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Links from GEO DataSets

Items: 20

1.

Nkx2.2, Nkx6.1, Olig2, and Gli3 genomic binding regions and overexpression in neural progenitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL13112 GPL9250
28 Samples
Download data: BED
Series
Accession:
GSE65462
ID:
200065462
2.

mRNAseq analysis of Nkx2.2, Nkx6.1, and Olig2 overexpression in neural progenitors

(Submitter supplied) Nkx2.2, Nkx6.1, and Olig2 repressors were overexpressed, singly or in combination, in in vitro-derived mouse neural progenitors to identify thier repression targets
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
15 Samples
Download data: XLSX
Series
Accession:
GSE65457
ID:
200065457
3.

Nkx2.2, Nkx6.1, Olig2, and Gli3 genomic binding regions in neural progenitors [ChIP-Seq]

(Submitter supplied) Nkx2.2, Nkx6.1, and Olig2 are transcriptional repressors regulating somatic motor neuron and interneuron subtypes in neural progenitors. The purpose of this study was to identify their target genes and to elucidate their gene regulatory mechanisms, including their relationship to Sonic Hedgehog/Gli pathway.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL9250 GPL19057
13 Samples
Download data: BED, TXT
Series
Accession:
GSE61673
ID:
200061673
4.

Repression by PRDM13 is critical for generating precise neuronal identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data: BW
Series
Accession:
GSE90938
ID:
200090938
5.

Repression by PRDM13 is critical for generating precise neuronal identity (RNA-Seq)

(Submitter supplied) The mechanisms that activate some genes while silencing others are critical to ensure precision in lineage specification as multipotent progenitors become restricted in cell fate. During neurodevelopment, these mechanisms are required to generate the wide variety of neuronal subtypes found in the nervous system. Here we report interactions between basic helix-loop-helix (bHLH) transcriptional activators and the transcriptional repressor PRDM13 that are critical for these processes during specification of dorsal spinal cord neurons. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE90937
ID:
200090937
6.

Repression by PRDM13 is critical for generating precise neuronal identity (ChIP-Seq)

(Submitter supplied) The mechanisms that activate some genes while silencing others are critical to ensure precision in lineage specification as multipotent progenitors become restricted in cell fate. During neurodevelopment, these mechanisms are required to generate the wide variety of neuronal subtypes found in the nervous system. Here we report interactions between basic helix-loop-helix (bHLH) transcriptional activators and the transcriptional repressor PRDM13 that are critical for these processes during specification of dorsal spinal cord neurons. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: BW
Series
Accession:
GSE90936
ID:
200090936
7.

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
70 Samples
Download data: BW
Series
Accession:
GSE254693
ID:
200254693
8.

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [CUT&RUN 22]

(Submitter supplied) During development neural stem cells (NSCs) in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, followed by production of cortical macroglia and inhibitory neurons that migrate to the olfactory bulb (OB). Understanding the mechanisms for this lineage switch is fundamental for unraveling how proper numbers of diverse neuronal and glial cell types are controlled. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
28 Samples
Download data: BW
Series
Accession:
GSE254692
ID:
200254692
9.

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [CUT&RUN]

(Submitter supplied) During development neural stem cells (NSCs) in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, followed by production of cortical macroglia and inhibitory neurons that migrate to the olfactory bulb (OB). Understanding the mechanisms for this lineage switch is fundamental for unraveling how proper numbers of diverse neuronal and glial cell types are controlled. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
24 Samples
Download data: BIGBED
Series
Accession:
GSE254691
ID:
200254691
10.

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [ChIP-seq]

(Submitter supplied) During development neural stem cells (NSCs) in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, followed by production of cortical macroglia and inhibitory neurons that migrate to the olfactory bulb (OB). Understanding the mechanisms for this lineage switch is fundamental for unraveling how proper numbers of diverse neuronal and glial cell types are controlled. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
6 Samples
Download data: BED
Series
Accession:
GSE254690
ID:
200254690
11.

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [ATAC-seq]

(Submitter supplied) During development neural stem cells (NSCs) in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, followed by production of cortical macroglia and inhibitory neurons that migrate to the olfactory bulb (OB). Understanding the mechanisms for this lineage switch is fundamental for unraveling how proper numbers of diverse neuronal and glial cell types are controlled. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: BED
Series
Accession:
GSE254689
ID:
200254689
12.

cis-Regulation of Shh-directed neural pattering

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
4 related Platforms
16 Samples
Download data: BED, CEL, TSV
Series
Accession:
GSE42594
ID:
200042594
13.

Transcriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors

(Submitter supplied) The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE42565
ID:
200042565
14.

ChIP-seq analysis of Gli1 and Sox2 input to neural progenitor program and integration with actve histone marks

(Submitter supplied) In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentration-dependent induction of six different cell populations mediated through Gli transcriptional regulators. Elsewhere in the embryo, Shh/Gli responses invoke different tissue appropriate regulatory programs. To elucidate Shh/Gli regulation of neural fate sepcification, we performed Gli1 ChIP-Seq analysis. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL9185 GPL13112
10 Samples
Download data: BED, TSV
Series
Accession:
GSE42132
ID:
200042132
15.

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21103 GPL17021 GPL7202
28 Samples
Download data: BW, TXT
Series
Accession:
GSE85705
ID:
200085705
16.

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons (ChIP-Seq)

(Submitter supplied) The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors (TFs), regulatory elements (REs), and chromatin are thought to precisely regulate gene expression. In the medial ganglionic eminence (MGE), the NKX2-1 TF controls regional identity and, with LHX6, is necessary to specify pallidal projection neurons and forebrain interneurons. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21103 GPL17021
20 Samples
Download data: BW, TXT
Series
Accession:
GSE85704
ID:
200085704
17.

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons (microarray)

(Submitter supplied) The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors (TFs), regulatory elements (REs), and chromatin are thought to precisely regulate gene expression. In the medial ganglionic eminence (MGE), the NKX2-1 TF controls regional identity and, with LHX6, is necessary to specify pallidal projection neurons and forebrain interneurons. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
8 Samples
Download data: TXT, XLS
Series
Accession:
GSE85703
ID:
200085703
18.

Single cell RNA-seq analysis of pMN neural progenitors from zebrafish [Reanalysis of GSE155988 data set]

(Submitter supplied) The goal of this study was to identify distinct cell populations that arise from ventral spinal cord pMN progenitors. To do so, we sorted fluorescently marked pMN cells obtained from Tg(olig2:EGFP) zebrafish embryos at 24, 36 and 48 hours post fertilization and performed 10X Chromium single cell RNA-seq.
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24995
3 Samples
Download data: CSV, RDS
Series
Accession:
GSE173350
ID:
200173350
19.

Transcription Factor Network Specifying Inhibitory versus Excitatory Neurons in the Dorsal Spinal Cord

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL11002 GPL9185
13 Samples
Download data: BEDGRAPH
Series
Accession:
GSE55841
ID:
200055841
20.

Transcription Factor Network Specifying Inhibitory versus Excitatory Neurons in the Dorsal Spinal Cord [ChIP-Seq]

(Submitter supplied) The proper balance of excitatory and inhibitory neurons is crucial to normal processing of somatosensory information in the dorsal spinal cord. Two neural basic helix-loop-helix transcription factors, Ascl1 and Ptf1a, are essential for generating the correct number and sub-type of neurons in multiple regions of the nervous system.   In the dorsal spinal cord, Ascl1 and Ptf1a have contrasting functions in specifying inhibitory versus excitatory neurons. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL9185
6 Samples
Download data: BEDGRAPH
Series
Accession:
GSE55840
ID:
200055840
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