Similar studies for GEO DataSets (Select 200070962) - GEO DataSets

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Items: 20

Select item 2000709621.

Analysis of Junctional zone in murine placenta upon loss of Tfap2c

(Submitter supplied) Tfap2c is deleted in Tpbpa positive precursor cells forming the junctional zone of murine placenta. Deregulation in gene expression is analysed compared to the junctional zone in control placenta.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
2 Samples

Download data: TXT

Series

Accession:: GSE70962

ID:: 200070962

Select item 2000516442.

Microarray analysis of gene expression profiles in Map2k1+/-Map2k2+/- and Map2k1flox/-Map2k2+/-Tg+/Sox2Cre placentas

(Submitter supplied) The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and Map2k2, encoding dual-specificity kinases responsible for ERK/MAP kinase activation. Loss of Map2k1 function in mouse causes embryonic lethality due to placental defects, while Map2k2 mutant mice survive with a normal lifespan. The Map2k1 mutation interferes with the growth of the labyrinthine region of the placenta and its vascularization. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
12 Samples

Download data: TXT

Series

Accession:: GSE51644

ID:: 200051644

Select item 2000070963.

cDNA microarray data of bovine placenta

(Submitter supplied) Gene expression patterns of bovine placenta from initial to late stage of pregnancy were investigated by using the our custom designed utero-placental cDNA microarray. Keywords: Time course

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL1221
18 Samples

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Series

Accession:: GSE7096

ID:: 200007096

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000459414.

Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice

(Submitter supplied) Maintenance and maturation of primordial germ cells is controlled by complex genetic and epigenetic cascades, and disturbances in this network lead to either infertility or malignant aberration. Transcription factor Tcfap2c / TFAP2C has been described to be essential for primordial germ cell maintenance and to be upregulated in several human germ cell cancers. Using global gene expression profiling, we identified genes deregulated upon loss of Tcfap2c in primordial germ cell-like cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5382
Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE45941

ID:: 200045941

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Select item 53825.

Transcription factor Tcfap2c deficiency effect on primordial germ cells

Analysis of embryonic stem cells (ESCs) depleted for transcription factor Tcfap2c and PGC-like cells (PGCLCs) derived from the Tcfap2c-deficient ESCs. TFAP2C is a member of the activator protein-2 (AP-2) family. Results provide insight into the role of TFAP2C in germ cell fate.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 cell type, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE45941
8 Samples

Download data: CEL

DataSet

Accession:: GDS5382

ID:: 5382

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2002058316.

AKT1-FOXO4 Axis Regulates Hemochorial Placentation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25947
16 Samples

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Series

Accession:: GSE205831

ID:: 200205831

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Select item 2002058287.

AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]

(Submitter supplied) AKT1 is a serine/threonine kinase implicated in fetal, placental, and postnatal growth. In this study, we investigated roles for AKT1 in placental development using a genome-edited/loss-of-function rat model. Both heterozygous and homozygous Akt1 mutant rats were viable and fertile. Disruption of AKT1 resulted in placental, fetal, and postnatal growth restriction. Akt1 null placentas showed deficits in both junctional zone and labyrinth zone size and their ability to adapt to a physiological stressor. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25947
6 Samples

Download data: XLSX

Series

Accession:: GSE205828

ID:: 200205828

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Select item 2000126288.

Cardiac samples from OTT1 null/null and OTT1 null/wt embryonic mice

(Submitter supplied) The infant leukemia-associated gene, Ott1(Rbm15), has broad regulatory effects within the murine hematopoiesis. However, germline Ott1 deletion results in fetal demise prior to E10.5, indicating additional developmental requirements for Ott1. The spen gene family, to which Ott1 belongs, has a transcriptional activation/repression domain and RNA recognition motifs, and in Drosophila has a significant role in the development of the head and thorax. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE12628

ID:: 200012628

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Select item 2000743189.

The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources

(Submitter supplied) Recent work suggests that imprinted genes may regulate the signalling function of the placenta by modulating the size of the endocrine compartment. Our work provides in vivo evidence that this hypothesis is well founded. Affymetrix Mouse Microarray analysis of E16.5 placneta was used to demonstrate gene expression changes in the mutant placenta.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
11 Samples

Download data: CEL

Series

Accession:: GSE74318

ID:: 200074318

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Select item 20010502210.

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency

(Submitter supplied) To elucidate the molecular basis of BMP4-induced differentiation of human pluripotent stem cells (PSCs) toward progeny with trophectoderm characteristics, we produced transcriptome, epigenome H3K4me3, H3K27me3, and CpG methylation maps of trophoblast progenitors, purified using the surface marker APA. We combined them with the temporally resolved transcriptome of the preprogenitor phase and of single APA+ cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18460
768 Samples

Download data: TXT

Series

Accession:: GSE105022

ID:: 200105022

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010496911.

Time series total RNA sequencing of a differentiation of human embryonic stem cells towards trophoblast lineage

(Submitter supplied) Human embryonic stem cells (hESC) can be differentiated towards progeny resembling trophoblast upon exposure to BMP4. Here we analysed transcriptional changes in cells undergoing commitment to trophoblast at 6 time points using total RNA sequencing and identified early and late regulators of trophoblast fate.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: CSV

Series

Accession:: GSE104969

ID:: 200104969

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Select item 20010481812.

Expression data from APA+ and APA- progenitors and SSEA5+ human pluripotent stem cells

(Submitter supplied) Human embryonic stem cells (hESC) can be differentiated into progenitors resembling trophoblast upon exposure to BMP4. Putative trophpblast progenitors express APA cell surface marker Using FACS sorting and microarray we analysed the gene expression of APA-positive trophoblast progenitors, APA-negative progenitors and SSEA5-positive undifferentiated hESC and identified genes that contribute to the trophoblast fate

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
9 Samples

Download data: CEL

Series

Accession:: GSE104818

ID:: 200104818

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Select item 20020853913.

Unraveling the role of human TSC-specific TFs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
29 Samples

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Series

Accession:: GSE208539

ID:: 200208539

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Select item 20020853814.

Unraveling the role of human TSC-specific TFs [RNA-Seq]

(Submitter supplied) Orchestrated actions of tissue-specific enhancers and transcription factors (TFs) govern the development of the placenta which is an essential organ to support the growth of the fetus during pregnancy. However, human trophoblast stem cells (TSCs)-specific enhancers, TFs, and the mechanisms by which TFs modulate placental development are poorly understood. Here we investigated enhancers, super-enhancers (SE), SE-associated genes in human TSC using RNA-seq and ChIP-seq to interrogate the roles of SE-TFs in human TSCs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
14 Samples

Download data: TXT, XLSX

Series

Accession:: GSE208538

ID:: 200208538

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Select item 20020836115.

Unraveling the role of human TSC-specific TFs [ChIP-Seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
15 Samples

Download data: TXT

Series

Accession:: GSE208361

ID:: 200208361

PubMed Full text in PMC Similar studies

Select item 20001548116.

Gene expression data from AP-2γ silenced MCF-7 cells

(Submitter supplied) Overexpression of the AP-2γ transcription factor in breast tumours has been identified as an independent predictor of poor outcome and failure of hormone therapy, even in ER positive, ErbB2 negative tumours; markers of a more favourable prognosis. To understand further the role of AP-2γ in breast carcinoma, we have used an RNA interference and gene expression profiling strategy using the MCF-7 cell line as a model for ER positive, ErbB2 negative tumours with AP-2γ overexpression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3722
Platform:: GPL570
15 Samples

Download data: CEL

Series

Accession:: GSE15481

ID:: 200015481

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 372217.

Activator protein-2gamma silencing effect on MCF-7 breast tumor cell line

Analysis of MCF-7 cells silenced for activator protein (AP)-2γ transcription factor using three distinct self-targeting sequences (AP-2γ siRNA1-3). AP-2γ overexpression in breast tumors is a predictor of poor outcome. Results provide further insight into the role of AP-2γ in breast carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 5 protocol sets

Platform:: GPL570
Series:: GSE15481
15 Samples

Download data: CEL

DataSet

Accession:: GDS3722

ID:: 3722

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20002827718.

Altered Gene Expression in Placentae from a Mouse Model of Diabetic Pregnancy

(Submitter supplied) AIMS/HYPOTHESIS: Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, such as metabolic syndrome and hypertension. We hypothesized that adverse outcomes from diabetic pregnancies may be linked to compromised placental function. Our goal in this study was to identify cellular and molecular abnormalities in diabetic placenta. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3989
Platform:: GPL1261
10 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE28277

ID:: 200028277

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 398919.

Diabetic pregnancy model: placenta and decidua

Analysis of placentae (including decidua) of streptozotocin-induced diabetic FVB dams at gestational day E10.5. Adverse outcomes from diabetic pregnancies may be linked to compromised placental function. Results provide insight into molecular basis of placental abnormalities in diabetic pregnancies.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL1261
Series:: GSE28277
10 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3989

ID:: 3989

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20012606920.

Usp22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta

(Submitter supplied) Usp22, a component of the SAGA complex, is over expressed in highly aggressive cancers, but the normal functions of this deubiquitinase are not well defined. We determined that loss of Usp22 in mice results in embryonic lethality due to defects in extra-embryonic placental tissues and failure to establish proper vascular interactions with the maternal circulatory system. These phenotypes arise from abnormal gene expression patterns that reflect defective kinase signaling, including TGFβ and several receptor tyrosine kinase (RTK) pathways. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
5 Samples

Download data: TXT

Series

Accession:: GSE126069

ID:: 200126069

PubMed Full text in PMC Similar studies SRA Run Selector

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