Similar studies for GEO DataSets (Select 200066106) - GEO DataSets

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Items: 20

Select item 2000661061.

Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast

(Submitter supplied) Specialized chromatin containing CENP-A nucleosomes instead of H3 nucleosomes is found at all centromeres. However, the mechanisms that specify the locations at which CENP-A chromatin is assembled remain elusive in organisms with regional, epigenetically regulated centromeres. It is known that normal centromeric DNA is transcribed in several systems including the fission yeast, Schizosaccharomyces pombe. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL7715
24 Samples

Download data: BAR, CEL

Series

Accession:: GSE66106

ID:: 200066106

PubMed Full text in PMC Similar studies

Select item 2000995892.

The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3

(Submitter supplied) Centromere is the chromosomal locus at which kinetochore is assembled to direct chromosome segregation. Histone H3 variant CENP-A epigenetically marks active centromeres; however, the mechanism by which CENP-A propagates at the centromere, replacing histone H3, remains poorly understood. Using fission yeast, we find that CENP-ACnp1 chromatin assembly at the centromere requires the Ino80 ATP-dependent chromatin remodeling complex which removes histone H3-containing nucleosomes from associated chromatin. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17225
98 Samples

Download data

Series

Accession:: GSE99589

ID:: 200099589

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001199223.

Centromeric DNA destabilizes H3 nucleosomes to promote CENP-A deposition during the cell cycle (part 3)

(Submitter supplied) Centromeres are the regions of eukaryotic chromosomes where kinetochores are assembled and direct the correct segregation of chromosomes. Active centromeres are defined by presence of nucleosomes containing CENP-A, a histone H3 variant, which alone is sufficient to direct kinetochore assembly. Once assembled at a location CENP-A chromatin and the kinetochore is maintained at that location though a positive feedback loop where kinetochore proteins recruited by CENP-A promote deposition of new CENP-A following replication. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL23689 GPL25575
15 Samples

Download data: BW

Series

Accession:: GSE119922

ID:: 200119922

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001064944.

Centromeric DNA destabilizes H3 nucleosomes to promote CENP-A deposition during the cell cycle

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17225 GPL25575 GPL23689
59 Samples

Download data: BW

Series

Accession:: GSE106494

ID:: 200106494

PubMed Full text in PMC Similar studies

Select item 2001064925.

Centromeric DNA destabilizes H3 nucleosomes to promote CENP-A deposition during the cell cycle (part 2)

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17225
40 Samples

Download data: BW

Series

Accession:: GSE106492

ID:: 200106492

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001064916.

Centromeric DNA destabilizes H3 nucleosomes to promote CENP-A deposition during the cell cycle (part 1)

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17225
4 Samples

Download data: BW

Series

Accession:: GSE106491

ID:: 200106491

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001415247.

Analysis of Hap2-GFP and Arp5-3HA ChIP-Seq from fission yeast

(Submitter supplied) High coincidence was observed for Hap2 and Arp5 peaks

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25575
6 Samples

Download data: BED, BW

Series

Accession:: GSE141524

ID:: 200141524

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001363058.

Hap2-Ino80 mediated transcription facilitates de novo establishment of CENP-A chromatin

(Submitter supplied) Analysis of CENP-ACnp1 ChIP-Nexus from fission yeast

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17225
2 Samples

Download data: BW

Series

Accession:: GSE136305

ID:: 200136305

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000442069.

DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast

(Submitter supplied) Centromeres are specialized chromatin regions marked by the presence of nucleosomes containing the centromere-specific histone H3 variant CENP-A, which is essential for chromosome segregation. Assembly and disassembly of nucleosomes is intimately linked to DNA topology and DNA topoisomerases have previously been implicated in the dynamics of canonical H3 nucleosomes. Here we show that Schizosaccharomyces pombe Top3 and its partner Rqh1 are involved in controlling the levels of CENP-ACnp1 at centromeres. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by genome tiling array; Genome binding/occupancy profiling by genome tiling array

Platform:: GPL7715
5 Samples

Download data: BAR, CEL, TXT

Series

Accession:: GSE44206

ID:: 200044206

PubMed Full text in PMC Similar studies

Select item 20011245410.

Fission yeasts CENPA and H3K9me Chip-seq

Organism:: Schizosaccharomyces pombe; Schizosaccharomyces octosporus; Schizosaccharomyces japonicus; Schizosaccharomyces cryophilus

Type:: Genome binding/occupancy profiling by high throughput sequencing

6 related Platforms
26 Samples

Download data: BW

Series

Accession:: GSE112454

ID:: 200112454

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006429411.

A high-resolution map of inner kinetochore proteins in fission yeast regional centromeres

(Submitter supplied) We use high-resolution chemical cleavage mapping and both native and cross-linked chromatin immunoprecipitation with paired-end sequencing to elucidate the profile of nuceleosomes containing the centromere-specific variant of H3 (cenH3), known as CENP-A or Cnp1 in fission yeast. We find that in the central domain of fission yeast centromeres H3 nucleosomes are nearly absent and CENP-A nucleosomes are more widely spaced that nucleosomes elsewere. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17225
41 Samples

Download data: BED, WIG

Series

Accession:: GSE64294

ID:: 200064294

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004642712.

Telomeric repeats facilitate CENP-A incorporation via telomere binding proteins

(Submitter supplied) The histone H3 variant, CENP-ACnp1, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined. To explore the tolerances and constraints on CENP-ACnp1 deposition we investigated whether certain locations are favoured when additional CENP-ACnp1 is present in fission yeast cells. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL7715
2 Samples

Download data: BAR, CEL, TXT

Series

Accession:: GSE46427

ID:: 200046427

PubMed Full text in PMC Similar studies

Select item 20000756013.

Sim3, a NASP (N1/N2) related protein, escorts CENP-A for deposition at fission yeast centromeres

(Submitter supplied) A defining feature of centromeres is the presence of the histone H3 variant CENP-ACnp1. It is not known how CENP-ACnp1 is specifically delivered to, and assembled into centromeric chromatin. Through a screen for factors involved in kinetochore integrity in fission yeast we identified Sim3. Sim3 is homologous to known histone binding proteins NASPHuman and N1/N2Xenopus and aligns with Hif1S.cerevisiae to define the SHNi-TPR family. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by array

Platforms:: GPL5099 GPL4550
4 Samples

Download data: TXT

Series

Accession:: GSE7560

ID:: 200007560

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003552714.

Mediator promotes CENP-A incorporation at fission yeast centromeres

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL7715 GPL13988
5 Samples

Download data: BAR, BED, CEL, WIG

Series

Accession:: GSE35527

ID:: 200035527

PubMed Full text in PMC Similar studies

Select item 20003552415.

Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq]

(Submitter supplied) At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A/Cnp1, which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (Pol II) directs heterochromatin formation via the RNAi machinery, but also through RNAiindependent RNA processing factors. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13988
3 Samples

Download data: BED, WIG

Series

Accession:: GSE35524

ID:: 200035524

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003231016.

Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe

(Submitter supplied) At Schizosaccharomyces pombe centromeres, non-coding RNAs are transcribed by RNA polymerase II and processed by the RNAi machinery to direct heterochromatin formation. Mediator is a regulator of RNA polymerase II transcription and we here demonstrated that it also controls the levels of centromeric transcripts. Loss of the Mediator subunit Med20 increases transcription of non-coding RNAs and disrupts the centromeric heterochromatin structure. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by genome tiling array

Platform:: GPL7715
2 Samples

Download data: BAR, CEL

Series

Accession:: GSE32310

ID:: 200032310

PubMed Full text in PMC Similar studies

Select item 20006335017.

The N-terminal Tail of CENP-A Confers Epigenetic Stability to Centromeres via the CENP-T Branch of the CCAN in Fission Yeast

(Submitter supplied) We employ the well-studied fission yeast centromere to investigate the function of the CENP-A (Cnp1) N-tail. We show that alteration of the N-tail did not affect Cnp1 loading at centromeres, outer kinetochore formation, or spindle checkpoint signaling, but nevertheless elevated chromosome loss. N-Tail mutants exhibited synthetic lethality with an altered centromeric DNA sequence, with rare survivors harboring chromosomal fusions in which the altered centromere was epigenetically inactivated. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9854
4 Samples

Download data: BW

Series

Accession:: GSE63350

ID:: 200063350

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010623218.

Genome-wide mapping of Cnp1 of wild-type and various deletion strains in fission yeast.

(Submitter supplied) ccp1Δ, gar2Δ showed wild-type level of genome-wide Cnp1 distribution.

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL22668
6 Samples

Download data: BEDGRAPH

Series

Accession:: GSE106232

ID:: 200106232

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009504719.

Genome-wide mapping of fission yeast

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL22668
21 Samples

Download data: BEDGRAPH

Series

Accession:: GSE95047

ID:: 200095047

PubMed Full text in PMC Similar studies

Select item 20009504620.

Genome-wide mapping of Ccp1 association sites in fission yeast

(Submitter supplied) In our genetic screen, we found that Ccp1 is an epigenetic stability modulator in centromeres and heterochromatin in S. pombe. In interphase cells,Ccp1-GFP enriched at centromeres. To determine the association sites of Ccp1 with the centromeres and to characterize the global distribution pattern of Ccp1 throughout the genome, ChIP-seq were performed for Myc-tagged Ccp1 (C-terminal fusion protein). The result revealed that Ccp1 associates with the central core regions (cnt and imr) within every single centromere.

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL22668
4 Samples

Download data: BEDGRAPH

Series

Accession:: GSE95046

ID:: 200095046

PubMed Full text in PMC Similar studies SRA Run Selector

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