Similar studies for GEO DataSets (Select 200052617) - GEO DataSets

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Items: 20

Select item 2000526171.

Derivation of novel human ground state naïve pluripotent stem cells [ChIP-seq; RRBS-seq]

(Submitter supplied) Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2 and GSK3b signalling (termed 2i/LIF conditions). Hallmarks of naive pluripotency include driving Oct4 (also known as Pou5f1) transcription by its distal enhancer, retaining a pre-inactivation X chromosome state, global reduction in DNA methylation and in H3K27me3 repressive chromatin mark deposition on developmental regulatory gene promoters.Upon withdrawal of 2i/LIF, naïve mouse ES cells can drift towards a primed pluripotent state resembling that of the post-implantation epiblast. more...

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154 GPL17021
59 Samples

Download data: BED, TXT

Series

Accession:: GSE52617

ID:: 200052617

PubMed Similar studies SRA Run Selector

Select item 2000528242.

Derivation of novel human ground state naïve pluripotent stem cells.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

4 related Platforms
71 Samples

Download data: BED, CEL, TXT

Series

Accession:: GSE52824

ID:: 200052824

Select item 2000468723.

Derivation of novel human ground state naïve pluripotent stem cells [gene expression array]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL

Series

Accession:: GSE46872

ID:: 200046872

Select item 2000154874.

Breaking the epigenetic barrier during reversion of post-implantation epiblast cells

(Submitter supplied) Primitive ectoderm cells (PE) in blastocysts represent the foundation of the pluripotent state, which is lost progressively during development. For example, development of epiblast cells from PE in postimplantation embryos is accompanied by transcriptional and epigenetic changes, including DNA methylation and X inactivation (Refs); these changes alter the nature of epiblast cells fundamentally, affecting their responsiveness to signaling molecules, and constitute a robust boundary that prevents their reversion to a PE-like state. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL2995
12 Samples

Download data: TXT

Series

Accession:: GSE15487

ID:: 200015487

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000652145.

Global DNA CpG methylation profiling of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

(Submitter supplied) Global DNA CpG methylation profiling of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
24 Samples

Download data: TXT

Series

Accession:: GSE65214

ID:: 200065214

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000652116.

Global gene expression analysis of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

(Submitter supplied) Global gene expression analysis of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
24 Samples

Download data: TXT

Series

Accession:: GSE65211

ID:: 200065211

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000444307.

Comprehensive microarray analysis of reprogramming fidelity in a library of non-integrated induced pluripotent stem cell lines prepared with various derivation methods

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

4 related Platforms
207 Samples

Download data

Series

Accession:: GSE44430

ID:: 200044430

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000444278.

Global gene expression analysis of donor cells, low passage episomal stromal and non-stromal primed myeloid iPSC, and hESC

(Submitter supplied) Global gene expression analysis of (a) human embryonic stem cells, (b) low passage episomal stromal-primed iPSC derived from growth-factor activated CD34+ myeloid progenitors from cord blood or GCSF mobilized peripheral blood, and (d) samples of donor fibroblasts or myeloid progenitors

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
29 Samples

Download data: TXT

Series

Accession:: GSE44427

ID:: 200044427

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000444259.

Global gene expression analysis of human embryonic stem cells, adult fibroblasts, and CD34+ cord blood (CB) cells before, during, and after generation of stromal primed and non-stromal primed episomal induction of pluripotency

(Submitter supplied) Global gene expression analysis of (a) human embryonic stem cells, (b) adult fibroblasts with and without nucleofection of SOKM, (c) CD34+ cord blood cells at various time points during induction of pluripotency with SOKM, with or without co-culture with bone marrow stromal cells (BMSC), and (d) resulting stromal primed and non-stromal primed cord blood CD34+ myeloid iPSC

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
46 Samples

Download data: TXT

Series

Accession:: GSE44425

ID:: 200044425

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004442410.

Global CpG Methylation profiling of donor cells, induced pluripotent stem cells, and human embryonic stem cells

(Submitter supplied) Global CpG methylation profiling using Illumina 27k Infinium platform of (a) human embryonic stem cells, (b) low passage episomal stromal-primed myeloid iPSC, (c) intermediate passage fibroblast iPSC, and (d) samples of corresponding donor cells.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
43 Samples

Download data: TXT

Series

Accession:: GSE44424

ID:: 200044424

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004442111.

Global gene expression analysis of donor cells, low passage episomal stromal-primed myeloid iPSC, and intermediate passage fibroblast iPSC.

(Submitter supplied) Global gene expression analysis of (a) human embryonic stem cells, (b) low passage episomal stromal-primed myeloid iPSC, (c) intermediate passage fibroblast iPSC, and (d) samples of corresponding donor cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16700
41 Samples

Download data: TXT

Series

Accession:: GSE44421

ID:: 200044421

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003782212.

The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL6246 GPL13112
34 Samples

Download data: BED, CEL

Series

Accession:: GSE37822

ID:: 200037822

Select item 20003782113.

The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [ChIP-Seq]

(Submitter supplied) Pluripotency can be induced in somatic cells by ectopic expression of defined transcription factors, however the identity of epigenetic regulators driving the progression of cellular reprogramming requires further investigation. Here we uncover a non-redundant role for the JmjC-domain-containing protein histone H3 methylated Lys 27 (H3K27) demethylase Utx, as a critical regulator for the induction, but not for the maintenance, of primed and naïve pluripotency in mice and in humans. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
27 Samples

Download data: BED

Series

Accession:: GSE37821

ID:: 200037821

PubMed Similar studies SRA Run Selector

Select item 20003577514.

The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [Affymetrix gene expression]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
7 Samples

Download data: CEL

Series

Accession:: GSE35775

ID:: 200035775

Select item 20005852015.

Comparative FAIRE-seq analysis reveals distinguishing features of the chromatin structure of ground state- and primed pluripotent cells

(Submitter supplied) We utilized FAIRE-seq to identify accesible chromatin in mouse embryonic-, epiblast-, and neural- stem cells in addition to mouse embryonic fibroblasts. Analysis of these data sets reveal cell type specific chromatin signatures that differentiate naïve and primed pluripotency. Functional analysis of type-specific peaks revealed cell-type specific enhancers.