Similar studies for GEO DataSets (Select 200049915) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000499151.

Transcriptomic analyses of TCDD treated zebrafish liver

(Submitter supplied) To fully understand molecular toxicity of TCDD in an in vivo animal model, adult zebrafish were exposed to TCDD at 10 nM for 96 h and the livers were sampled for RNA-sequencing based transcriptomic profiling. A total of 1,058 differently expressed genes were identified based on fold-change>2 and TPM (transcripts per million) >10. Among the top 20 up-regulated genes, 10 novel responsive genes were identified and verified by qRT-PCR analysis on independent samples. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10658
2 Samples

Download data: TXT

Series

Accession:: GSE49915

ID:: 200049915

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001061312.

TCDD exposure in control and slincR zebrafish morphants at 48 hpf

(Submitter supplied) Background: A structurally diverse group of chemicals, including polycyclic aromatic hydrocarbons (PAHs), can inappropriately activate the aryl hydrocarbon receptor (AHR) and lead to adverse health effects. In the zebrafish model, repression of sox9b has a causal role in several AHR-mediated toxic responses, including craniofacial cartilage malformations; however, the mechanism of sox9b repression remains unknown. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23274
16 Samples

Download data: TXT, XLSX

Series

Accession:: GSE106131

ID:: 200106131

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000101843.

2 or 3 Day Post Amputation Vehicle or TCDD Exposed

(Submitter supplied) Exposures to dioxin, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause a wide array of toxicities in vertebrates and is mostly considered to be mediated through the inappropriate activation of the aryl hydrocarbon receptor (Ahr) signaling pathway. Although transcriptional regulation by Ahr is widely studied, the molecular mechanisms responsible for the adverse outcomes after Ahr activation are largely unknown. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL1319
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE10184

ID:: 200010184

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001272174.

Establishing dose-strain specific transcriptomic changes in murine models of TCDD-induced toxicity

(Submitter supplied) Environmental contaminants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are known to cause a wide range of toxicities. The consequences of acute exposure to TCDD in rodents, and to a lesser degree in humans, can range from mild chloracne to terminal illness, such as cancer. The aryl hydrocarbon receptor (AHR) plays a critical role in mediating the toxic effects of TCDD. However, the underlying mechanism of differential sensitivities to TCDD across organisms remain poorly understood, however differences in the AHR are known to play a role. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL26227 GPL24557
34 Samples

Download data: CEL

Series

Accession:: GSE127217

ID:: 200127217

Select item 2000722705.

TCDD-induced hepatic transcriptomic responses in transgenic AHR-variant mice

(Submitter supplied) The aryl hydrocarbon receptor (AHR) mediates most of the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, TCDD toxicity phenotypes vary widely between species, strains and even between sexes within a strain. While the exact reasons for this variation remain unclear, it is thought to be related to differences in the structure of the AHR. Previous studies comparing the downstream effects of TCDD exposure between animals with different AHR isoforms have been confounded by the genetic differences between these model systems. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20837
60 Samples

Download data: CEL

Series

Accession:: GSE72270

ID:: 200072270

Select item 2000398096.

MicroRNA expression profiling after short-term exposure to TCDD in zebrafish embryos

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Betapolyomavirus macacae; Rattus norvegicus; JC polyomavirus; Betapolyomavirus hominis; Mus musculus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Danio rerio; Homo sapiens

Type:: Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL15720 GPL10658 GPL7724
36 Samples

Download data: TXT

Series

Accession:: GSE39809

ID:: 200039809

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000398087.

MicroRNA expression profiling after short-term exposure to TCDD in zebrafish embryos [miRNA-Seq data]

(Submitter supplied) Although many drugs and environmental chemicals are teratogenic, the mechanisms by which most toxicants disrupt embryonic development are not well understood. microRNAs (miRNAs), single-stranded RNA molecules of ~22 nt that regulate protein expression by inhibiting mRNA translation and promoting mRNA sequestration or degradation, are important regulators of a variety of cellular processes including embryonic development and cellular differentiation. more...

Organism:: Danio rerio

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL10658
12 Samples

Download data: TXT

Series

Accession:: GSE39808

ID:: 200039808

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000388398.

MicroRNA expression profiling after short-term exposure to TCDD in zebrafish embryos [agilent and exiqon array data]

Organism:: Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Betapolyomavirus macacae; Rattus norvegicus; Betapolyomavirus hominis; Mus musculus; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Danio rerio; Homo sapiens

Type:: Non-coding RNA profiling by array

Platforms:: GPL15720 GPL7724
24 Samples

Download data: TXT

Series

Accession:: GSE38839

ID:: 200038839

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000314119.

Inter-strain Heterogeneity in Responses to TCDD

(Submitter supplied) We profiled hepatic transcriptional responses of 6 strains of rats with varying sensitivity to a dioxin, TCDD, at 19 hours following exposure. The resistant rats exhibited significantly reduced transcriptional responses in comparison to the sensitive strains. We hypothesize that genes which show differential changes between the resistant and sensitive rats may potentially explain sensitivity.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL14122 GPL14123
56 Samples

Download data: CEL

Series

Accession:: GSE31411

ID:: 200031411

Select item 20001351310.

Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats

(Submitter supplied) The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR). The Han/Wistar (Kuopio) (H/W) strain shows exceptional resistance to many TCDD-induced toxicities; the LD50 of >9600 µg/kg for H/W rats is higher than for any other wild-type mammal known. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL9199
45 Samples

Download data: CEL, DAT

Series

Accession:: GSE13513

ID:: 200013513

Select item 20008095311.

Temporal comparison of transcriptomic alterations in human, mouse and rat primary B lymphocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

(Submitter supplied) RNA-Seq was used to analyze and compare temporal TCDD-induced gene expression changes in primary human, mouse and rat B cells. Most of the differentially expressed genes exibited species-specific expression. Cross-species comparison identified 28 orthologs commonly deregulated in all 3 species. The study provides new insight into mechanisms of TCDD-induced suppression of B cell effector function.

Organism:: Homo sapiens; Mus musculus; Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL16791 GPL18694
30 Samples

Download data: TXT

Series

Accession:: GSE80953

ID:: 200080953

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006103812.

Male and female mice show significant differences in hepatic transcriptomic response to TCDD

(Submitter supplied) 2,3,7,8–tetrachlorodibenzo-p-dixion (TCDD) is the most potent of the dioxin congeners, capable of causing a wide range of toxic effects across numerous animal models. Previous studies have demonstrated that males and females of the same species can display divergent sensitivity phenotypes to TCDD toxicities. Although it is now clear that most TCDD-induced toxic outcomes are mediated by the aryl hydrocarbon receptor (AHR), the mechanism of differential responses to TCDD exposure between sexes remains largely unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17153
40 Samples

Download data: CEL

Series

Accession:: GSE61038

ID:: 200061038

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001189313.

AHR Activation by TCDD Downregulates Sox9b Expression Producing Jaw Malformation in Zebrafish Embryos

(Submitter supplied) Exposure to environmental contaminants can disrupt normal development of the early vertebrate skeleton. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) impairs craniofacial skeletal development across many vertebrate species and its effects are especially prominent in early life stages of fish. TCDD activates the aryl hydrocarbon receptor (AHR), a transcription factor that mediates most if not all TCDD responses. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL1319
24 Samples

Download data: CEL

Series

Accession:: GSE11893

ID:: 200011893

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012251814.

Global gene expression profiling in HepaRG cells exposed to TCDD for 24 h

(Submitter supplied) Comparison of expression profiles detected inundifferemtitated HepaRG cells exposed to DMSO, TCDD for 24h. The aryl hydrocarbon receptor (AhR) activation has been shown to stimulate proliferation, promote apoptosis or alter differentiation of adult rat liver progenitors. We investigated the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated AhR activation on a human model of bipotent liver progenitors, undifferentiated HepaRG cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: IDAT, TXT

Series

Accession:: GSE122518

ID:: 200122518

Select item 20001830115.

Transcriptional profiling of the rat adipose tissue response to TCDD

(Submitter supplied) Rodents exposed to the environmental contaminant, TCDD, suffer from a number of acute and chronic toxicities, including lethality and a wasting syndrome. Hypothesizing that the wasting syndrome may be caused by changes in adipose tissue -- either in its hormonal regulation or in homeostatic effects -- we profiled the transcriptional response of rat white adipose to TCDD. We employed two separate rat strains: the Long-Evans strain is sensitive to TCDD toxicities while the Han/Wistar strain is over four orders of magnitude more resistant. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL9199
28 Samples

Download data: CEL, DAT

Series

Accession:: GSE18301

ID:: 200018301

Select item 20000281216.

Fetal mouse heart, TCDD dose-response series

(Submitter supplied) Pregnant C57Bl6N mice were treated with 0 (corn oil), 1.5, 3.0, or 6.0 ug/kg TCDD on gd14.5. Fetal hearts were collected on gd17.5. Hearts from each litter were pooled onto one chip. 4 replicates of each condition were run on affymetrix MG_U74Av2 chips, using standard affymetrix protocols and controls. Keywords: dose-response, 3 doses plus corn oil control, 4 replicates

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1302
Platform:: GPL81
20 Samples

Download data: CEL

Series

Accession:: GSE2812

ID:: 200002812

Select item 130217.

2,3,7,8-tetrachlorodibenzo-p-dioxin effect on cardiovascular development

Analysis of gestational day (GD) 17.5 fetal hearts isolated from pregnant C57BL/6Ns treated at GD 14.5 with up to 6.0 ug/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD, a cardiovascular teratogen, inhibits cardiomyocyte proliferation, a process that peaks between GD 14.5 to 17.5.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 4 dose sets

Platform:: GPL81
Series:: GSE2812
20 Samples

Download data: CEL

DataSet

Accession:: GDS1302

ID:: 1302

Select item 20001015718.

Altered gene expression in zebrafish embryos exposed to tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin

(Submitter supplied) Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis as well as to cardiovascular and neurodegenerative diseases. Developing animals may be especially sensitive to chemicals causing oxidative stress. To assess the response to chemicals at different stages of development, zebrafish (Danio rerio) embryos at 1, 2, 3, 4, 5, and 6 days post-fertilization (dpf) were exposed to 0.1% dimethyl sulfoxide (DMSO), 2 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or 10 uM tert-butylhydroquinone (tBHQ) for 6 hr. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL2878
12 Samples

Download data: TXT

Series

Accession:: GSE10157

ID:: 200010157

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005222919.

Knockdown of a zebrafish aryl hydrocarbon receptor repressor (ahrra) affects expression of genes related to photoreceptor development and hematopoiesis.

(Submitter supplied) The aryl hydrocarbon receptor repressor (AHRR) is a bHLH-PAS protein closely related to the aryl hydrocarbon receptor (AHR). AHRR is a transcriptional repressor of AHR and hypoxia-inducible factor (HIF) and is regulated by an AHR-dependent mechanism. Zebrafish possess two AHRR paralogs; AHRRa regulates constitutive AHR signaling during development, while AHRRb regulates polyaromatic hydrocarbon-induced gene expression. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL7302
6 Samples

Download data: TXT

Series

Accession:: GSE52229

ID:: 200052229

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004842720.

Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver

(Submitter supplied) In the present study, we employed the RNA sequencing platform to examine the molecular response of zebrafish liver to arsenic exposure and carry out detailed transcriptomic analyses for further understanding of molecular toxicity. We found that several important biological processes were perturbed by arsenic exposure, including oxidation reduction, translation, iron ion transport, cell redox and homeostasis, as well as related pathways in metabolism and diseases. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16034
2 Samples

Download data: TXT

Series

Accession:: GSE48427

ID:: 200048427

PubMed Full text in PMC Similar studies SRA Run Selector

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 20

Send to:

Supplemental Content

Find related data

Important Links

Recent activity