DNA-barcoded antibodies to see if it allows to distinguish immune cells in different anatomical compartments in the lung akin to flow cytometry. To do this, we infected Balb/c animals with non-typeable Haemophilus influenzae (NTHi) and administered barcoded anti-CD45 antibody intratracheally and intravenously to label airway and vascular immune cells respectively. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: CSV, MTX, TSV, TXT

Series

Accession:: GSE246845

ID:: 200246845

PubMed Full text in PMC Similar studies

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