Similar studies for GEO DataSets (Select 200065811) - GEO DataSets

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Items: 20

Select item 2000658111.

miRNA profile of THP-1 macrophage infected with different MTB strains

(Submitter supplied) We examined the microRNA profiles of THP-1 macrophages upon the MTB infection of (1) Beijing/W and non-Beijing/W clinical strains, and (2) susceptible and multidrug-resistant (MDR-) MTB strains.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19763
14 Samples

Download data: TXT

Series

Accession:: GSE65811

ID:: 200065811

PubMed Full text in PMC Similar studies

Select item 2000658102.

miRNA profile of macrophage from different TB patients

(Submitter supplied) the microRNA profiles of the host macrophages were studied by microarray in a small cohort with active MTB disease, latent infection (LTBI), and from healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19763
10 Samples

Download data: TXT

Series

Accession:: GSE65810

ID:: 200065810

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Select item 2000546303.

Identification of latent tuberculosis infection-related microRNAs in human U937 macrophages expressing Mycobacterium tuberculosis Hsp16.3

(Submitter supplied) Latent tuberculosis infection (LTBI) relies on a homeostasis of macrophages and Mycobacterium tuberculosis (Mtb). The small heat shock protein, Mtb Hsp16.3 (also known as latency-associated antigen), plays an important role in Mtb persistence within macrophages. However, the mechanism of LTBI remains elusive. The aim of this study was to delineate LTBI-related miRNA expression in U937 macrophages expressing Mtb Hsp16.3 protein. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18244
2 Samples

Download data: TXT

Series

Accession:: GSE54630

ID:: 200054630

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001311744.

Profiling of the host small non-coding RNAome in Mycobacterium tuberculosis infection

(Submitter supplied) We report a study about differentially expressed small non-coding RNAs in the blood of humans harboring a latent (LTBI) or active tuberculosis (TB) infection in comparison with exposed controls (ExC) and treated LTBI (LTBItt). All non-TB subjects enrolled in this study were recent close contacts (rCt) of a newly diagnosed contagious TB cases enrolled in Rio de Janeiro, Brazil. The detailed methodology is described below. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
49 Samples

Download data: TXT

Series

Accession:: GSE131174

ID:: 200131174

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Select item 2000296285.

The time-course transcriptomic responses of THP-1 human macrophage-like cells to W-Beijing Mycobacterium tuberculosis strains of different sublineages

(Submitter supplied) The W-Beijing family of Mycobacterium tuberculosis (Mtb) strains is known for its high-prevalence and -virulence, as well as for its genetic diversity, as recently reported by our laboratories and others. However, little is known about how the immune system responds to these strains. To explore this issue, here we used reverse engineering and genome-wide expression profiling of human macrophage-like THP-1 cells infected by different Mtb strains of the W-Beijing family, as well as by the reference laboratory strain H37Rv. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4258
Platform:: GPL570
40 Samples

Download data: CEL

Series

Accession:: GSE29628

ID:: 200029628

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Select item 42586.

THP-1 macrophage-like cells response to W-Beijing Mycobacterium tuberculosis strains: time course

Temporal analysis of macrophage-like THP-1 cell line infected by Mycobacterium tuberculosis (Mtb) W-Beijing strains and H37Rv. Mtb W-Beijing sublineages are highly virulent, prevalent and genetically diverse. Results provide insight into host macrophage immune response to Mtb W-Beijing strains.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 infection, 13 strain, 4 time sets

Platform:: GPL570
Series:: GSE29628
40 Samples

Download data: CEL

DataSet

Accession:: GDS4258

ID:: 4258

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001653277.

Real-time quantitative PCR analysis of PMA differentiated THP-1 infected with H37Rv or M. marinum, or heat killed H37Ra (HKMT)

(Submitter supplied) THP-1 cells were differentiated into macrophages with 0,1 µM PMA overnight then infected for 2 days with either H37Rv, M. marinum or heat killed H37Ra. Then RNA was collected in order to quantify the inflammatory response transcription as compared with the relative uninfected controls.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL29639
22 Samples

Download data: TXT

Series

Accession:: GSE165327

ID:: 200165327

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Select item 2001642878.

RNA sequencing-based analysis of transcriptional reprogramming of primary human monocyte-derived macrophages infected with Mycobacterium tuberculosis

(Submitter supplied) Primary human monocytes were isolated from four healthy human blood donors. Monocytes were isolated from PBMC buffy coats using plastic adherence for 4 hours. Monocytes were allowed to differentiate into macrophages over a period of 1 week. Macrophages from each of the 4 donors were split into two groups - uninfected and infected with Mycobacterium tuberculosis (Mtb). Cells in the infection group were infected with Mtb for 48 hours at a multiplicity of infection (MOI) of 10. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: CSV

Series

Accession:: GSE164287

ID:: 200164287

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Select item 2001510509.

Differential production of small RNAs in Mycobacterium tuberculosis infected primary human monocyte-derived macrophages

(Submitter supplied) Primary human monocytes were isolated from four healthy donors. Monocytes were differentiated into macrophages, infected with virulent Mycobacterium tuberculosis (Mtb), strain H37Rv, for 24 or 48 hours, at a multiplicity of infection of 5 or 10. Following infection, infected cells and time-matched uninfected controls were harvested, total RNA including small RNAs was isolated and used for next-generation small RNA sequencing. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: CSV

Series

Accession:: GSE151050

ID:: 200151050

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Select item 20007973310.

Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13712
27 Samples

Download data: CEL

Series

Accession:: GSE79733

ID:: 200079733

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Select item 20007973211.

Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages [validation]

(Submitter supplied) How the complex interaction between Mycobacterium tuberculosis (Mtb) and the host is regulated during infection is still not well understood. Using a systems biology approach, we demonstrate here that miR-155 is one of several microRNAs that regulate host gene expression over the first 48 hours of Mtb infection in macrophages. miR-155 regulates the cell survival of Mtb-infected macrophages through SHIP1/AKT signaling. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13712
12 Samples

Download data: CEL

Series

Accession:: GSE79732

ID:: 200079732

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Select item 20007973112.

Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages [timecourse]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13712
15 Samples

Download data: CEL

Series

Accession:: GSE79731

ID:: 200079731

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009400713.

TaqMan Human miRNA array profile of Mycobacterium tuberculosis H37Rv infected THP-1 differentiated macrophages cells.

(Submitter supplied) Differentially regulated miRNA candidates in H37Rv infected THP-1 cells were analysed with respect to uninfected THP-1 reference samples. THP-1 cells are monocytes differentiated to macrophages after treatment with PMA for 48 hrs. Total RNA was isolated from infected THP-1 cells after 24 hrs of infection, cDNA was synthesized for TLDA real time PCR reaction using TaqMan MicroRNA Reverse Transcription kit and Megaplex Human Pool A and Pool B stem loop RT primers (version 3.0) as per manufacturer’s protocol. more...

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR; Non-coding RNA profiling by array

Platform:: GPL22977
2 Samples

Download data: TXT

Series

Accession:: GSE94007

ID:: 200094007

Select item 20006442714.

Time-dependent global gene expression profile of RAW264.7 cells infected with Mycobacterium tuberculosis H37Rv (Mtb)

(Submitter supplied) Transcriptional profiling of RAW264.7 cells infected with M. tuberculosis H37Rv at an MOI of 10 performed 4 and 24 hours post-infection.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13381
4 Samples

Download data: TXT

Series

Accession:: GSE64427

ID:: 200064427

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Select item 20006252515.

Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis

(Submitter supplied) Tuberculosis (TB) is a serious infectious disease, but current methods of detection require improvement in sensitivity, efficiency or specificity. We conducted a microarray experiment, comparing the gene expression profiles in peripheral blood mononuclear cells among individuals with active TB, latent infection, and healthy conditions in a Taiwanese population. These differentially expressed genes may be potential biomarkers that can differentiate between active TB and latent infection.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16951
42 Samples

Download data: GPR

Series

Accession:: GSE62525

ID:: 200062525

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001119916.

Identification of Tuberculosis Susceptibility Genes with Human Macrophage Gene Expression Profiles

(Submitter supplied) Although host genetics influences susceptibility to tuberculosis, few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of tuberculosis infection would have distinct gene expression profiles, and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb- stimulated macrophages in 12 subjects with 3 clinical phenotypes: latent, pulmonary and meningeal tuberculosis (n=4 per group). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3540
Platform:: GPL570
24 Samples

Download data: CEL

Series

Accession:: GSE11199

ID:: 200011199

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 354017.

Macrophages from tuberculosis infected subjects response to M. tuberculosis cell lysate ex vivo

Ex vivo analysis of macrophages from individuals with a history of latent, pulmonary and meningeal tuberculosis (TB) following treatment with cell lysates of Mycobacterium tuberculosis H37Rv. Results provide insight into the molecular basis of susceptibility to TB.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 3 disease state sets

Platform:: GPL570
Series:: GSE11199
24 Samples

Download data: CEL

DataSet

Accession:: GDS3540

ID:: 3540

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20004994718.

Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits

(Submitter supplied) In our rabbit model of pulmonary tuberculosis, infection with Mtb HN878, a hyper-virulent W-Beijing strain, results in progressive cavitary disease. However, infection of rabbit lungs with Mtb CDC1551, a hyper-immunogenic strain is effectively controlled overtime, establishing latent Mtb infection. Using these two Mtb strains, we tested the hypothesis that the initial host response in the lungs within hours of infection determines later outcome. more...

Organism:: Oryctolagus cuniculus

Type:: Expression profiling by array

Platform:: GPL13288
8 Samples

Download data: TXT

Series

Accession:: GSE49947

ID:: 200049947

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Select item 20002710019.

Integrated miRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection

(Submitter supplied) The host response to mycobacterial infections was studied after infection of macrophages derived from primary human monocytes. mRNA and miRNA expression studies were performed to identify key regulators of immune defence and their targets.

Organism:: Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; human gammaherpesvirus 4; Betapolyomavirus macacae

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL7722 GPL10128
12 Samples

Download data: GPR

Series

Accession:: GSE27100

ID:: 200027100

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Select item 20006742720.

Mycobacterial infection induces a specific human innate immune response

(Submitter supplied) The innate immune system provides the first response to pathogen infection and orchestrates the activation of the adaptive immune system. Though a large component of the innate immune response is common to all infections, pathogen-specific innate immune responses have been documented as well. The innate immune response is thought to be especially critical for fighting infection with Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
156 Samples

Download data: TXT

Series

Accession:: GSE67427

ID:: 200067427

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

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